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Osteoporosis andOsteoporosis and
Bone Densitometer
CM-200
Furuno Electric Co., Ltd.
JAPAN
FURUNO ELECTRIC CO., LTD. All Rights Reserved.
Osteoporosis and our target sales routeOsteoporosis and our target sales route
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 1
H t M ?H t M ?
全身DXA
How to Measure?How to Measure?
DXA(Dual energy X-ray Absorptiometry)
DXA(D l X Ab ti t )
末梢DXA(橈骨など)
全身DXA
(腰椎、大腿骨近位部など)
( gy y p y)
Peripheral part
DXA(Dual energy X-ray Absorptiometry)
Lumbar spine, femoral neck
MD、DIP(中指骨)
MD(Micro Densitometry),
DIP(Digital Image Processing)
Mid finger
QUS (Q tit ti Ult S d)
QUS(踵骨)
QUS (Quantitative UltraSound)
Calcaneus
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 2
P f H lth BP f H lth BPurpose for Healthy BonePurpose for Healthy Bone
・ Prevail the awareness of potential
fracture risk caused by Osteoporosis.
・ QUS for “screening”, and
DXA f “d fi iti di i ”DXA for “definitive diagnosis”.
"Earl screening and earl treatment“・ "Early screening, and early treatment“
for the prevention of the fracture risk.
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 3
E l 1 (M t f i )E l 1 (M t f i )Example1 (Measurement for mass screening)Example1 (Measurement for mass screening)
Group screening by Doctor's diagnosis
QUS device
g
OrOr
QUS device is suitable for mass
screening, for its easy operation
d i k t ti
Detailed examination
by DXA Treatment with
and quick measurement time.
After the screening, some patient
might need detailed examination
by DXA and other patient start
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 4
y eat e t w t
medication
by DXA, and other patient start
medical treatment under doctor's
diagnosis.
E l 2 (Di i b i t li i )E l 2 (Di i b i t li i )Example2 (Diagnosis by private clinic)Example2 (Diagnosis by private clinic)
Treatment with
medicationQUS device measurement
by clinic doctor
Measurement cost of QUS device is low
compared with DXA, and the device is
ll f d b i t d t f
Doctor's diagnosis
generally preferred by private doctor for
the usage of the osteoporosis diagnosis.
The doctor prescribes a treatment drug
based on the whole diagnosis such as QUS
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 5
based on the whole diagnosis such as QUS
measurement result or health history of
the patient.
Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)
Part of Promotion
QUS device measurement
Part of Promotion
by pharmaceutical company
Treatment with one’s own product
Some pharmaceutical company uses QUS
devices for the promotion purpose of their
d t h t t t d f
(medicine, or supplement)
product such as treatment drug of
osteoporosis or calcium supplement.
Usually, these companies conduct the
measurement for free in a hospital place and
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 6
measurement for free in a hospital place, and
apply the drug or supplement to the person who
suspected to have osteoporosis.
D f T ti O t iD f T ti O t iDrug for Treating OsteoporosisDrug for Treating Osteoporosis
Method Therapeutic Drug Therapeutic EfficacyMethod Therapeutic Drug Therapeutic Efficacy
Injection Teriparatide Accelerates the formation of new bone.
Injection Calcitonin Alleviation of pain caused by osteoporosis.Injection Calcitonin Alleviation of pain caused by osteoporosis.
Prevent the breaking of old bone.
Internal use
Drip infusion
Bisphosphonate Prevent the breaking of old bone.
Drip infusion
Internal use selective estrogen receptor
modulator 【SERM】
Prevent the breaking of old bone.
Injection Anti-RANKL Antibody Prevent the loss of calcium from bones.
Internal use Activated Vitamin D Enhances absorption of calcium from food substance,
and accelerates the formation of new bone.and accelerates the formation of new bone.
Internal use Vitamin K Accelerates the formation of new bone.
Internal use Calcium Supplies Calcium as additional nutrition
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 7
Introduction of CM-200
Ul d b d iUltrasound bone densitometer
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 8
Steady Sales PerformanceSteady Sales Performance
CM-100 & CM-200
Volume of shipment (oversea)CM-100 & CM-200 Volume of shipment (oversea)CM 100 & CM 200
Cumulative Sales Data
PRODUCT CM-100 CM-200
CHINA 19 492CHINA 19 492
INDIA 0 69
VIETNAM 1 18
TAIWAN 43 10
MALAYSIA 0 4MALAYSIA 0 4
PHILIPPINES 2 8
UAE 0 2
KSA 0 2
KUWAIT 0 1KUWAIT 0 1
BRAZIL 0 1
SRI LANKA 0 1
KOREA 183 0
INDONESIA 1 0INDONESIA 1 0
PAKISTAN 2 0
EGYPT 9 0
JAPAN 2198 1563
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 9
TOTAL 2458 2171
TOTAL:4629
(as of end of Jan, 2014)
Comparison chartComparison chartComparison chartComparison chart
Manufacturer FURUNO OsteoSys GE
Model CM-200 SONOST-3000 Achilles EXPII
Measurement Site Calcaneus (Heel Bone) Calcaneus (Heel Bone) Calcaneus (Heel Bone)
Parameter SOS SOS /BUA SOS/BUA
Results
T-score with % young adult
Z-score with % age-matched
BQI Index
T-score with % young adult
Z-score with % age-matched
Stiffness Index
T-score with % young adult
Z-score with % age-matched
H l T C ti H l T S N NHeel Temp. Compensation Heel Temp. Sensor No No
Scanning Time Less than 10 sec Less than 15 sec Less than 10 sec
Precision < 0.5% CV (in vitro) < 2.0% CV ( in vivo) < 2.0% CV ( in vivo)
Foot Plate Adjustable plate structure (5 levels) Replaceable plate Replaceable plate
Measurement block Full dry coupling with Ultrasound Gel Full dry coupling with Ultrasound Gel using alcohol and silicon membrane
Probe Movement Manual Motorized (automatic adjustment)
Fixed probe,
Expandable membrane with water
External Monitor support Standard Component Option Option
Built-in Printer Thermal Printer Thernal Printer Thernal Printer
Display Color LCD Color LCD Color LCD
Dimension (mm) 510 x 300 x 210mm 300 x 620 x 390 mm 281 x 305 x 560 mm
Weight 11 kg 12kg 11.5 kgg g g g
Consumable Parts Thermal Printer paper Thermal Printer paper Thermal Printer paper, silicon membrane
MODEL
FURUNO ELECTRIC CO., LTD. All Rights Reserved.
PICTURE
Safety and Speedy measurementSafety and Speedy measurement
S f tSafety
Ultrasound method requires no special facilities. With
radiation exposure-free, it allows to all generation
including children to pregnant women to measure.
SpeedySpeedy
Approx. 10 seconds required for measurement.
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 11
Result DisplayResult Display
C l h f lt i di l d f ltColor graph of result is displayed for easy result
monitoring.
Simple Print-out Sheet
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 12
Precision measurement (H l t t )Precision measurement (Heel temperature sensor)
Thi d i f ti d l d b FURUNOThis new and unique function developed by FURUNO
provides accurate results by offsetting the result with
heel temperat reheel temperature
Heel
Temperature
Sensor
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 13
Precision measurement (H l t t )
Temperature sensor - ON
Precision measurement (Heel temperature sensor)
Temperature sensor- OFFTemperature sensor - ON
1570
1580
1590
1600
Temperature sensor OFF
1570
1580
1590
1600
1530
1540
1550
1560
1570
OS[m/s]
1530
1540
1550
1560
1570
SOS[m/s]
OCT
JAN
OCT
JAN
1490
1500
1510
1520
SO
1480
1490
1500
1510
1520
S
JAN
FEB
JULY
AUG
MAR
APR
JAN
FEB
JULY
AUG
MAR
APR
1470
1480
1470
1480
1490
1500
1510
1520
1530
1540
1550
1560
1570
1580
1590
1600
SOS (Sep.) [m/s]
1470
1480
1470
1480
1490
1500
1510
1520
1530
1540
1550
1560
1570
1580
1590
1600
SOS (Sep.) [m/s]
AUG
1:1
AUG
1:1
 When the temperature sensor is ON, results is on the green line which
shows the ideal condition The feature enables accurate SOS
FURUNO ELECTRIC CO., LTD. All Rights Reserved.
shows the ideal condition. The feature enables accurate SOS
measurement regardless of seasonal condition.
14
Precision measurement (F t Si Adj t t)
Th f t l t b dj t d t 5 l l b
Precision measurement (Foot Size Adjustment)
The foot plate can be adjusted to 5 levels by
operating the dial, and makes more accurate measure
at the best position of heel in an eas operationat the best position of heel in an easy operation.
(19cm, 20cm, 21cm, 22 to 24cm and above 25cm) .
Provides accurate SOS for children.
Study show most of 10-year-old children have footStudy show most of 10-year-old children have foot
size above 19cm.
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 15
Utility Software
C t CM 200 t t l PC
Utility Software
Connect CM-200 to an external PC.
Type patient information and click Start button on a
PC screen.
Measurement results will be saved on PC and
managed as the PC file.
Result graph, trend graph and QC graph can beResult graph, trend graph and QC graph can be
printed from the printer connected to the PC.
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 16
Utility SoftwareUtility Software
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 17
SpecificationsSpecifications
Measurement Site Heel (Calcaneas)S ( )
Measurement Method Ultrasound Pulse Penetration
Measuring Parameter SOS:Speed of Sound
Measurement Time Approx. 10 SecMeasurement Time pp
Measurement Precision
%CV Less than 0.5%
(in measurement of Phantom)
Ultrasound Frequency Center Frequency: 500 kHz
Ultrasound Output Isptp: 1.8mW/cm2
Measurement Block Dry Type (acoustic gel used)
Operating Environment
Temperature: 10 - 35°C
Operating Environment
Humidity: 30 – 85%RH (Non Condensing)
Storage Environment
Temperature: -10 - 50°C
Humidity: 30 - 85%RH (Non Condensing)
Power Supply 220VAC±10%pp y
Rated Frequency 50Hz/60Hz
Consumption Current 0.3A or less
Dimensions 510 (W) x 300 (W) x 210 (H) mm
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 18
Mass 11 kg (Approximately)
Thank you for your attentionThank you for your attentionThank you for your attentionThank you for your attention
FURUNO ELECTRIC CO., LTD. All Rights Reserved. 19

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Ultrasound Bone Densitometer

  • 1. confidential Osteoporosis andOsteoporosis and Bone Densitometer CM-200 Furuno Electric Co., Ltd. JAPAN FURUNO ELECTRIC CO., LTD. All Rights Reserved.
  • 2. Osteoporosis and our target sales routeOsteoporosis and our target sales route FURUNO ELECTRIC CO., LTD. All Rights Reserved. 1
  • 3. H t M ?H t M ? 全身DXA How to Measure?How to Measure? DXA(Dual energy X-ray Absorptiometry) DXA(D l X Ab ti t ) 末梢DXA(橈骨など) 全身DXA (腰椎、大腿骨近位部など) ( gy y p y) Peripheral part DXA(Dual energy X-ray Absorptiometry) Lumbar spine, femoral neck MD、DIP(中指骨) MD(Micro Densitometry), DIP(Digital Image Processing) Mid finger QUS (Q tit ti Ult S d) QUS(踵骨) QUS (Quantitative UltraSound) Calcaneus FURUNO ELECTRIC CO., LTD. All Rights Reserved. 2
  • 4. P f H lth BP f H lth BPurpose for Healthy BonePurpose for Healthy Bone ・ Prevail the awareness of potential fracture risk caused by Osteoporosis. ・ QUS for “screening”, and DXA f “d fi iti di i ”DXA for “definitive diagnosis”. "Earl screening and earl treatment“・ "Early screening, and early treatment“ for the prevention of the fracture risk. FURUNO ELECTRIC CO., LTD. All Rights Reserved. 3
  • 5. E l 1 (M t f i )E l 1 (M t f i )Example1 (Measurement for mass screening)Example1 (Measurement for mass screening) Group screening by Doctor's diagnosis QUS device g OrOr QUS device is suitable for mass screening, for its easy operation d i k t ti Detailed examination by DXA Treatment with and quick measurement time. After the screening, some patient might need detailed examination by DXA and other patient start FURUNO ELECTRIC CO., LTD. All Rights Reserved. 4 y eat e t w t medication by DXA, and other patient start medical treatment under doctor's diagnosis.
  • 6. E l 2 (Di i b i t li i )E l 2 (Di i b i t li i )Example2 (Diagnosis by private clinic)Example2 (Diagnosis by private clinic) Treatment with medicationQUS device measurement by clinic doctor Measurement cost of QUS device is low compared with DXA, and the device is ll f d b i t d t f Doctor's diagnosis generally preferred by private doctor for the usage of the osteoporosis diagnosis. The doctor prescribes a treatment drug based on the whole diagnosis such as QUS FURUNO ELECTRIC CO., LTD. All Rights Reserved. 5 based on the whole diagnosis such as QUS measurement result or health history of the patient.
  • 7. Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company)Example3 (Drag or supplement promotion by pharmaceutical company) Part of Promotion QUS device measurement Part of Promotion by pharmaceutical company Treatment with one’s own product Some pharmaceutical company uses QUS devices for the promotion purpose of their d t h t t t d f (medicine, or supplement) product such as treatment drug of osteoporosis or calcium supplement. Usually, these companies conduct the measurement for free in a hospital place and FURUNO ELECTRIC CO., LTD. All Rights Reserved. 6 measurement for free in a hospital place, and apply the drug or supplement to the person who suspected to have osteoporosis.
  • 8. D f T ti O t iD f T ti O t iDrug for Treating OsteoporosisDrug for Treating Osteoporosis Method Therapeutic Drug Therapeutic EfficacyMethod Therapeutic Drug Therapeutic Efficacy Injection Teriparatide Accelerates the formation of new bone. Injection Calcitonin Alleviation of pain caused by osteoporosis.Injection Calcitonin Alleviation of pain caused by osteoporosis. Prevent the breaking of old bone. Internal use Drip infusion Bisphosphonate Prevent the breaking of old bone. Drip infusion Internal use selective estrogen receptor modulator 【SERM】 Prevent the breaking of old bone. Injection Anti-RANKL Antibody Prevent the loss of calcium from bones. Internal use Activated Vitamin D Enhances absorption of calcium from food substance, and accelerates the formation of new bone.and accelerates the formation of new bone. Internal use Vitamin K Accelerates the formation of new bone. Internal use Calcium Supplies Calcium as additional nutrition FURUNO ELECTRIC CO., LTD. All Rights Reserved. 7
  • 9. Introduction of CM-200 Ul d b d iUltrasound bone densitometer FURUNO ELECTRIC CO., LTD. All Rights Reserved. 8
  • 10. Steady Sales PerformanceSteady Sales Performance CM-100 & CM-200 Volume of shipment (oversea)CM-100 & CM-200 Volume of shipment (oversea)CM 100 & CM 200 Cumulative Sales Data PRODUCT CM-100 CM-200 CHINA 19 492CHINA 19 492 INDIA 0 69 VIETNAM 1 18 TAIWAN 43 10 MALAYSIA 0 4MALAYSIA 0 4 PHILIPPINES 2 8 UAE 0 2 KSA 0 2 KUWAIT 0 1KUWAIT 0 1 BRAZIL 0 1 SRI LANKA 0 1 KOREA 183 0 INDONESIA 1 0INDONESIA 1 0 PAKISTAN 2 0 EGYPT 9 0 JAPAN 2198 1563 FURUNO ELECTRIC CO., LTD. All Rights Reserved. 9 TOTAL 2458 2171 TOTAL:4629 (as of end of Jan, 2014)
  • 11. Comparison chartComparison chartComparison chartComparison chart Manufacturer FURUNO OsteoSys GE Model CM-200 SONOST-3000 Achilles EXPII Measurement Site Calcaneus (Heel Bone) Calcaneus (Heel Bone) Calcaneus (Heel Bone) Parameter SOS SOS /BUA SOS/BUA Results T-score with % young adult Z-score with % age-matched BQI Index T-score with % young adult Z-score with % age-matched Stiffness Index T-score with % young adult Z-score with % age-matched H l T C ti H l T S N NHeel Temp. Compensation Heel Temp. Sensor No No Scanning Time Less than 10 sec Less than 15 sec Less than 10 sec Precision < 0.5% CV (in vitro) < 2.0% CV ( in vivo) < 2.0% CV ( in vivo) Foot Plate Adjustable plate structure (5 levels) Replaceable plate Replaceable plate Measurement block Full dry coupling with Ultrasound Gel Full dry coupling with Ultrasound Gel using alcohol and silicon membrane Probe Movement Manual Motorized (automatic adjustment) Fixed probe, Expandable membrane with water External Monitor support Standard Component Option Option Built-in Printer Thermal Printer Thernal Printer Thernal Printer Display Color LCD Color LCD Color LCD Dimension (mm) 510 x 300 x 210mm 300 x 620 x 390 mm 281 x 305 x 560 mm Weight 11 kg 12kg 11.5 kgg g g g Consumable Parts Thermal Printer paper Thermal Printer paper Thermal Printer paper, silicon membrane MODEL FURUNO ELECTRIC CO., LTD. All Rights Reserved. PICTURE
  • 12. Safety and Speedy measurementSafety and Speedy measurement S f tSafety Ultrasound method requires no special facilities. With radiation exposure-free, it allows to all generation including children to pregnant women to measure. SpeedySpeedy Approx. 10 seconds required for measurement. FURUNO ELECTRIC CO., LTD. All Rights Reserved. 11
  • 13. Result DisplayResult Display C l h f lt i di l d f ltColor graph of result is displayed for easy result monitoring. Simple Print-out Sheet FURUNO ELECTRIC CO., LTD. All Rights Reserved. 12
  • 14. Precision measurement (H l t t )Precision measurement (Heel temperature sensor) Thi d i f ti d l d b FURUNOThis new and unique function developed by FURUNO provides accurate results by offsetting the result with heel temperat reheel temperature Heel Temperature Sensor FURUNO ELECTRIC CO., LTD. All Rights Reserved. 13
  • 15. Precision measurement (H l t t ) Temperature sensor - ON Precision measurement (Heel temperature sensor) Temperature sensor- OFFTemperature sensor - ON 1570 1580 1590 1600 Temperature sensor OFF 1570 1580 1590 1600 1530 1540 1550 1560 1570 OS[m/s] 1530 1540 1550 1560 1570 SOS[m/s] OCT JAN OCT JAN 1490 1500 1510 1520 SO 1480 1490 1500 1510 1520 S JAN FEB JULY AUG MAR APR JAN FEB JULY AUG MAR APR 1470 1480 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 SOS (Sep.) [m/s] 1470 1480 1470 1480 1490 1500 1510 1520 1530 1540 1550 1560 1570 1580 1590 1600 SOS (Sep.) [m/s] AUG 1:1 AUG 1:1  When the temperature sensor is ON, results is on the green line which shows the ideal condition The feature enables accurate SOS FURUNO ELECTRIC CO., LTD. All Rights Reserved. shows the ideal condition. The feature enables accurate SOS measurement regardless of seasonal condition. 14
  • 16. Precision measurement (F t Si Adj t t) Th f t l t b dj t d t 5 l l b Precision measurement (Foot Size Adjustment) The foot plate can be adjusted to 5 levels by operating the dial, and makes more accurate measure at the best position of heel in an eas operationat the best position of heel in an easy operation. (19cm, 20cm, 21cm, 22 to 24cm and above 25cm) . Provides accurate SOS for children. Study show most of 10-year-old children have footStudy show most of 10-year-old children have foot size above 19cm. FURUNO ELECTRIC CO., LTD. All Rights Reserved. 15
  • 17. Utility Software C t CM 200 t t l PC Utility Software Connect CM-200 to an external PC. Type patient information and click Start button on a PC screen. Measurement results will be saved on PC and managed as the PC file. Result graph, trend graph and QC graph can beResult graph, trend graph and QC graph can be printed from the printer connected to the PC. FURUNO ELECTRIC CO., LTD. All Rights Reserved. 16
  • 18. Utility SoftwareUtility Software FURUNO ELECTRIC CO., LTD. All Rights Reserved. 17
  • 19. SpecificationsSpecifications Measurement Site Heel (Calcaneas)S ( ) Measurement Method Ultrasound Pulse Penetration Measuring Parameter SOS:Speed of Sound Measurement Time Approx. 10 SecMeasurement Time pp Measurement Precision %CV Less than 0.5% (in measurement of Phantom) Ultrasound Frequency Center Frequency: 500 kHz Ultrasound Output Isptp: 1.8mW/cm2 Measurement Block Dry Type (acoustic gel used) Operating Environment Temperature: 10 - 35°C Operating Environment Humidity: 30 – 85%RH (Non Condensing) Storage Environment Temperature: -10 - 50°C Humidity: 30 - 85%RH (Non Condensing) Power Supply 220VAC±10%pp y Rated Frequency 50Hz/60Hz Consumption Current 0.3A or less Dimensions 510 (W) x 300 (W) x 210 (H) mm FURUNO ELECTRIC CO., LTD. All Rights Reserved. 18 Mass 11 kg (Approximately)
  • 20. Thank you for your attentionThank you for your attentionThank you for your attentionThank you for your attention FURUNO ELECTRIC CO., LTD. All Rights Reserved. 19