1. Modern
CANCER PREVENTION
Approach
A Science Premier
Mr. LEE Chee Cheow (M.Sc.) Chief Scientific Officer,
International Advanced Bio-Pharmaceutical Industries Pte Ltd.
Dr Lee Chee Wee (Ph.D.) Chief Scientific Advisor, IABPI Pte Ltd
Adjunct Associate Professor, YLL School of Medicine, NUS
Promoting the Nutriceutical Science of Preventive Self-care

2. Cancer:
Number 1 Killer Disease in Modern Society
Major causes of death in Singapore
About 1 in 3
(31%)
Deaths is from Cancer
•Source: Registry of Birth & Deaths

3. Ten Most Frequent Cancers in Singapore Males,
2006 -2010
Singapore Cancer Registry ; Interim Annual Registry Report ;
Trends in Cancer Incidence in Singapore 2006-2010

4. Ten Most Frequent Cancers in Singapore Females
2006 – 2010
Singapore Cancer Registry ; Interim Annual Registry Report ;
Trends in Cancer Incidence in Singapore 2006-2010

5. Our Immunity decline : As we age
Diseases of
aging
Incidents increase
exponentially with
age

6. Cancer : A Disease of aging
incidents increase exponentially with age
Colorectal Cancer

7. Cancer – Disease of aging
incidents increase exponentially with age
Lung Cancer

8. Cancer – Disease of aging
incidents increase exponentially with age
Liver Cancer

9. Recommendation 1:
As you get older
Get Screened More Regularly
 To discover the cancer early
 Screening should include:
 Skin
 Mouth
 Colon
 Rectum
 Prostate
 Testes
 Cervix
 Breast

10. The role of
environment
and genes in the
development of
cancer

11. Genes
associated
with risk of
different
cancers

12. Recommendation 2:
Know Your Personal & Family History
Take preventive measure to avoid Hereditary Cancers
Common hereditary cancers:
 Breast cancer
 Ovarian cancer
 Colorectal cancer
 Prostate cancer
Genetic testing:
 Breast (BRCA1 & 2)
 Ovarian (BRCA1 & 2)
 Colorectal (MLH1 & MSH2)
 Prostate (6 potential genes)

13. Cancer is A Largely Avoidable Disease
 Up to 4/5 (90%) of cancer
may be prevented through
environment & lifestyle
modifications
 1/3 (33%) of these cancer
occurrences can be
minimized via dietary
modifications and/or
enhancement

14. Recommendation 3:
Avoid Tobacco &
Alcohol
Cancers that
have been linked
to alcohol and
smoking
Increase cancer risk if exceeded:
 2 drinks a day for man
 1 drink a day for woman
 1 drink a day if about 65 yrs old

15. Obesity Increases Cancer Risks
Type of Cancer Exercise Reduction of Proportion of incidence
Cancer risks1 attributed to Obesity2
Colon Cancer 30-40% 11%
Breast Cancer 20-80% 9%
Endometrial Cancer 20-40% 39%
Lung Cancer 20% -
Kidney Cancer NA 25%
Esophageal Cancer NA 37%
Gall Bladder Cancer NA 24%
Source:
1. US National Cancer Institute: Fact sheet; Physical Activity and Cancer
2. Australia Cancer Council: National Cancer Prevention Policy; Preventable risk factors; Overweight & obesity

16. Summary of Mortality from Cancer According to Body-Mass Index for U.S. Men in the Cancer Prevention Study II, 1982 through 1998.

17. Summary of Mortality from Cancer According to Body-Mass Index for U.S. Women in the Cancer Prevention Study II, 1982 through 1998.

18. Recommendation 4:
Stay Active &
Maintain a Healthy
Weight
Cancers
that linked
to obesity
Physically active for 30 min
or more on most days of
the week
 Low-key activities
 Brisk walking
 Swimming
 Tai Chi
 Ballroom dancing

19. Cancers that
linked to
infection

20. HBV DNA Levels and Liver Cancer

21. Recommendation 5: Get Immunized
 Hepatitis B
Liver cancer
 Human papillomavirus (HPV)
Cervical cancer
Also cancers of anus, penis,
throat, vulva & vagina

22. Recommendation 6:
Avoid Behaviors that can lead to infections
Viruses transmitted sexually or by
sharing contaminated needles:
Human Papillomavirus (HPV)
• Cervical cancer, cancers of anus, penis, throat, vulva &
vagina
HIV (AIDS)
• Anal cancer, cervical cancer, liver cancer & lymphoma etc
Hepatitis B and C
• Liver cancer

23. Cancers that
linked to
environmental
carcinogens

24. Recommendation 7:
Avoid Environmental Risks
 Known carcinogens
 Gasoline
 Diesel exhaust
 Arsenic
 Vinyl chloride
 Nickel chromates
 Coal products
 Mustard gas
 Chloromethyl ethers
 Radiation
 Mobile phone?!?!
•0 min •15 min

25. Recommendation 8:
Protect Yourself from Sun
Skin cancer is one of most common & preventable kinds of cancer
 Nearly all skin cancer is treatable if detect early
 Avoid peak radiation hrs (10 am – 2 pm)
 Stay in the shade; Cover exposed areas
 Don’t skimp on sunscreen
 SPF30 - prevents skin reddening 30 times longer than
unprotected skin
 Apply every 2 hrs

26. 35% Cancer
deaths
linked to
diet
as reported by
Willett*
* W. C. Willett. Diet and
cancer. Oncologist.
5:393–404 (2000)

27. Recommendation 9:
Keep A Healthy Diet
The general dietary recommendations:
 Do not Over Eat (Caloric restriction /
periodic fasting)
 Rich in fruits and vegetables (Low glycemic
load), low in sugar / refined carbohydrates
 Low intake of saturated fats, cholesterol &
trans fats
 Low in red meat, processed meat, rich in
soy & fish
 Cut back on salt & MSG
 Avoid alcohol

28. Additional Recommendation :
Through Dietary Supplementation
• Improve Digestion with Probiotics & Food Enzymes
• Take Chemopreventive supplementation
Modern Approach
Through
Chemoprevention
The use of natural or synthetic
substances to reduce risk of
developing cancer

29. Cancer is a long progression disease

30. Cancer Chemoprevention Strategies
Major categories of
chemopreventive agents:
Anti-toxin
Detoxification, strengthen liver functions
Anti-infection
Strengthen immune systems
Anti-oxidant
Protect against free radical attack
Anti-cancer
Anti cell promotion
Anti cell proliferation
Activate programmed cell death
Multi-pronged approach
is recommended

31. Foods that have Cancer Preventive properties
Cancer Fighting properties Alkaline Forming
(1) properties (2)
Beans Lemons & Limes
Berries Watermelon
Cherries Grapefruit
Cruciferous Vegetables Mangoes
Chia seed / Flaxseed Papayas
Garlic Asparagus
Grapes Onions
Green Tea Parsley
Soybean Spinach
Tomatoes Broccoli
Mushrooms Garlic
Source:
1. American Institute for Cancer Research
2. Diet, Nutrition and the Healing & Prevention of Cancer & Other
Diseases (XVIII); Acid-Forming & Alkaline-Forming Food Table

32. Mushrooms (Fungus):
source of potent natural based
Chemopreventive Agents
• Mushrooms are prebiotic
• They contain Host Defence Potentiators compounds which can have immune system
enhancement properties
• They are anti tumor agents
• Currently used as adjuncts to cancer treatments in Japan, Russia, China, & U.S.A.

33. Medicinal mushrooms
Many Pharmaceuticals are derived
from the Fungus Kingdom:
• Penicillin,
• Ciclosporin, Grifola frondosa
• Griseofulvin,
Trametes versicolor
• Cephalosporin,
• Ergometrine,
• Statins
Antrodia camphorata
Pharmaceutical Properties:
• hypoglycemic,
• anti-cancer,
• anti-viral,
• immune system enhancing Ganoderma lucidum Cordyceps sinensis

34. Antrodia Camphorata: A Rare Fungus
World’s most valuable medicinal
fungus compared:
Bio-Active Ingredients Ganoderma Lucidium Antrodia Camphorata
Bio Active Triterpenes 20-50 types >200 types
Triterpenes concentration 1–3% 10-45 %
Anti-cancer Triterpenes NA 4%
AC is highly priced for its effectiveness in treating the
following ailments over centuries in Taiwan:
• Anti-cancer
• Improve liver functions
• Anti Fatigue
• Anti-inflammation
• Anti-hepatitis infection
• Improve immunity
• Anti-allergenic

35. New Anti Cancer Compound
Isolated from Antrodia Camphorata
Chemical name :
18
Antroquinonol® 19
17
16
15
22 21
14
• US Patent 7342137B1 Mar.11,2008 7 11
6 13
O 1
• US Patent 7385088B1 Jun.10,2008 5 8
9
10 12 20
23 2
• US Patent 7411003B1 Aug.12,2008 O 3
4 OH
• US Patent 7456225B1 Nov.25,2008 O
24
• US Patent 7468392B1 Dec.23,2008
• US Patent 7501454B2 Mar.10,2009 Molecular Weight: 390
Formulation: C24 H28 O4
Efficacy
Based on Human Cancer Cell, Antroquinonol® can Assist the
Treatment of Multiple Therapies in Solid Tumor.

36. Antrodia Camphorata
Powerful Natural Chemopreventive
Compound • Anti Initiation
• Anti oxidation
AC simultaneously • Anti inflammation
attack the various Anti Promotion
stages of cancer • Growth inhibition
formation Anti Progression
• Induce apoptosis
AC in Cancer Applications Summary
Treatment
Pre-Cancer therapy During Chemotherapy Post Chemotherapy
stages
Application Neo-Adjuvant /
Adjuvant Preventive
Mode: Complimentary
Anti oxidation Hepatoprotection Chemoprevention
Therapeutic
Anti infection Immune modulation Immune modulation
Actions:
Anti inflammation Tumor regression Anti oxidation

37. A Natural Health Science
Company
Establish since 2003
国际先进生物药理科技