This document analyzes human factors that predict failure and success in implementing hospital information systems in sub-Saharan Africa. It studied 19 implementation projects and identified 14 potential failure factors and 15 success factors through staff interviews and project evaluations. High predictive failure factors included resignation to poor quality, psychological issues, siloed culture, unrealistic timelines, poor training and support. High success predictive factors included clear communication, realistic timing, process changes, stakeholder agreement, and quick wins. The document concludes many commonly assumed factors like skills, incentives and consideration of current practices did not show predictive value.