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Adiba shabnam
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Depression has a major effect on the hippocampus. Studies have beyond doubt associated depression with reduced level of serotonin in the brain. It is for this reason that most of the treatments for depression are directed towards serotonin concentration enhancement in synaptic clefts. However, only 50% of the patients receiving the treatment responds and in the responding patients, although the rise in serotonin level is rapid, the complete evasion of the depressive symptoms takes weeks to months. However, Ketamine, an N-methyl-D-aspartate (NMDA) receptor antag- onist which leads to activation of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors has a fast and sustained antidepressive eect. So, research towards understanding the mechanism behind depression is now targeting gluta- matergic system too. Clinical evidence suggests decreased -aminobutyric acid (GABA) level in plasma, Cerebro Spinal Fluid (CSF) and brain of depressed patients. The proposed hypothesis is that these agents function together to reverse the biochemical changes due to depression. This experiment involves addition of 5-HT 1A agonist (8-OH DPAT) and 5-HT 2A/2C agonist (DOI) to cultured HT-22 cells and observing changes in m-RNA expression of AMPA receptors (GluR1, GluR2, GluR3 and GluR4), BDNF and GABAAalpha1 receptors.
Molecular mechanism underlying Depression: The relationship between serotonin...
Molecular mechanism underlying Depression: The relationship between serotonin...
Adiba shabnam
Metabolism, neurophysiology of Glutamate and GABA and their relevance in Psychiatry
Glutamate and GABA
Glutamate and GABA
Ooha Biddala
Glutamate and psychiatry
Glutamate and psychiatry
احمد البحيري
brief summary of serotonin receptors, treatment of migraine serotonin syndrome
Class serotonin and migraine 2
Class serotonin and migraine 2
Raghu Prasada
This is an overview of drugs used to treat migraine with an emphasis on serotonergic drugs. This presentation was for 2nd year pharmacy students as part of a pharmacology & toxicology course and accompanies Goodman & Gilman's (12e) chapter 46. A bit of general background on 5-HT is also included.
Migraine and 5-HT
Migraine and 5-HT
Brian Piper
Short review of serotonin receptors and new drugs targeting those receptors; various diseases related to serotonin and their pathophysiology.
Serotonin : diseases and therapeutics
Serotonin : diseases and therapeutics
Gaurav Yadav
5HT IN DETAIL
Serotonin receptors agonists & antagonists
Serotonin receptors agonists & antagonists
jireankita
serotonin
Hanipsych,,serotonin
Hanipsych,,serotonin
Hani Hamed
Recommandé
Depression has a major effect on the hippocampus. Studies have beyond doubt associated depression with reduced level of serotonin in the brain. It is for this reason that most of the treatments for depression are directed towards serotonin concentration enhancement in synaptic clefts. However, only 50% of the patients receiving the treatment responds and in the responding patients, although the rise in serotonin level is rapid, the complete evasion of the depressive symptoms takes weeks to months. However, Ketamine, an N-methyl-D-aspartate (NMDA) receptor antag- onist which leads to activation of -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors has a fast and sustained antidepressive eect. So, research towards understanding the mechanism behind depression is now targeting gluta- matergic system too. Clinical evidence suggests decreased -aminobutyric acid (GABA) level in plasma, Cerebro Spinal Fluid (CSF) and brain of depressed patients. The proposed hypothesis is that these agents function together to reverse the biochemical changes due to depression. This experiment involves addition of 5-HT 1A agonist (8-OH DPAT) and 5-HT 2A/2C agonist (DOI) to cultured HT-22 cells and observing changes in m-RNA expression of AMPA receptors (GluR1, GluR2, GluR3 and GluR4), BDNF and GABAAalpha1 receptors.
Molecular mechanism underlying Depression: The relationship between serotonin...
Molecular mechanism underlying Depression: The relationship between serotonin...
Adiba shabnam
Metabolism, neurophysiology of Glutamate and GABA and their relevance in Psychiatry
Glutamate and GABA
Glutamate and GABA
Ooha Biddala
Glutamate and psychiatry
Glutamate and psychiatry
احمد البحيري
brief summary of serotonin receptors, treatment of migraine serotonin syndrome
Class serotonin and migraine 2
Class serotonin and migraine 2
Raghu Prasada
This is an overview of drugs used to treat migraine with an emphasis on serotonergic drugs. This presentation was for 2nd year pharmacy students as part of a pharmacology & toxicology course and accompanies Goodman & Gilman's (12e) chapter 46. A bit of general background on 5-HT is also included.
Migraine and 5-HT
Migraine and 5-HT
Brian Piper
Short review of serotonin receptors and new drugs targeting those receptors; various diseases related to serotonin and their pathophysiology.
Serotonin : diseases and therapeutics
Serotonin : diseases and therapeutics
Gaurav Yadav
5HT IN DETAIL
Serotonin receptors agonists & antagonists
Serotonin receptors agonists & antagonists
jireankita
serotonin
Hanipsych,,serotonin
Hanipsych,,serotonin
Hani Hamed
.
Serotonin
Serotonin
Tehran University of Medical Sciences
The role of glutamate in patient with schizophrenia
Glutamate & schizophrenia
Glutamate & schizophrenia
Azimatul Karimah
Glutamate Theory in Schizophrenia
Glutamate 33
Glutamate 33
khalid mansour
Dr T Ravikanth, svs medical college, ap psychiatry
Serotonergic system ravi
Serotonergic system ravi
Prashant Mishra
AN OVERVIEW ON THE INVOLVMENT OF SEROTONIN (5-HT) IN CENTRALLY AND PERIPHERALLY MEDIATED PHYISIOLOGICAL FUNCTIONS
SEROTONIN (5-HT) NEUROTRANSMITTER