1. Redefining Tissue Regeneration
1

2. 2
Motivation
Regenerative Medicine:
Help the body heal itself
Help the body heal itself
Only faster

3. Assembly of 3D porous structures
incorporating a pre-vascular network
with several applications in tissue regeneration.
Biopolymer
or
biopolymer
and ceramic
Pre-vascular
network
Technology
Intellectual Property - patent and trademarks
(disclosure form was submitted to the University TTO)
3

4. Orthopedics
Veterinary Dentistry
Plastic Surgery
Technology’s Applications
4

5. Bone volume lost due to trauma,
tumors or congenital disorders.
Problem
5
Slow regeneration due to the
lack of a vascular network to
nourish the cells.
Brydone, 2010

6. Current practice
BONE GRAFTING
2.2 million
surgical procedures
every year.
Giannoudis et al., 2005 6

7. Autograft: The gold standard solution
7
Donor site
complications
Limited availability
Multiple surgeries

8. Other Solutions
Proteins
Allograft (cadaver)
Synthetic
Long regeneration time Very expensive
Limited availability
… Less than ideal solutions!
8

9. Pre-vascular network
Adjustable to the
grafting site
Always ready for
use
Ortho NovaOss
Faster bone regeneration (2-3x)
“The product sounds extremely promising.”
Charles N. Cornell, Clinical Director of Orthopedic Surgery
(Hospital for Special Surgery, New York , US #1 in Orthopedics)
9
No rejection risk

10. BENEFITS
Autograft
(patient’s
own bone)
Proteins
Allograft
(cadaver)
Synthetic
Ortho
NovaOss
Vascularization Vascularized Not vascularized
Pre-vascular
Network
Shapable Difficult Yes No Yes
Availability 2 surgeries
Very
expensive
Limited Unlimited Unlimited
Ortho NovaOss vs Other Solutions
10

11. Alternative to autografts
Easier to treat larger defects
Surgeon
Distributors
Easy to handle
Valuable product
Hospitals / Clinics / Insurers
Less surgeries and faster recovery means
Patient Less surgeries
Less post-op complications
Improved quality of life
Faster tissue
regeneration
Benefits of Ortho NovaOss
Easy storage
11
Simpler interventions
Ortho
NovaOss
Less expenses

12. Hospitals
and
Physicians
Operations
Distributer
12

13. Marketing Strategy
13
Workshops
- Trainings
- Seminars
Trade Shows
- Ortho Tec Europe
Conferences
- Annual Meeting AAOS
- Bone Tec

14. Roadmap
14
2011 2012 2013 2014 2015 2016 2017
Proof of concept
Intellectual Property Rights
Regulatory issues
Ortho NovaOss
Market entry
Supplementary claim
through EMA and FDA
PT
SP
FR
DE
UK
IRL
Equivalency claim
through EMA and FDA
USEU
(other)

15. EU
9.3%
US
1.6%
Orthopedics – € 74 000M
Bone Grafts
€ 7 400M
Synthetic +
Allograft
€ 4 000M
15
Market - 2017

16. Financials
16
Payback: 6 yearsFunding Requirement: €2.0 M EBIDTA/Sales: 30%

17. 2018- Dentistry
2020 – Orthopedics - Spinal fusion
Spinal NovaOss
Dental NovaOss
17
Future Directions

18. CEO
CFO
COOCTO
R&D Operations managerAdministrative manager
IP
Company structure
Jorge Carvalho
Silva
João Paulo
Borges
Célia Henriques Sara Ferreira
Dina Chaves
Catarina MadeiraSara Reis Carlos João
18

19. Redefining Tissue Regeneration
“This indeed sounds very good”
Robert Meek
(Orthopaedic and Trauma, Southern General Hospital, Glasgow, UK)
“Your work elaborates exactly the area of interest for
orthopedic surgeons”
Philipp Lichte
(Department of Trauma Surgery, University Hospital of the RWTH Aachen, Aachen, GER)
19
infonovatissue@gmail.com