2. DISSOLUTION A process in which a solid substance solubilizes in a given solvent. i.e. mass transfer from the solid surface to the liquid phase. USP DISSOLUTION APPARATUS • Apparatus 1 - Basket (37º) • Apparatus 2 - Paddle (37º) • Apparatus 3 - Reciprocating Cylinder (37º) • Apparatus 4 – Flow-Through Cell (37º)
3. • Apparatus 5 – Paddle over Disk (32º), Transdermal Delivery System, use paddle and vessel from Apparatus 2 with a stainless steel disk assembly to hold the transdermal on the bottom of vessel. • Apparatus 6, Cylinder (32º), Transdermal Delivery System, use Apparatus 1 except replace the basket shaft with a stainless steel cylinder element. • Apparatus 7, Reciprocating Holder, for transdermal delivery systems and also a variety of dosage forms
4. APPARATUS 1: The assembly consists of the following : A covered vessel, Transparent material, A motor, A metallic drive shaft, A cylindrical basket, The water bath permits the holding of temp inside vessel at 37±0.5 ̊C The vessel is a cylindrical with hemispherical bottom with dimension and capacity of.
14. Within the time interval, withdraw a specimen from zone midway between the surface of the dissolution medium and the top of the rotating basket or blade , not less than 1cm from vessel wall.
21. During the upward and downward stroke, the reciprocating cylinder moves through a total distance of 9.9 to 10.1 cm
22. Within the time interval specified withdraw a portion of the solution under test from a zone midway between the surface of the dissolution medium and the bottom of each vessel.
23.
24. The pump forces the dissolution medium upwards through the flow-through cell.
25. The pump has a delivery range between 240 and 960 mL per hour, with standard flow rates of 4, 8, and 16 mL per minutes.
26. The cell is immersed in a water bath and the temperature is maintained at 37 + 0.5°
37. The system may be attached to the disk by a suitable adhesive.
38. Place the disk assembly flat at the bottom of the vessel with the release surface facing up and parallel to of the paddle blade and surface of the dissolution medium.
40. At each sampling time interval, withdraw a sample from a zone midway between the surface of the dissolution medium and the top of the blade, not less than 1 cm from the vessel wall.
41.
42. The dosage unit is placed on the cylinder at the beginning of each test.
49. Place the cylinder in the apparatus and immediately rotate at the rate specified
50. Within the time interval specified, withdraw a quantity of dissolution medium for analysis from a zone midway between the surface of the dissolution medium and the top of the rotating cylinder, not less than 1 cm from the vessel wall.
51.
52. A motor and drive assembly to reciprocate the system vertically