Diversity of hormone recepters
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Plus de Abdul Qahar {{Abdul Wali Khan University Mardan}} (Buner Campus)
Plus de Abdul Qahar {{Abdul Wali Khan University Mardan}} (Buner Campus) (20)
Diversity of hormone recepters
- 2. Name: Abdul QaharName: Abdul Qahar Presentation topic:diversity ofPresentation topic:diversity of hormone receptershormone recepters Presented to:Presented to: Sir, bakhtareen khan..Sir, bakhtareen khan.. ABDUL WALI KHAN UNIVERSITY MARDAN (BUNER CAMPUS)
- 3. What is hormone?What is hormone? What is the need of hormoneWhat is the need of hormone receptersrecepters??
- 5. 1. a protein molecule,present. on the surface of a cell, that is capable of binding to a complementary molecule, as a hormone, antibody, or antigen. • There are two functional clasess of recepters 1. Ionotropic 2. metabotropic
- 7. metabotropic
- 8. Location for different types ofLocation for different types of hormone:hormone: On the surface of the cellOn the surface of the cell membrane e.g.membrane e.g. proteins andproteins and polypeptidespolypeptides In the cell cytoplasmIn the cell cytoplasm steroidsteroid hormoneshormones In the cell nucleusIn the cell nucleus TT33 & T& T44
- 9. Hormone Receptor Cell membrane (surface/ inside) Inside cell (Cytoplasm/ Nucleus) HR Complex (Change in function of cell) Direct action 2nd Messenger System Action on Genetic Machinery Ion channels_ Linked receptors G-Proteins- Linked Receptors Enzyme- linked receptors Activation of genes cAMP Phspholipase C Ca++ -Calmodulin Protein synthesis Gene transcription 1 2 3 4 5 6 7
- 10. 1. Ion channel linked receptors are cell membrane bound receptors. They act through synaptic signaling on electrically excitable cells. The ion channels opening and closing is controlled by neurotransmitter
- 11. 2. G- Protein activation2. G- Protein activation
- 12. 3. Activation of intracellular3. Activation of intracellular enzymes (Leptin receptor)enzymes (Leptin receptor)
- 14. 4.Activation of genes (Steroids, thyroid hormones,4.Activation of genes (Steroids, thyroid hormones, retinoid hormone, vitamin D3)retinoid hormone, vitamin D3)
- 16. 557.→7.→Second Secondmessenger messengermechanism mechanism 1.1. cAMP cAMP (cGMP in some cases) (cGMP in some cases) 1.1. Calmodulin Calmodulin2.2. Membrane Membranephospholipids phospholipidsbreakdown products breakdown products(Phospholipase C 2 (Phospholipase C 2ndnd Messenger System) Messenger System)