Full report here: https://amino.com/blog/chronic-gut-stomach-conditions-trends/ Amino’s report on chronic gut conditions aims to reveal what’s common and what to expect if you're diagnosed with the following conditions: acid reflux, ulcerative colitis, Crohn’s disease, irritable bowel syndrome (IBS), gallstones, celiac disease, and colon cancer. Amino also looked into data about colonoscopies, the most common screening procedure for many gut issues. All analyses were based off Amino’s database of more than 5 billion health care interactions representing more than 188 million Americans. Within this database, Amino saw 4.7 million patients who were diagnosed with one of the seven aforementioned gut conditions between January 2014 and December 2015.

1. What Amino's database reveals about
chronic gastrointestinal conditions
Full report available at amino.com/blog
March 2016
America’s Gut Check

2. Celiac disease
Crohn's disease
Colon cancer
Irritable bowel syndrome
Ulcerative colitis
Gallstones
Acid reflux
0 1 M 2 M
© 2016 AMINO INC.
ACID REFLUX RANKS HIGHEST ON OUR LIST OF GUT CONDITIONS
Patients diagnosed with select gut conditions in 2014 & 2015
BASED ON 4,719,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE
2.56 M
1.05 M
501 k
344 k
326 k
267 k
53 k

3. © 2016 AMINO INC.
MORE WOMEN ARE DIAGNOSED WITH GUT CONDITIONS THAN MEN
Patients diagnosed with select gut conditions in 2014 & 2015
Celiac disease
Crohn's disease
Colon cancer
Irritable bowel syndrome
Ulcerative colitis
Gallstones
Acid reflux
0.0 500.0 k 1.0 M 1.5 M
Male
Female
BASED ON 4,719,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE

4. © 2016 AMINO INC.
ACID REFLUX MOST COMMONLY AFFECTS INFANTS & PEOPLE OVER 50
Distribution of 2,564,700 patients diagnosed with acid re!ux, by age
Patient age
BASED ON 2,564,700 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH ACID REFLUX BETWEEN 2014 & 2015
0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
Male
Female

5. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
WOMEN GET DIAGNOSED WITH IBS NEARLY 3X MORE THAN MEN
Distribution of 344,300 patients diagnosed with irritable bowel syndrome (IBS), by age
Male
Female
Patient age
BASED ON 344,300 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH IBS BETWEEN 2014 & 2015

6. © 2016 AMINO INC.
FOR EVERY ONE MAN, 2.9 WOMEN ARE DIAGNOSED WITH IBS
Relative comparison of patients diagnosed with select gut conditions in 2014 & 2015
Men
BASED ON 4,188,200 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE
Women
Irritable bowel syndrome
Celiac disease
Gallstones
Acid re!ux
Crohn’s disease
2.9x
2.3x
2.1x
1.5x
1.2x

7. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
ULCERATIVE COLITIS DIAGNOSES DOUBLE FROM AGE 14 TO 20
Distribution of 501,100 patients diagnosed with ulcerative colitis, by age
Male
Female
Patient age
BASED ON 501,100 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH ULCERATIVE COLITIS BETWEEN 2014 & 2015

8. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
GALLSTONES DIAGNOSES INCREASE 4X FOR WOMEN FROM AGE 17 TO 30
Distribution of 1,050,800 patients diagnosed with gallstones, by age
Male
Female
Patient age
BASED ON 1,050,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH GALLSTONES BETWEEN 2014 & 2015

9. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
CROHN’S DISEASE DIAGNOSES DOUBLE FROM AGE 14 TO 20
Distribution of 266,900 patients diagnosed with Crohn’s disease, by age
Male
Female
Patient age
BASED ON 266,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH CROHN’S DISEASE BETWEEN 2014 & 2015

10. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
MEN GET DIAGNOSED WITH COLON CANCER MORE THAN WOMEN
Distribution of 326,000 patients diagnosed with colon cancer, by age
Male
Female
Patient age
BASED ON 326,000 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH COLON CANCER BETWEEN 2014 & 2015

11. 0.0%
0.5%
1.0%
1.5%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
WOMEN GET DIAGNOSED WITH CELIAC DISEASE 2X MORE THAN MEN
Male
Female
Patient age
Distribution of 52,900 patients diagnosed with celiac disease, by age
BASED ON 52,900 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE DIAGNOSED WITH CELIAC DISEASE BETWEEN 2014 & 2015

12. 0%
1%
2%
3%
0 10 20 30 40 50 60 70 80
© 2016 AMINO INC.
GOOD NEWS! AMERICANS FOLLOW COLONOSCOPY GUIDELINES
Distribution of 5,964,800 patients who received a colonoscopy, by age
Patient age
BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015
Male
Female

13. 2.8 M
3.2 MFemale
Male
0 1 M 2 M 3 M
© 2016 AMINO INC.
WOMEN GET COLONOSCOPIES MORE THAN MEN
Patients receiving a colonoscopy between 2014 & 2015
BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015

14. Female
Male
0% 25% 50% 75% 100%
© 2016 AMINO INC.
BIOPSIES & REMOVAL OF POLYPS ARE COMMON DURING COLONOSCOPIES
Percent of patients receiving a colonoscopy by type
BASED ON 5,964,800 DISTINCT U.S. PATIENTS IN AMINO’S DATABASE WHO RECEIVED A COLONOSCOPY BETWEEN 2014 & 2015
Screening Screening with biopsy and/or removal Other
60.3%36.1%
43.5% 53.5%

15. Full report + an interactive chart that shows you how
gut conditions are related to other health issues
available at amino.com/blog