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Integration of Full-Coverage Probabilistic Functional Networks with Relevance to Specific Biological Processes   James, K., Wipat, A. & Hallinan, J. School of Computing Science, Newcastle University Data Integration in the Life Sciences 2009
Integrated functional networks ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dataset bias ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Bias in HTP datasets From  Myers and Troyanskaya, Bioinformatics 2007.
Bias & Relevance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hypothesis ,[object Object]
Network integration
Network integration
Effect of D value
Relevance scoring ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Relevance scoring
Data sets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Choice of D value ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Classifier output classification threshold positives negatives TP TN FP FN Increasing specificity Increasing sensitivity
ROC Curves
D value
D value
Ranking 3 3 2 8 4.2253   8 1 1 1 7 4.4641   7 7 8 5 6 4.5212   6 5 5 7 5 4.9335   5 4 4 3 4 5.0842   4 2 2 6 3 5.7040   3 8 7 8 2 5.7054   2 6 6 4 1 6.6937   1 A&T Rank Telomere Rank Ageing Rank Conf. Rank Conf. Score Dataset
Results
Evaluation - Clustering ,[object Object],[object Object]
Results 38.35 33.33 29.83 24.67 523 R 37.98 33.80 29.55 24.26 573 C C 8.59 8.90 7.73 6.50 508 R 6.53 7.02 6.14 5.06 573 C T 36.92 31.75 27.73 22.37 523 R 35.19 28.86 26.14 21.29 573 C A >4 nodes >3 nodes >2 nodes % COI Clusters Bias Net
Cluster annotation
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Future work ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object]

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