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Panel Introduction
Closing the gap between research and practice: 
Successful technology transfer strategies in combating 
resistance to medication‐assisted treatment
Addiction Health Services Research 
Conference 2011
Olivia Ryan, M.P.A.
University of Missouri – Kansas City
ATTC National Office
ryanom@umkc.edu
• About the Addiction Technology 
Transfer Center (ATTC) Network
• Setting the Context: Where are we 
with MAT?
• NIDA/SAMHSA Blending Initiative 
Overview: A focus on medication‐
assisted treatment
• MAT in Special Populations
Panel Agenda
3
The ATTC Network 2007‐2012
The ATTC Network’s Vision
Southern
Coast
All professionals who
address the needs of
individuals with, or
who are at risk of
having, substance
use disorders will
utilize effective,
culturally responsive
practices that lead to
improved healthcare
and long-term health
and wellness.
SAMHSA’s Plan for 2011-14
SAMHSA’s 8 Strategic Initiatives
1) Prevention of Substance Abuse and Mental Illness
2) Trauma and Justice
3) Military Families
4) Recovery Support
5) Health Reform
6) Health Information Technology
7) Data, Outcomes, and Quality
8) Public Awareness and Support
Our Role in SAMHSA’s Plan
• The ATTC Network conducts
numerous efforts across
SAMHSA’s eight Strategic
Initiatives
• The ATTC Network is a stable
infrastructure to address the
objectives outlined by SAMHSA
in the “Leading Change” plan
ATTC Activities related to each initiative
September 2009-2010
*Health Information Technology
*
What is Technology Transfer?
Southern
Coast
What is Technology Transfer?
Copyright 2010 ATTC Network
• About the Addiction Technology 
Transfer Center (ATTC) Network
• Setting the Context: Where are we 
with MAT?
• NIDA/SAMHSA Blending Initiative 
Overview: A focus on medication‐
assisted treatment
• MAT in Special Populations
Panel Agenda
Setting the Context: Where are we with MAT?
Addiction Health Services Research Conference 2011
Traci Rieckmann, Ph.D.
Oregon Health & Sciences University
Northwest Frontier ATTC
rieckman@ohsu.edu
Setting the Context – Agenda
 Background
 MAT Implementation
 ATTC MAT Resources
 Definition: MAT is the use of medication, combined with 
counseling and behavioral therapies, to provide a whole 
patient approach to the treatment of substance use disorders. 
(http://www.dpt.samhsa.gov )
 Use of pharmacotherapy for drug dependence and 
detoxification is expanding 
 Research continues to confirm that the use of MAT provides 
better outcomes, and reductions in drug use, mortality rates, 
and criminal activity (Rieckmann et al., 2010; Woody et al., 
2008; Saxon & McCarty, 2005; Greenfeld & Fountain, 2000).
BACKGROUND
MAT Effectiveness
 Published by SASMHA as Treatment Improvement Protocol 
(TIP) 43, MAT is a widely recognized evidence based practice
 Research indicates that MAT is effective for opioid dependent 
patients seeking treatment along with counseling (Marchand
et al., 2011).
 MAT is cost effective & provides more health benefits than 
providing treatment without medication (M. Connock et al., 
2007)
BACKGROUND
 Agonist therapy or MAT, has been hailed as the most effective 
treatment, especially when combined with psychotherapy 
(Barnett et al., 2001).
 MAT Goals:
• Reduce symptoms and signs of withdrawal
• Reduce or eliminate craving
• Block effects of alcohol or illicit opioids
• Restore normal physiology
• Promote psychosocial rehabilitation and non‐drug lifestyle
 Research to date confirms lower risk of abuse, overdose, and 
toxicity and diminished withdrawal symptoms when using 
medication assisted treatment (Burns et al., 2009).
BACKGROUND
Use & Effectiveness
Approved Medications
Medications for Alcohol Dependence
 Naltrexone (ReVia®, Vivitrol®, Depade®)
 Disulfiran (Antabuse®)
 Acamprosate Calcium (Campral®) 
Medications for Opioid Dependence
 Methadone
 Buprenorphine (Suboxone® and Subutex®)
 Naltrexone
BACKGROUND
 Clinical trials have demonstrated efficacy of MATs for opioid 
dependent patients
• Clinical trial of Buprenorphine (Bickel et al., 1988)
• CTN 0003: Suboxone taper: a comparison of two schedules 
(Amass et al., 2004; Ling et al., 2010).
 Physician Clinical Support System (Fiellin et al., 2008).
• PCSS‐B
BACKGROUND
MAT Trials
Setting the Context – Agenda
 Background
 MAT Implementation
 ATTC MAT Resources
MAT IMPLEMENTATION
Comprehensive Tx Plan
Psychosocial Treatments
Medications
Reduce symptoms and signs of withdrawal
Reduce or eliminate craving
Block effects of alcohol or illicit opioids
Restore normal physiology
Promote psychosocial rehabilitation and non‐drug 
lifestyle
MAT IMPLEMENTATION
ATTC Network Definition of Implementation
Incorporating an innovation into routine practice. Implementation 
ideally includes a range of strategies designed to address individual, 
organizational, and systemic characteristics (e.g., skills training, 
administrative buy‐in, and policy changes).
Barriers to Implementation
 Gap between research and practice
• Adoption of medication to treat SUDs remains slow 
despite evidence of effectiveness
• There is a critical need to merge the gap between 
research and practice with MAT
 Organizational factors
• Two‐thirds of organizations' efforts to implement 
change fail (Damschroder et al., 2009).
• Implementation requires an active change process 
aimed to achieve individual and organizational level 
use of the intervention as designed (Damshroder at 
al., 2009).
MAT IMPLEMENTATION ‐ BARRIERS
Barriers to Implementation
 Workforce resistance
• Less than 45% of US substance use disorder 
treatment programs are found to prescribe any 
single SUD medication (Roman et al., 2011).
MAT IMPLEMENTATION ‐ BARRIERS
Gap Between Research and Practice
 According to SAMHSA’s National Survey of Substance Abuse 
Treatment Services, only 22.3% of patients seeking treatment 
for a SUD were receiving medication assisted treatment‐
Methadone and Buprenorphine (Substance Abuse and Mental 
Health Services Administration, N‐SSATS Report, 2008).
 Similarly – The National Treatment Center Studies from UGA 
found that 14.3% of programs reported using 
Buprenorphine,10.7% use Methadone, 15.2% use Naltrexone, 
and 16.5% use Disulfiram, from a 2007 study (Knudsen et al., 
2010).
BARRIERSMAT IMPLEMENTATION ‐ BARRIERS
Organizational Factors as Barriers
 Agencies with national accreditation  
(Ducharme et al., 2008; Knudsen et al., 2010).
 Agencies that adhere to a 12‐step model
 Focus on individual, not organizational
‐ Much of the research on implementation of evidence‐based 
SUD interventions emphasizes individual counselor training, 
with less attention on the influence of organizational factors 
(Damschroder et al., 2011).
MAT IMPLEMENTATION ‐ BARRIERS
Overcoming Organizational Barriers
 Characteristics of the medication and societal 
attitudes influence the adoption of medication 
assisted treatment (Knudsen et al., 2007; Mark et al., 
2009; Ducharme et al., 2009; Rieckmann et al., 2011).
 State regulations may create or remove barriers to 
the adoption of MATs by community‐based 
treatment provider organizations (Ducharme et al., 
2008).
 Persons endorsing a 12‐step model perceived less 
interest in addiction medication (McGovern et al., 
2004).
MAT IMPLEMENTATION ‐ BARRIERS
Workforce Barriers
 Environmental pressures including market and 
regulations, treatment philosophy, resource 
constraints, service objectives, and patient mix 
influence MAT adoption (Wallack et al., 2010; 
Scott et al., 1993).
 Lack of knowledge from physicians about 
medication assisted treatment (Mark et al., 
2003).
 Complexity of treatment, costs, regulatory limits
 Differing physician beliefs: not enough evidence
 Need for physician training
MAT IMPLEMENTATION ‐ BARRIERS
Overcoming Workforce Barriers
 Influence from society and other providers
 Specific training leads to greater acceptability
 While physician knowledge of effectiveness and 
an organization’s positive attitude toward 
medications are important, physicians are 
dependent on structural and procedural supports 
in their office settings to allow for MATs (Wallack
et al., 2010).
MAT IMPLEMENTATION ‐ BARRIERS
Achieving MAT Implementation
 Where to start: Listening and education
• Do staff understand the need or gap in 
services?
• Do staff understand the clinical 
implications of the change on their work?
• Will clients be different from the ones we 
treat now?
• Does staff have the requisite knowledge, 
tools, and equipment to be successful?
MAT IMPLEMENTATION ‐ SUCCESS
What is Needed for Successful MAT Implementation
 Research indicates that training improves staff 
attitudes and beliefs (Johnson et al., 2005; 
Knudsen et al., 2005; Rieckmann et al., 2011).
 Research also suggests that experience with 
medications (for counselors) leads to more 
positive perspectives (Thomas et al., 2003; 
Knudsen et al., 2005).
 Research network participation helps promote 
positive attitudes toward EBPs (Campbell et al., 
2003; Levant et al., 2008). 
MAT IMPLEMENTATION ‐ SUCCESS
Setting the Context – Agenda
 Background
 MAT Implementation
 ATTC MAT Resources
ATTC Strategies to Accelerate the Use of MAT
ATTC NETWORK RESOURCES
Examples of Product Development Strategies
• Curricula
• Marketing/Outreach Materials
Examples of Educational Strategies
• Online Courses, Regional Presentations & Trainings
• Learning Collaboratives
Examples of Organizational Change Strategies
• Process Improvement 
• Coaching
Examples of Systems Transformation Efforts
• Collaborations with state officials to address varying state requirements, 
regulations and funding
Conclusion
The uptake of new treatment protocols cannot always be 
guaranteed based on evidence proving the effectiveness of 
those protocols. 
Healthcare fields can often be reluctant to approach new 
treatment methods resulting in a need for outreach efforts to 
ensure that the treatment field understands the importance of 
applying new methods to practice. 
• About the Addiction Technology 
Transfer Center (ATTC) Network
• Setting the Context: Where are we 
with MAT?
• NIDA/SAMHSA Blending Initiative 
Overview: A focus on medication‐
assisted treatment
• MAT in Special Populations
Panel Agenda
NIDA/SAMHSA 
Blending Initiative 
Overview: A Focus on Medication‐
Assisted Treatment
Addiction Health Services Research Conference 2011
Thomas E. Freese, Ph.D.
University of California – Los Angeles
Pacific Southwest ATTC
tfreese@mednet.ucla.edu
Beth Rutkowski, M.P.H.
University of California – Los Angeles
Pacific Southwest ATTC
brutkowski@mednet.ucla.edu
NIDA/SAMHSA 
Blending Initiative
According to Webster’s Dictionary 
definition
To Blend means: 
a. combine into an integrated whole; 
b. produce a harmonious effect 
http://www.merriam‐webster.com/dictionary/blend
What is the Blending Initiative?
• GOAL:  To move important scientific findings into 
mainstream addiction treatment 
• Developed in 2001, NIDA and SAMHSA’s Center 
for Substance Abuse Treatment came together to 
work on a common vision:
– Improve substance use disorder treatment and 
accelerate the dissemination of research‐based 
findings into community‐based practice. 
The NIDA/SAMHSA Blending 
Initiative encompasses three 
components:
• Regional Blending Conferences
• State Agency Partnerships
• Blending Teams
Regional Blending Conferences
• Enhance bi‐directional communication 
among:
• researchers, 
• practitioners, 
• and policy‐makers
• Share innovative scientific findings about 
drug abuse and addiction
• Convene in different regions of the country
State Agency Partnerships
• NIDA and SAMHSA work closely with federal 
and state policy‐makers to help identify 
strategies to accelerate the adoption of 
science‐based practices.
Blending Teams
• Use NIDA research findings to design user‐
friendly science‐based tools for use in treatment 
settings soon after research results are published. 
• Teams include members from: 
– SAMHSA‐CSAT Addiction Technology Transfer Center 
(ATTC) Network, 
– NIDA researchers, and 
– Community treatment providers participating in the 
NIDA Drug Abuse Treatment Clinical Trials Network 
(CTN).
Blending Process
Selected CTN protocols
or other NIDA
Research
Hand-Off Meeting
Create the charge for Blending Team
Blending Team
Develop dissemination strategies and products
Current Blending Initiative 
Packages
Blending Initiative Packages
Available in Spanish
BUPRENORPHINE/NALOXONE
A Focus on Medication‐Assisted 
Treatment
Buprenorphine and Buprenorphine/Naloxone 
Help Patients Quit Opiate Abuse Goal: to disseminate 
information and 
enhance awareness 
among multi‐
disciplinary addiction 
professionals about 
buprenorphine 
treatment
http://www.nida.nih.gov/NIDA_notes/NNvol19N3/Successful.html
Buprenorphine Treatment: 
A Training for Multidisciplinary 
Addiction Professionals
Products in Package: 
– 6‐hour classroom training including a training 
manual, PowerPoint slides, and the short movie, 
“Put Your Smack Down! A Video About 
Buprenorphine”
– Annotated bibliography and research articles
Buprenorphine Treatment: 
A Training for Multidisciplinary 
Addiction Professionals
Goal: to instruct treatment providers about 
the 13‐day buprenorphine intervention.
Short‐Term Opioid Withdrawal 
Using Buprenorphine
Product in Package:
– 4‐hour classroom 
training program 
including 
PowerPoint slides 
and a CD
Buprenorphine/Naloxone
Buprenorphine
Results: Present and Opioid 
Negative 0001 (Inpatient)
0
10
20
30
40
50
60
70
80
90
Day 3-4 Day 7-8 Day 10-11 Day 13-14
Clonidine Bup/Nx
% of Individuals present at end of taper
% of opioid free urines
0
10
20
30
40
50
60
70
80
90
Day 3-4 Day 7-8 Day 10-11 Day 13-14
Clonidine Bup/Nx
% of Individuals present at end of taper
% of opioid free urines
Results: Present and Opioid 
Negative 0002 (Outpatient)
Goal: to present the results of a 
buprenorphine trial conducted with young 
adults.
Buprenorphine Treatment for Young 
Adults: Findings and Strategies from a 
NIDA Clinical Trials Network Study
Product in Package: 
3‐hour classroom 
training program 
including PowerPoint 
slides and a CD
Results: Opioid Positive 
Urine Tests
OUTCOMES
Buprenorphine‐Related Blending 
Initiative Products
The ATTC Network has:
• Completed 764 Blending Product Trainings from 
January 2005‐September 2011 (with a total of 
15,958 people)
–134 Buprenorphine Treatment (3,317 people)
–18 Short Term Opioid Withdrawal Using 
Buprenorphine (801 people)
–22 Buprenorphine for Young Adults (318 
people)
The ATTC Network has:
• Printed and distributed 567,000 brochures 
introducing each of the Blending Initiatives 
materials to the field
• Recruited and prepared trainers in every 
ATTC Region to teach the Blending Initiative 
materials
• Developed and distributed ancillary products 
to enhance the reach of the official NIDA 
products, such as curriculum infusion 
packages for addiction studies educators at 
colleges and universities.
The ATTC Network has:
• Presented information on the Blending 
Initiative at State, Regional, and National 
conferences to:
–Increase awareness about the training 
materials
–Identify new opportunities to train 
using the blending products
Products Currently 
Under Development 
1. POATS (Prescription Opioid Addiction 
Treatment Study)**
2. Onsite HIV Rapid Testing Blending 
Initiative 
Product 
Dissemination
Download the Products for FREE! Find upcoming trainings offered 
through SAMHSA’s ATTC Network!
Go to http://www.attcnetwork.org/blendinginitiative
• About the Addiction Technology 
Transfer Center (ATTC) Network
• Setting the Context: Where are we 
with MAT?
• NIDA/SAMHSA Blending Initiative 
Overview: A focus on medication‐
assisted treatment
• MAT in Special Populations
Panel Agenda
MAT in Special Populations
Addiction Health Services Research Conference 2011
Shawna Malvini Redden, MA
Arizona State University
Pacific Southwest ATTC
shawna.malvini@asu.edu
Laurie Krom, MS
University of Missouri‐Kansas City
ATTC National Office
kroml@umkc.edu 
Agenda
• Overview of the Project
• Focus Group Findings
• Products Developed
• Next Steps
Overview of the Project
Purpose of the Project
SAMHSA grant (TI‐10‐014) to increase awareness, provide 
education, and promote access to medication‐assisted treatment 
(MAT) in four specific racial and ethnic minority populations: 
African Americans
Asian/Pacific 
Islanders
Hispanic/Latinos
Native Americans/
American Indians
Overview of the Project
Purpose of the Project
Goals of the Grant: 
1. Collect data and resources to inform the development of 
products
2. Develop outreach materials for each of the special 
populations
3. Create training programs for MAT providers designed to 
enhance professionals’ knowledge and skills related to 
reaching and educating the special populations about MAT
4. Plan for additional trainings and dissemination of materials
Overview of the Project
Structure Utilized to Achieve Goals
Agenda
• Overview of the Project
• Focus Group Findings
• Products Developed
• Next Steps
Focus Group Goals
• To understand the perceived benefits and barriers of MAT
• To identify attitudes, values and social norms surrounding 
substance use
• To learn how experiences and perspectives with MAT differ 
among various cultural groups
• To prepare the substance abuse treatment workforce to 
engage minority populations in MAT
Collaborators
• “Procedural Core” led by the Pacific Southwest ATTC with 
Arizona State University researchers
Other ATTC Regional Centers in the “Procedural Core”
• Northwest Frontier ATTC at OHSU
• Prairielands ATTC at U of Iowa
• Central East ATTC at Danya Institute
• Caribbean Basin & Hispanic ATTC at UCC
• ATTC Regional Centers conducted recruitment
• Culturally matched Facilitators/Ambassadors led meetings
• Fieldworker/Note‐taker assisted at all meetings
Study Design‐ Overview
• 8 qualitative focus groups, 90 minutes each
• Four minority populations
– African American
– American Indian
– Asian American/Pacific Islander
– Hispanic/Latino
• 10‐12 participants per group using MAT for 6 months
• Outpatient behavioral health clinics & substance abuse 
treatment centers
• New York, Los Angeles (2), Honolulu, Chicago, 
Oklahoma City (2), Seattle
Study Design
• Recruitment: 
– Flyers and handouts in clinics
– $20 gift card incentives
• Procedures:
– Focus group guide directed conversation
– Information letters for participants
– Client information sheets (demographics)
– Pseudonyms chosen
– Meetings were digitally recorded (audio only)
– Refreshments provided
– Incentives given after the meeting
Participants
• 68 participants
– 15 African American 
– 18 Asian American 
– 19 Hispanic Latino 
– 16 Native American/
American Indian
• Primarily unemployed
• Mostly high school 
educated
0
2
4
6
8
10
12
14
Afr.
Am.
Asian
Am.
H/L Native
Am.
Female
Male
Transgender
Participants
0
5
10
15
20
25
20s 30s 40s 50s 60s 70s 80s
Age Distribution of Participants
Participants
Data Analysis
• Focus groups professionally transcribed
• Codebook developed for analysis 
– Code Examples:
• Benefits
• Ease of Access
• Self‐Efficacy
• Culture‐ Language
• Family Support
• Street Culture
• Fieldnotes & transcriptions coded by 3 researchers
Broad Themes
Benefits/Barriers related to MAT
Motivation to use MAT
Role of Family/Significant others
Access to treatment/Barriers
Self‐Efficacy
Influence of provider/clinic
MAT as drug v. MAT as medication
Surprising Results
! Weak emphasis on ethnic culture throughout most groups
! Strong emphasis on street/drug culture
! Definitions of “a good life”/motivations
! Family as a double‐edged sword
! Importance of “fictive kin” and clinic support
In Situ Particulars
• Participant lucidity
– Dosing
– “Nodding out”
• Children
• Ambient noise
• Room temperature
• Hostile participants
• Time constraints
• Late participants/Interruptions
Reflections/Recommendations
• Advantage of facilitator consistency 
v. facilitator specificity
• Broad v. local geographic sampling
• Saturation per cultural group
• Screening procedures (ethnicity v. 
culture)
Reflections/Recommendations
• Participant demographics (gender, age, type of 
substance)
• Remember discrepancies between research and 
practice
– Reading level of participant materials
– Un‐useful Incentives
• Importance of focus groups for 
emergent data
Agenda
• Overview of the Project
• Focus Group Findings
• Products Developed
• Next Steps
Products
Outreach Materials
• Brochures
• Pass‐along Cards
• Posters
• Website
2 Online Courses
• SUD Tx Providers
• Primary Care Practitioners
Outreach Materials
Brochure – Side 1
Outreach Materials
Brochure – Side 2
Outreach Materials
Pass–along Card
4 versions
Outreach Materials
Poster
4 versions
Outreach Materials
Spanish
versions
Online Courses
• 2 Self‐paced, online courses
o SUD Tx Providers (NAADAC, NBCC, IC & RC, NASW 
CEUs)
o Primary Care Practitioners (CMEs)
• 7 modules, 2 hours each
• Narrated Presentations, Videos, Readings, 
Quizzes, Homework
Online Courses
• 3 Core Modules
o Module 1 – context, epidemiology, effects of alcohol 
& opioids
o Module 2 – meds for alcohol and opioid addiction, 
introduction to findRXinformation.org, tx settings for 
MAT
o Module 3 – implementing MAT, recovery and MAT
• 4 Population‐specific Modules
o Module 4 – African Americans
o Module 5 – Asian/Pacific Islander
o Native American/American Indian Module
o Hispanic/Latino Module
Website (in development)
Find everything here
Agenda
• Overview of the Project
• Focus Group Findings
• Products Developed
• Next Steps
Next Steps – Data Directions
• Data used to inform development of 
recruitment/educational materials
• Data used to inform the development of a broad 
quantitative provider survey (in progress)
• Data currently being developed into two academic papers, 
one based upon focus group methodology, one focused on 
client identity and recovery
Next Steps – Product Dissemination
• Pilot test outreach materials (plan under 
development)
• Pilot test online courses (plan under 
development)
• Revise materials and courses as necessary
• Develop distribution plan for materials
• Develop marketing plan for courses
Panel Agenda
• About the Addiction Technology Transfer Center (ATTC) Network
• Setting the Context: Where are we with MAT?
• NIDA/SAMHSA Blending Initiative Overview: A focus on 
medication‐assisted treatment
• MAT in Special Populations
Panel Questions?
Olivia Ryan
ryanom@umkc.edu
Traci Rieckmann
rieckman@ohsu.edu
Thomas Freese
tfreese@mednet.ucla.edu
Beth Rutkowski
brutkowski@mednet.ucla.edu
Shawna Malvini Redden
shawna.malvini@asu.edu
Laurie Krom
kroml@umkc.edu
Closing the gap between research and practice:
Successful technology transfer strategies in combating
resistance to medication-assisted treatment

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ATTC Network Efforts to Combat Resistance to MAT (2011 AHSR Conference)