Scientists commonly find themselves in a state of overwhelm in regards to the availability of information accessible to them. The distribution of resources now includes the entire space of the worldwide web, access to primary databases such as CAS and, commonly, a plethora of internally developed systems. While the web has provided improved access to chemistry-related information there has not been an online central resource allowing integrated chemical structure-searching of chemistry databases, chemistry articles, patents and web pages such as blogs and wikis. ChemSpider has built a structure centric community for chemists by providing free access to an online database and collaboration tool for chemists. The online database offers an environment for curating the data on ChemSpider as well as the deposition of chemical structures, analytical data and associated information and provides a significant knowledge base and resource for chemists working in different domains. An overview of present and future capabilities is given.

1. ChemSpider Building a Structure Centric Community for Chemists Antony Williams CINF: Chemometrics: From Teaching to Research; April 5 th 2008, ACS New Orleans

6. Example Search 1

7. Example Search 1

9. Example Search 2

10. Complex Search

11. Search Open Access Journals – ChemSpider

12. Search PubMed – ChemSpider

15. Quality is a Major Issue- Search Butanol

18. Multi-level Curation and Approval

21. Adding to the Database - Structure

22. Adding New Text Data Add Publication Add Identifier Add URL

23. Adding Supplementary Info to a Structure

29. LASSO Descriptors on ChemSpider 14 Million molecules have descriptors (so far)

31. LASSO Searching Method 2

34. Screening for weak ER binders Percent of database % of actives recovered

47. Out of 1 Year Beta Release Today New Website Release (today/tonight…)