7. Adenocarcinoma
Origin: glandular tissue.
Sites: endocrine, exocrine glands, mucus
membranes, GIT, endometrium.
Gross: in solid organsirregular infiltrative
growth, in hollow organsfungating, infiltrating
or ulcerating growth.
Microscopically: irregular glands in size and
shape,lined by malignant cells and separated by
C.T. stroma.
Grading: depends on tubule formation,
number of mitoses and irregular nuclear pattern.
15. Mucoid carcinoma
Origin: from glandular epithelium.
Sites: mostly in GIT.
Grossly: appears as soft gelatinous mass.
Microscopicaly:
1-Mucoid carcinoma: mucoid differentiation in
an adenocarcinoma rupture of cells release
of large amount of extra-cellular mucin.
2-Signet cell carcinoma: cells are distended
with intracellular mucin--. Signet ring cells with
minimal extrapcellular mucin.
18. Basal cell crcinoma
((Rodent ulcer
Def: locally malignant tumor arising from the
basal cell layer of epidermis.
Sites: skin areas exposed to sun as in face.
Gossly: starts as a papule rodent ulcer
( raised everted edge,rough and necrotic floor,
indurated edge).
Histologically: invasion of the dermis by
variable sized masses formed of malignant
basaloid cells that form palisade appearance at
the periphery.