Parkinson's Disease

1. PARKINSON’S DISEASE
Alam Zeb
Roll no.09

2. Parkinsonism is a progressive
degenerative,disorder of muscle movement,
due to dysfunction in basal ganglia.
four cardinal features:
1.Bradykinesia or hypokinesia
2.Muscle rigidity
3.Resting tremor
4.Impairment of postural balance leading to
disturbances of gait, and falling.
 The secondary manifestations are mask-like face,
difficulty in speech, slowing of mental process and
dementia.
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3.  Degeneration of neurons in
the substantia nigra pars
compacta.
 Degeneration of nigrostriatal
(dopaminergic) tract
 Imbalance primarily between
the excitatory
neurotransmitter
Acetylcholine and inhibitory
neurotransmitter Dopamine
in the Basal Ganglia.

9.  Drugs that replace dopamine (Dopamine
precursor):
Levodopa
 Dopa-decarboxylase inhibitors (Drugs which
increase the central availability of Levodopa)
Carbidopa They act in the periphery as they do
not enter brain
 Drugs which increase release or inhibit
reuptake of dopamine (also called
dopamine facilitator)
Amantadine
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