The document discusses Artialis' expertise in motion and gait analysis for both preclinical and clinical applications. It has developed innovative equipment and platforms using 3D motion capture, force plates, electromyography, and isokinetic evaluation to assess muscle strength, gait, and rehabilitation outcomes in a comprehensive manner. This allows for tracking of motion in health and disease from basic research to clinical patient monitoring.

1. The understanding and tracking of motion is very interesting in
health and disease. It can be applicable to a large range of
musculoskeletal diseases in animals or in humans from elite sport
performance to the clinical follow up of patients during
rehabilitation after traumatism.
Building on its expertise in the evaluation of osteoarthritis, Artialis
has developed a strong network of partners and innovative
equipment for the assessment or rehabilitation of muscle strength in
pre-clinical or clinical trials.
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
Motion and gait analysis
Artialis new offer
1. PRECLINICAL OFFER:
CatWalk XT 10.5 Noldus - Advanced Gait Analysis System for rodent
Video-based advanced gait analysis system to:
• Dynamically measure footprints of a voluntary
moving animal
• Assess locomotion deficits and pain syndromes in
animal models (mouse, rat, guinea pig)
• Individual paws – paw statistics
• Spatial relationship between paws – step sequence, base of support, print positions
• Temporal relationship between paws – Phase dispersions, couplings
• Other statistics – Average speed, cadence, Sciatic Functional Index, contact of other body
parts with the glass plate
• System (Run) Variables – Camera gain, run average duration, Green intensity Threshold, Red
ceiling voltage, Green walkway intensity, calibration units
Batka, R.J. et al., The need for speed in rodent locomotion analyses. Anat. Rec. (Hoboken). 2014; 297: 1839–1864
Ying-Ju Chen et al., Detection of subtle neurological alterations by the Catwalk XT gait analysis system. J Neuroeng
Rehabil. 2014; 11: 62.
References:
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2. ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
A. OARSI recommended basic tests for gait analysis
2. CLINICAL OFFER:
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3. 1. 3D Motion Capture of the gait cycle
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
4CX1 Codamotion units:
Optoelectronic system allowing
3D localization of active markers
placed on different parts of the
body (knee, ankle, great
trochanter, pelvis, foot…)
 Quantification of the
orientation and rotation of the
body segments
• Racetrack (technical floor) of 35 meters long
• 4 Coda motion units allowing Kinematic
measurement of all directions of the motion
• Joint angle trajectories calculated by
combination of the information (orientation
and rotation) of adjacent segments
• Measures performed by comparison between
both limbs and also with reference to a
healthy population
• Active markers emitting their own infrared
light avoid signal misinterpretation but limit
the number of markers used simultaneously
and need to connect electric cable
• The frequency of data acquisition depends on
the number of markers
 56 markers limit the frequency to 100 Hz
 6 markers limit the frequency to 800 Hz
Analysis of the gait cycle
The 3D Codamotion CX1 system is the gold standard in research-grade Lab and portable 3D motion
analysis systems. It provides the user with marker accessories, analysis protocols and report
templates that ensure consistent and reliable gait analyses every time.
Information that can be obtained:
• Positions in space
• Speeds of the legs
• Rotations in different spatial axes
• Angular velocities
Foot analysis during the gait cycle
Active-marker based technology -> high data reliability
and minimal data processing time
B. Innovative technological platforms
for gait and motion analysis
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728 3 of 8

4. Pression Force
Reaction Force
Lateral force
• 2 Force plates integrated in the walkway
to measure ground reaction forces
(e.g. gait, jumping or running)
• The force plates can be moved (on rail)
along the walkway
• Measures ground reaction differences
between the two feet
2. Force plateforms
Information that can be obtained:
• Pushing forces according to the three spatial axes
• Ground contact time
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
Kistler piezoelectric force platforms:
• Measure the ground reaction forces and moments as a person moves across them
• Enables clinicians to fully assess the external forces acting on a person, to the internal muscle
and joint contact forces via musculoskeletal modeling
• Can be synchronized with the Coda motion capture system
• Platforms are portable allowing to reposition the platform on the walkway to obtain data from
various activities (walking, running, up and down stairs…)
Force analysis of one step while walking
B. Innovative technological platforms
for gait and motion analysis
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5. Gastrocnemius muscle
Tibialis anterior
Hamstrings
Quadriceps
• 16 Surface wireless electrodes attached to the
skin overlying the muscle belly
• Measure up to 16 muscles without interfering
with locomotion
• Muscle function can be evaluated through the
analysis of the timing and amplitude of the
electrical activity coinciding with force
generation during the gait analysis
• Muscles recruitment and control for the
achievement of specific movements
3. Electromyography
Information that can be obtained:
• Muscle contraction relative intensity
Muscular activity assessment during gait
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
Biofeedback applications:
• Training of specific muscles
• Ergonomic assessments that establish
the degree to which muscles contract or
relax
• Biomechanics investigations that
determine the role that individual
muscles have in contribution to joint
torque
• …
Comparing muscles activation intervals of a pathological
gait from a patient before or after treatment reveals
how the duration of contractions and the timing changes
B. Innovative technological platforms
for gait and motion analysis
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6.  Combination and synchronization of all data
with the Codamotion Analysis software
during one exercise providing a global
overview of the activity
 Tests can be performed on the floor (walking test, sit & stand up tests) or on stairs
OARSI recommended
on a treadmill for endurance studies (tilt 15°, max speed 24 km/h)
on an ergometric bicycle
 A complete exam (motion, pressure and muscular activity) will last 1h30
 All in 1 solution
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
3D Coda
Sensor
Unit
Force Plates
EMG
Coda
Software for
modeling
analysis
B. Innovative technological platforms
for gait and motion analysis
Cliodhna Ni Scanaill et al. Technology Innovation Enabling Falls Risk Assessment in a Community Setting. Ageing Int.
2011 Jun; 36(2): 217–231.
Eveline De Raeve et al., The use of a robotic gait simulator for the development of an alignment tool for lower limb
prostheses. J Foot Ankle Res. 2014; 7(Suppl 1): A15.
References:
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7. Cybex HUMAC CSMI
• Dynamometric measure of the maximal force couple developed by a muscular group during a
volunteer dynamic contraction
• Variable resistance instantly adapts to the strength of torque developed by the muscle group
studied on the entire range of motion and at a predetermined constant speed thanks to
electromagnetic brakes
• Allows rehabilitation and muscle reconditioning of peripheral joints and spine
• Objectively determine the strength, velocity and fatigability parameters for different muscle
groups by comparison side-by-side in order to demonstrate an imbalance or weakness
4. Isokinetic evaluations
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
Rehabilitation exercises as isokinetic tests are critical to restore efficient range of motion,
reduce the levels of muscle weakening and imbalances, eliminate bad postural behaviors
and maintain good coordination.
Moreover, isokinetic programs are recommended as resistance training on patients with
articular cartilage injury due to the speed and smoothness of the movement decreasing the
stress.
These exercises can significantly help in pain control and improving quality of life of the
patient.
B. Innovative technological platforms
for gait and motion analysis
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8. Fixing the speed allows maximum neuromuscular contraction
High security in case of pain and Decrease the risk of overload
Adapts to the muscular fatigue
Evaluations can be performed in eccentric or concentric mode
Allow the evaluation of both muscular and articular pathologies provoking limitations in
movement
Tests protocols are selected in function of the pathology and the deficit to measure
Results interpretation can be done in function of various parameters:
-> force-speed relation, instantaneous analysis of force moments curve, bilateral comparison,
comparison to standards
Allow the assessment of various parts of the body:
-> shoulder, elbow, wrist, hip, knee, ankle or lumbar spine
For the knee joint evaluation, a surface electromyography EMG can be added for the study of
muscles recruitment, the beginning and the end of activation of the muscles of interest
EXTENSION / FLEXION PRONE
TIBIAL INTERNAL / EXTERNAL ROTATION
HIP:
ABDUCTION / ADDUCTION
FLEXION / EXTENSION
INTERNAL / EXTERNAL ROTATION
ARTIALIS S.A., 11 Avenue de l’Hôpital, Sart-Tilman, tour GIGA, 4000 LIEGE – Belgium Tel : 0032(0)4 2427706– Fax : 0032(0)4 2427728
4. Isokinetic evaluations
KNEE:
EXTENSION / FLEXION SEATED
B. Innovative technological platforms
for gait and motion analysis
Croisier JL et al. Strength imbalances and prevention of hamstring injury in professional soccer players: a prospective
study. Am J Sports Med. 2008 Aug; 36(8):1469-75.
Cherian JJ. et al. Prospective Case Series of NMES for Quadriceps Weakness and Decrease Function in Patients with
Osteoarthritis of the Knee. J Long Term Eff Med Implants. 2015;25(4):301-6.
References:
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