1. DISRUPTIVE
INNOVATIONS
Disruptive Innovation:
Moving Beyond the Talk
Thomas Krohn
Eli Lilly & Company

2. Case for Disruptive Innovation
Source: FDA.gov
Productivity Down, Costs Up Future revenues under pressure
Unsustainable Business Model

3. The Far Side
by Gary Larson

4. Drug Development
$-
$100
$200
$300
MillionsUS$
Typical Cost/NME/Phase
Precompetitive Competitivepatent
Innovation Process

5. 3 Challenges
• Incremental vs. Disruptive
• Precompetitive vs. Competitive
• Closed vs. Open

6. Incremental Improvement

8. Clinical Research Improvement
Good, but not sufficient

9. Disruptive Innovation
to S1'
to S2
S1
Time
Performance
Disruptive
Change
Simpler, Faster, Cheaper?
Who is being disrupted?

10. Precompetitive vs. Competitive
Precompetitive Competitive
Collaboration should and can exist across model
patent

11. Closed vs. Open
Trial Planning & Design Example
Reality
• Distant from practice
• Small number
• Slow and expensive
• Naïve
Today’s Closed Fortress Model:
• Internal product teams
• Advisors
• Third party organizations
• Competitive = Secret
Time to explore other models

12. Experiment Portfolio
• Open Clinical Intelligence Network
– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

13. Open Clinical Intelligence Network
Commons Licensing
3. Curate
4. Connect1. Collect
Clinical
Knowledge
Generation
2. Consume
Uncurated
Data
Curated
Data
Crowd
Public Data
Motivation
Technology
Worldbank
ROAR

14. Open Clinical Intelligence Network
Knowledge Generating System
Krohn & Crist Whitepaper
Trial
Site
Publication
Drug
Disease
Regulatory
Timeline
Geographic
Network Diagram
Scatter Plot
Export
API
Search/Filter
Annotate
Correct
Cross Link
API
Social Share
Collaborate
External Data
Gamification
Commons Licensing
3. Curate
4. Connect1. Collect
Clinical
Knowledge
Generation
2. Consume
Uncurated
Data
Curated
Data
Crowd
Public Data

15. From data to insights

16. Experiment Portfolio
• Open Clinical Intelligence Network
– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design
– Crowd-based feedback

17. Protocol Design

18. Experiment Portfolio
• Open Clinical Intelligence Network
– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design
– Crowd-based feedback
• Site Training & Experience
– Credentials, Training, Historical Trials
• Predictive Analytics
– Kaggle style enrollment projections

19. Predictive Analytics
We’re making data science a sport.™

20. Experiment Portfolio
• Open Clinical Intelligence Network
– Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI
• Protocol Design
– Crowd-based feedback
• Site Training & Experience
– Credentials, Training, Historical Trials
• Predictive Analytics
– Kaggle style enrollment projections
• Q&A Forum
– Site to site sharing, clinical research topics

21. Q&A Forum

22. So What?
If...
– Incremental improvement is a slow death,
– Competitive mindset is stopping collaboration, and,
– Closed model is part of the problem…
Then…check your assumptions:
– Incremental vs. Disruptive
– Precompetitive vs. Competitive
– Closed vs. Open

23. Time to Engage!
Tide is rising for disruptive change.
Are you on board?
The case is clear
The opportunities are many
The question is leadership

24. Thanks
Thomas Krohn
krohnta@lilly.com
Eli Lilly and Company
www.lillycoi.com