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Transdel Pharmaceuticals, Inc . ,[object Object],[object Object]
Safe Harbor Statement ,[object Object]
Transdel Investment Highlights ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transdel Management Team ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidermis Dermis Subcut. Tissue Muscle Transdermal Delivery System (TDS) ,[object Object],[object Object],[object Object],[object Object],[object Object],Transdel’s proprietary cream formulation enables active drug  to penetrate the skin and reach targeted underlying tissue
Selected Pipeline *TDB – To Be Determined Program Target Status Partner(s) Launch Date Ketotransdel Pain (NSAID) Phase III TBD* TDLP310 Cellulite Subject Trials JH Direct & Jan Marini Skin Research Anticipate 2010 TDLP320 Anti-Aging Formulation TBD* TDLP330 Pigmentation Formulation TBD*
Therapeutic Value of Topical NSAIDs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Massey T, et al., Topical NSAIDs for acute pain in adults (Review),  published in The Cochrane Library 2010, Issue 6
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Lead Pain Drug Ketotransdel
Clinical Design:    Randomized, double-blind, placebo-controlled Study Population:  Patients with acute soft tissue injuries    (sprains & strains) Indication:  Relief of pain from acute soft tissue injuries Dosing Regimen:  Ketotransdel vs. Placebo (Vehicle) cream,  1g three times daily over 7 days Primary Endpoint:  Change from baseline in pain intensity on    Day 3 Visit (+1, +2 days) with VAS measurement Secondary Endpoints: Safety assessments, various other efficacy variables  Pharmacokinetics in subset of patients Clinical Sites: 26 (USA) Randomized: N=364 Ketotransdel   Phase 3 Trial
Ketotransdel demonstrated statistically significant  higher reduction in pain intensity from baseline in both the modified Intent-To-Treat (ITT) and Per Protocol (PP) analysis. PP (n=252) mITT (n=326) Mean reduction from baseline in mm (100 mm Visual Analogue Scale)   mm Reduction   in Pain Intensity from baseline on Day 3 Ketotransdel Phase 3 Trial TDLP-110-001:   Primary Efficacy Endpoint Results  *  p < 0.05 *  p = 0.038 * A nalysis of all  ITT patients who met study entry criteria ,  ANCOVA on change from baseline in pain intensity during daily  activities  over the past 24 hours on Day 3 Visit (Day 3, +1 or +2 days)
Ketotransdel Phase 3 Trial TDLP-110-001: Efficacy Endpoint:  Change from baseline in  three-times-daily pain intensity The Pain Curves over time show  consistent separation between treatment groups reaching statistical significance in favor of Ketotransdel in ITT analyses . * Time period that primary endpoint “Day 3 Visit” covers: Days 3, 4 and 5. * Ketotransdel Placebo
[object Object],[object Object],[object Object],[object Object],[object Object],Ketotransdel Phase 3 trial TDLP-110-001:  Safety and Pharmacokinetics Ketotransdel  (n= 182) Placebo  (n=182) All potentially related AEs: 4.1% 3.8% 4.4% Cutaneous/application site AEs 1.1 % 2.2%
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Ketotransdel Phase 3 trial TDLP-110-001 Conclusions
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Patients Who May Benefit From  a Topical NSAID
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],*Source: U.S. Transdermal Drug Delivery Markets, Frost and Sullivan, August 2006. Ketotransdel Market Opportunity
[object Object],[object Object],[object Object],[object Object],Note: Graphs denote total prescriptions, per IMS data. Total  Rx COX2s Vs. NSAIDs Topical NSAID (Diclofenac) TRx NSAID Market Dynamics
Competitive Landscape  FDA Approved Topical NSAIDs Product Indication Dosage Company Flector Patch 1.3% diclofenac  Acute Pain (strains & sprains) 10 x 14 cm patch, 2 times per day  King Pharma/ IBSA Voltaren Gel 1% diclofenac Osteoarthritis knee/ hands 2- 4 g qid (16g/d) ENDO/ Novartis Pennsaid 1.5% diclofenac Osteoarthritis knee 40 drops of liquid (10 drops to each of 4 sides of knee), 3-4 times per day  Covidien/ NUVO
US Sales of Flector Patch and Voltaren Gel  (in millions) FY 2008 FY  2009 FY 2010 (E) Flector Patch (1) $ 128  $ 139  $  180 Voltaren Gel (1) $  24  $  79 $  96 Pennsaid (2) – – N.A. $ 152  $  218  $  276 ,[object Object],[object Object],[object Object],Double digit growth estimated in 2010 for Flector and Voltaren Gel
Cosmeceuticals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Select Financials Key Statistics Symbol: TDLP.OB Fiscal Year End: December 31 st Current Price (6/17/10): $1.20 Shares Outstanding: 15.7 million Market Cap: $19 million Proforma cash (as of 3/31/10) (1) $2.0 million ( 1) Includes $1M proceeds from convertible senior promissory note issued in April 2010.
Contact Us Transdel Pharmaceuticals, Inc . (OTC BB: TDLP.OB) 4225 Executive Square Suite 485 La Jolla, CA 92037 Corporate Headquarters Investor Contact John Lomoro Chief Financial Officer and Acting Chief Executive Officer (858) 457-5300 [email_address] Please visit www.transdelpharma.com for more information.

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Transdel Pharmaceuticals Inc., (TDLP.OB)

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  • 6. Selected Pipeline *TDB – To Be Determined Program Target Status Partner(s) Launch Date Ketotransdel Pain (NSAID) Phase III TBD* TDLP310 Cellulite Subject Trials JH Direct & Jan Marini Skin Research Anticipate 2010 TDLP320 Anti-Aging Formulation TBD* TDLP330 Pigmentation Formulation TBD*
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  • 9. Clinical Design: Randomized, double-blind, placebo-controlled Study Population: Patients with acute soft tissue injuries (sprains & strains) Indication: Relief of pain from acute soft tissue injuries Dosing Regimen: Ketotransdel vs. Placebo (Vehicle) cream, 1g three times daily over 7 days Primary Endpoint: Change from baseline in pain intensity on Day 3 Visit (+1, +2 days) with VAS measurement Secondary Endpoints: Safety assessments, various other efficacy variables Pharmacokinetics in subset of patients Clinical Sites: 26 (USA) Randomized: N=364 Ketotransdel Phase 3 Trial
  • 10. Ketotransdel demonstrated statistically significant higher reduction in pain intensity from baseline in both the modified Intent-To-Treat (ITT) and Per Protocol (PP) analysis. PP (n=252) mITT (n=326) Mean reduction from baseline in mm (100 mm Visual Analogue Scale) mm Reduction in Pain Intensity from baseline on Day 3 Ketotransdel Phase 3 Trial TDLP-110-001: Primary Efficacy Endpoint Results * p < 0.05 * p = 0.038 * A nalysis of all ITT patients who met study entry criteria , ANCOVA on change from baseline in pain intensity during daily activities over the past 24 hours on Day 3 Visit (Day 3, +1 or +2 days)
  • 11. Ketotransdel Phase 3 Trial TDLP-110-001: Efficacy Endpoint: Change from baseline in three-times-daily pain intensity The Pain Curves over time show consistent separation between treatment groups reaching statistical significance in favor of Ketotransdel in ITT analyses . * Time period that primary endpoint “Day 3 Visit” covers: Days 3, 4 and 5. * Ketotransdel Placebo
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  • 17. Competitive Landscape FDA Approved Topical NSAIDs Product Indication Dosage Company Flector Patch 1.3% diclofenac Acute Pain (strains & sprains) 10 x 14 cm patch, 2 times per day King Pharma/ IBSA Voltaren Gel 1% diclofenac Osteoarthritis knee/ hands 2- 4 g qid (16g/d) ENDO/ Novartis Pennsaid 1.5% diclofenac Osteoarthritis knee 40 drops of liquid (10 drops to each of 4 sides of knee), 3-4 times per day Covidien/ NUVO
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  • 20. Select Financials Key Statistics Symbol: TDLP.OB Fiscal Year End: December 31 st Current Price (6/17/10): $1.20 Shares Outstanding: 15.7 million Market Cap: $19 million Proforma cash (as of 3/31/10) (1) $2.0 million ( 1) Includes $1M proceeds from convertible senior promissory note issued in April 2010.
  • 21. Contact Us Transdel Pharmaceuticals, Inc . (OTC BB: TDLP.OB) 4225 Executive Square Suite 485 La Jolla, CA 92037 Corporate Headquarters Investor Contact John Lomoro Chief Financial Officer and Acting Chief Executive Officer (858) 457-5300 [email_address] Please visit www.transdelpharma.com for more information.