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By Juliane Ried 1, Gavin Stewart 2, David Hives 2, Martin Janczyk 3, Lorne Becker 4 1 Cochrane Innovations, Germany; 2 The Cochrane Library, Wiley, UK; 3 Cochrane Web Team, Germany; 4 Cochrane Innovations, USA
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This is my presentation to the Bio Open Source Convention (BOSC) in Boston, July 2010. I start with a brief status-update on the BioMoby project and then launch into a series of demonstrations of it's successor - SADI + SHARE. Rather than discussing how SADI/SHARE work, I focus the discussion on what role I think these technologies can play in bringing the traditional "scientific method" back into in silico biology.
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Professor Marcus Müllner of the Austrian Agency for Health and Food Safety (AGES) presents "Does evidence-based decision making exist?" at the opening of the Austrian Cochrane Branch on December 14th, 2010 in Krems.
2. Opening of the Austrian Cochrane Branch - Marcus Muellner
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Professor Ruth Gilbert of University College London presents "Could a systematic review have prevented the epidemic of sudden infant death syndrome?" at the opening of the Austrian Cochrane Branch in Krems, Austria, on December 14th 2010.
3. Opening of the Austrian Cochrane Branch - Ruth Gilbert
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Introduction and welcome to the opening by Dr. Kylie Thaler, Associate Director of the Austrian Cochrane Branch. Followed by a presentation by Sir Iain Chalmers on the James Lind Library initiative. December 14th, 2010, In Krems, Austria.
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1. Opening of the Austrian Cochrane Branch - Iain Chalmers
Cochrane.Collaboration
Dr. Gerd Antes, Director of the German Cochrane Centre, presents "Evidenz ist essentiell - von der Idee zum globalen Netzwerk: Die Cochrane Collaboration".
5. Opening of the Austrian Cochrane Branch - Gerd Antes
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Dr. Wolfgang Gaissmaier of the Max Planck Institute presents "Warum wir verständliche Informationen brauchen".
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3. Opening of the Austrian Cochrane Branch - Ruth Gilbert
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1. Opening of the Austrian Cochrane Branch - Iain Chalmers
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5. Opening of the Austrian Cochrane Branch - Gerd Antes
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4. Opening of the Austrian Cochrane Branch - Wolfgang Gaissmaier
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Cochrane Database of Systematic Reviews: Indexing, Citations & Bibliometrics
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Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma.
Shazia Iqbal 2024 - Bioorganic Chemistry.pdf
Shazia Iqbal 2024 - Bioorganic Chemistry.pdf
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In this captivating lecture, Dr. Faiza, an esteemed Assistant Professor of Physiology, embarks on a comprehensive journey into the multifaceted realm of local blood flow regulation. With meticulous detail and clarity, she unravels the intricate mechanisms that govern the dynamic balance between tissue perfusion and vascular resistance, shedding light on both acute and chronic aspects of blood flow control. Beginning with an exploration of acute influences, Dr. Faiza elucidates how physiological factors such as metabolic demand, myogenic responses, and autoregulatory mechanisms orchestrate rapid adjustments in local blood flow. Students gain insight into the vasodilator theory, which elucidates the role of metabolic byproducts and vasoactive metabolites in promoting vasodilation, alongside the oxygen demand theory, which underscores the interplay between tissue oxygenation and nutrient demand. Delving deeper, the lecture delves into the fascinating realm of humoral control, where hormones and vasoactive substances wield significant influence over vascular tone. Dr. Faiza navigates through the intricacies of endothelial-derived factors like nitric oxide (NO) and histamine, alongside hormonal regulators such as angiotensin II and vasopressin. Through vivid explanations and illustrative examples, she unveils the intricate dance of vasodilation and vasoconstriction orchestrated by these biochemical messengers. Moreover, the lecture extends its gaze to the extrinsic control of blood flow, where sympathetic innervation exerts a profound impact on vascular dynamics. Dr. Faiza elucidates the role of sympathetic tone in modulating vascular resistance, highlighting its implications in diverse physiological and pathological scenarios. From skin perfusion to coronary circulation, students gain a nuanced understanding of how neural inputs shape local blood flow patterns. Enriched with clinical insights and contemporary research findings, this lecture equips students with a holistic understanding of blood flow regulation. By exploring concepts like active and reactive hyperemia, vascular remodeling, and collateral circulation, Dr. Faiza fosters a deeper appreciation for the adaptive responses of the cardiovascular system to changing physiological demands and pathological insults.
Control of Local Blood Flow: acute and chronic
Control of Local Blood Flow: acute and chronic
MedicoseAcademics
Dr Assadawy lectures
tongue disease lecture Dr Assadawy legacy
tongue disease lecture Dr Assadawy legacy
DrMohamed Assadawy
In this lecture on circulatory shock, Dr. Faiza, an Assistant Professor of Physiology, delves into the profound implications of inadequate blood flow throughout the body, leading to tissue damage. The session begins by defining circulatory shock and elucidating its physiological causes, including decreased cardiac output, diminished blood volume, decreased vascular tone, obstruction to blood flow, excess metabolic rate, and abnormal perfusion patterns. Dr. Faiza categorizes shock into various types, such as cardiogenic shock, hypovolemic shock, neurogenic shock, obstructive shock, anaphylactic shock, and septic shock, and explores the pathophysiological basis of each. Furthermore, the lecture examines the stages of shock, from the non-progressive phase where compensatory mechanisms aim for full recovery to the progressive phase where shock worsens steadily without intervention, potentially leading to irreversible damage. Dr. Faiza discusses therapeutic interventions for shock, including replacement therapy, blood and plasma transfusion, sympathomimetic drugs, and other adjunctive treatments like head-down positioning, oxygen therapy, and glucocorticoids.
Circulatory Shock, types and stages, compensatory mechanisms
Circulatory Shock, types and stages, compensatory mechanisms
MedicoseAcademics
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ANATOMY AND PHYSIOLOGY OF RESPIRATORY SYSTEM.pptx
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Gastric Cancer: Сlinical Implementation of Artificial Intelligence, Synergeti...
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Crowdsourcing and Cochrane
1.
Crowdsourcing and Cochrane Draw
me a sheep…
2.
Crowdsourcing is… very popular
3.
Crowdsourcing is…
4.
Amazon Mechanical Turk HITs
= Human Intelligence Tasks
5.
Draw me a
sheep TheSheepMarket.com is a collection of 10, 000 sheep made by workers on Amazon’s Mechanical Turk.
6.
Using the crowd
for science Zooniverse www.zooniverse.org
7.
Biology
8.
Biology • One single
account • “dive on in”
9.
Biology • One single
account • “dive on in” “this commitment to producing real research – so that you know we’re not wasting your time – is at the heart of everything we do”
10.
Citizen science http://www.scistarter.com/
11.
Slick process 1 2 3
12.
Why consider it Producing
vast amounts of evidence Quality vs Speed vs Capacity
13.
How could it
work? One BIG task Smaller tasks Nano tasks Clinically relevant question which needs an answer
14.
Where are we
headed? Embase: becomes an integral part of your day Screen 5 citations per day x 31 000 contributors
15.
Currently… QReview group The life of
a clinically relevant question
16.
Could try… QReview group The life
of a clinically relevant question
17.
Or this… Q The life
of a clinically relevant question Review group T a s k
18.
Or this… QReview group T a s kQReview group The life
of a clinically relevant question
19.
QReview group T a s kQReview group T a s k T a s k T a s k The life of
a clinically relevant question
20.
QReview group T a s kQ T a s k T a s k T a s k Q Review group Review group The life of
a clinically relevant question
21.
3 key ingredients Needed Doable Motivated Supported Slick Versatile
22.
Thank you
23.
Acknowledgements Rupert McShane Caroline Struthers Kit
Huckvale
Notes de l'éditeur
Perhaps one day we’ll see Cochrane Zoo!
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