Frederic Lluis - Investigador principal en KU Leuven.
Trastornos del sueño y Autismo
1. Milagros Merino Andreu Unidad Pediátrica de Trastornos de Sueño Programa de Medicina del Sueño
2.
3.
4.
5. SUEÑO NORMAL EN NIÑOS Iglowstein et al. Pediatrics, 2003; 11: 302-307 2 siestas 1 siesta 2 siestas 1 siesta percentiles
6.
7.
8.
9.
10.
11.
12.
13. AGENDA DE SUEÑO Agenda de sueño = herramienta útil para evaluar la magnitud del problema y evaluar la eficacia de los tratamientos
14. En UNIDADES de SUEÑO ACTIGRAFÍA Brouillette et al. Pediatrics 2000 PULSIOXIMETRÍA POLISOMNOGRAFÍA Oyane et al. 2005
15.
16. Anomalías epileptiformes intercríticas: 43-68% (1-5 % en niños sin autismo) EEG en AUTISMO Che et al, 2004; Tuchman et al, 2002-2010; Cavazzuti et al, 1980; Lee et al, 2011; Yosuhara 2011; Nomura et al, 2010; Parmegianni et al, 2011 Superposición autismo-epilepsia Autismo Epilepsia EPOCS ERBI TD SLK
24. PARASOMNIAS 1. PARASOMNIAS EN SUEÑO NREM (TRASTORNOS DEL AROUSAL): 1º tercio de la noche. Benignas, amnesia del episodio, ojos abiertos, “desorientados” Despertares confusionales (muy frecuentes en menores de 5 años), Sonambulismo (4-12 años), Terrores nocturnos (3-7 años). 2. PARASOMNIAS EN SUEÑO REM: Ultimo tercio de la noche - Pesadillas (menores de 5 años) - Trastorno de comportamiento en sueño REM: raro en niños, se asocia a TEA y encefalopatías. Comportamientos complejos durante el sueño REM, con ausencia de atonía muscular y agresividad (estudios contradictorios, con IRS 1 o sin tratamiento 2 ) Schreck et al, 2000; Honomichl et al, 2002; Thirumalai et al, 2002 1 ; Malow et al, 2006 2
25.
26.
27.
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
Notes de l'éditeur
Sleep problems are commonly reported in children with autistic and____ disorders.
May have similar epileptiform activity like in Landau Kleffner syndrome over the perysilvian areas, although in 75% of the patients may have this type of activity outside these areas. None of the children with autism had more than four cycles, whereas all the control children had 5 or more.
Overlap autismo-epilepsia. TD: Trast Dsintegrativo (es un tipo de TGD), AV: agnosia verbal.
From a survey of 226 children with autism. The newsletter of autism society. 10% of these were sever and 22% moderate.
Estudio de Galland: 22 pacientes, IAH > 1
Estudio de Turkdogan: cuestionario a 4346 escolares 10-14 a, luego cuestionario especifico: SPI = 2,74%, DC = 54,5% de los SPI, AF = 16%
In the first study, the children’s sleep problems had previously failed to be alleviated by behavioural management techniques. One had 16 children with autism and was also randomized, double-blind, placebo-controlled crossover The other had 25 children with autism, but there was no placebo control group and melatonin was combined with behavioural techniques, making it difficult to assess the effect of melatonin on sleep. All children improved with melatonin treatment. Sleep problems returned in 16 out of 25 children when melatonin was discontinued but re-administration of melatonin was effective again. Treatment gains were maintained at 12 and 24-month follow-ups.
There are some obvious disadvantages to chronotherapy though; it is labour intensive and requires around the clock monitoring. It would be very disruptive to a family’s daily schedule and is not possible to do if the child has to go to school during the day.
There are some obvious disadvantages to chronotherapy though; it is labour intensive and requires around the clock monitoring. It would be very disruptive to a family’s daily schedule and is not possible to do if the child has to go to school during the day.
![¿QUÉ ES EL AUTISMO (TEA)? ,[object Object],[object Object],[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)