Alcrea Health is the contract manufacturing division of Atrium Innovations – a developer, manufacturer and marketer of value added products for the cosmetic, pharmaceutical, chemical and nutritional industries. Caplique Liquid Capsules are a unique delivery form in dietary supplement industry. There are many custom nutritional supplement options when using this dosage form including color bandings and beadlet or time release technology. More at http://www.alcrea-health.com/products-liquid-capsules.html

1. Capabilities – Philadelphia
Caplique® Liquid Capsules

2. Alcrea Health & AquaCap
AquaCap was founded in 1998 and is located in Chadds Ford,
Pennsylvania. They are now a leading manufacturer of hard, two-piece,
liquid-filled capsules.
Available through contract manufacturing services with Alcrea Health,
this unique technology – originally developed for the pharmaceutical
industry – serves as an ideal delivery system for nutritional
supplements.

3. Manufacturing
Facility Overview
Capacity
• Main facility:
30,000 square feet
• Manufacturing Suite 1:
180 Million
• Off-site warehouse:
15,000 square feet
• Manufacturing Suite 2:
180 Million
• Manufacturing Suites: 4
• Manufacturing Suite 3:
360 Million
• Packaging Lines: 2 with
turnkey operations on site
• Manufacturing Suite 4:
360 Million
Total Capacity: 1.1 Billion

4. Commitment to Quality
Technical expertise formulation assistance
through on-staff PhDs
Ability to run small R&D samples prior to
full-scale production
Capsule compatibility testing

5. Commitment to Quality
Quality in accordance with USP/AOAC
methods where applicable
Product tested in ISO17025 Accredited Laboratories
• Microbiological Analysis
• Chemical Analysis
• Physical Analysis
Flexibility to align with customer requirements

6. ®
Caplique
Specifications
Common Liquids
Capsule Composition
• Krill Oil
• Cellulose
• Borage Oil
• Bovine
• Evening Primrose Oil
• Fish Gelatin
• Sesame Oil
• Olive Oil
• Saw Palmetto Oil
• Safflower Oil
• Fish Oil
• Hot melt/semi-solid

7. ®
Caplique
Specifications
Capsule Size
Packaging
• Typical fill weight ratio:
55% liquid to 45% solid
• Pressure Sensitive Labels
• Size 1: 375-425 mg
• Body Sleeves
• Size 0: 525-575 mg
• Bottle count ranging from
4 ct to 240 ct
• Size 00: 775-825 mg
• On-site Carton Machine

8. ®
Caplique
Difference
Band Sealing
Additional Options
• Does not utilize LEMS® process
of ethanol/water
• Time release beads
• No additional fillers required
• More natural application and
proven technology
Product Branding
• Color
• Printing
• Colored beads encapsulated in
a liquid medium
• Typical release profile: 6-8 hours
• Best suited for formulas requiring
low amounts of active ingredients

9. Benefits
Reduced number of excipients
Low oxidation
Supports bioavailability by promoting absorption
Typical disintegration in less than 10 minutes
Unique Dosage – Consumer can see the product

10. Hard Shell vs. Softgel
Characteristic
Hard Shell
Softgel
Ability to manufacture
small batches
Yes
No
Plasticizer in shell
No
Yes
Risk of active migration
(Leaching of plasticizer)
Low
High
Permeability to oxygen
Low
High
Sensitivity to heat and humidity
Low
High

11. Minimum Product Orders
Capliques® – 300,000
Color Banding – 300,000
Custom Stock Caplique® Colors – 300,000
(White, Red, Yellow, Royal Blue, Orange)
Custom Printed Caplique® – 1,000,000
Custom Beadlet Caplique® – Approximately 1,250,000

12. For additional questions or to discuss
a project, please contact:
Jessi Mingo, Manager, Business Development and Marketing
jmingo@alcrea-health.com • 412-722-0314