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Global mortality landscape November 1, 2010 Christopher J.L. Murray Institute Director
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Measuring Adult Mortality Can Be Challenging
[object Object],[object Object],Levels of Adult Female Mortality Are a Key Input to Measuring Maternal Mortality
Mortality estimation at IHME ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mortality Estimation
GBD Epidemiological Regions
New Tools for Mortality Data Analysis
New Tools for Synthesizing Data Sources
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],New Tools for Synthesizing Data Sources: Methods
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Data Empirical Measurements Outliers Vital Registration 3549 77 Sample Registration Systems 53 1 Complete Birth Histories 1447 8 Summary Birth Histories 9870 685 Household Deaths 62 17 Country-Specific Surveys 10 5 Disease Surveillance Points 12 0 Murray, Laakso, Shibuya et al Original Database 1075 241 Reports and Publications 96 0 Total 16174 1034
Neonatal, Post-neonatal, Childhood Model ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Predictive Validity for Neonatal, Post-neonatal, Childhood Model Design Age Mean Relative Error Median Relative Error In Sample Neonatal 9.3% 6.2% Post-neonatal 10.9% 8.0% Child 11.4% 7.8% Dropping 20% of data Neonatal 9.8% 6.7% Post-neonatal 11.8% 8.7% Child 11.9% 8.1% Dropping 20% of countries Neonatal 11.4% 7.1% Post-neonatal 12.9% 9.1% Child 14.3% 8.9% Dropped last 10 years Neonatal 14.4% 11.4% Post-neonatal 21.0% 15.1% Child 19.2% 13.3%
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Systematic search of official, survey and published literature Rajaratnam et al, Lancet 2010
Assessing completeness of death reporting ,[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
Sibling History Data Needs to be Corrected for Survivor Bias ,[object Object],[object Object],[object Object],Obermeyer et al PLoS Medicine
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Under-5 mortality by GBD region
Global under-5 death numbers compared to other sources
Global trends in neonatal, post-neonatal and child mortality rates
Under-5 mortality rate by GBD region
Under-5 mortality rate, 2010
Annualized rate of decline in U5MR 1990-2010
Annualized percent decline in under-5 mortality by Region
Key findings ,[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adult Mortality  Global trend in adult mortality, 1970-2010
Trend in adult mortality by GBD region
Adult Mortality, 2010 Women Men
Annualized rate of decline in adult mortality, 1970-2010  Women Men
Countries with the lowest risks of adult mortality in 1970 and 2010, by sex
Key findings ,[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Model Life Table Systems ,[object Object],[object Object]
Model Life Table Systems ,[object Object]
Establishing the Standard Life Table ,[object Object],[object Object],[object Object],[object Object]
Basic mechanics ,[object Object],[object Object],[object Object]
Current Method: Establishing the standard life table ,[object Object],[object Object],[object Object],[object Object],[object Object]
Current Method: Specification of Model ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Conclusions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Global Maternal Deaths
Global Maternal Deaths Year Number of maternal deaths (Uncertainty interval) 1980 526,300 (446,400 – 629,600) 1990 441,500 (376,200 – 535,100) 2000 417,200 (365,700 – 479,200) 2008 342,900 (302,100 – 394,300)
Births by Region, 1980-2008
Global Maternal Mortality Ratio
Maternal Deaths by Region, 1980-2008
Regional trends in the MMR
Regional trends in the MMR
MMR with and without HIV
MMR per 100,000 live births, 2008
Top 21 countries: maternal deaths Order Country Deaths in 1000s (UI) Deaths (%) Cumulative % Births (%) Cumulative % 1 India 68.3 (41.6-106.2) 19.9 19.9 19.7 19.7 2 Nigeria 36.7 (22.4-57.0) 10.7 30.6 4.4 24.1 3 Pakistan 20.1 (12.3-31.3) 5.9 36.5 3.9 28.0 4 Afghanistan 20.0 (7.5-43.1) 5.8 42.3 0.9 28.9 5 Ethiopia 18.2 (11.1-28.8) 5.3 47.6 2.3 31.2 6 Congo, the Democratic Republic of the 15.4 (9.0-24.7) 4.5 52.1 2.1 33.3 7 Bangladesh 11.6 (6.7-18.7) 3.4 55.5 2.5 35.8 8 Indonesia 9.6 (5.6-16.0) 2.8 58.3 3.1 38.9 9 Tanzania, United Republic of 8.0 (4.8-12.8) 2.3 60.6 1.3 40.2 10 China 7.3 (6.4-8.3) 2.1 62.7 13.3 53.5 11 Malawi 6.8 (4.0-10.9) 2.0 64.7 0.4 53.9 12 Côte d'Ivoire 6.8 (4.1-10.8) 2.0 66.7 0.5 54.4 13 Kenya 6.2 (3.6-10.2) 1.8 68.5 1.1 55.5 14 Chad 5.3 (3.3-8.2) 1.5 70.0 0.4 55.9 15 Mozambique 5.2 (3.1-8.4) 1.5 71.5 0.6 56.5 16 Uganda 5.2 (3.1-8.2) 1.5 73.0 1.1 57.6 17 Cameroon 5.0 (2.8-8.1) 1.4 74.4 0.5 58.1 18 Niger 4.7 (3.0-7.3) 1.4 75.8 0.6 58.7 19 Angola 4.6 (1.8-9.9) 1.3 77.1 0.6 59.3 20 Sudan 4.0 (2.5-6.0) 1.2 78.3 0.9 60.2 21 Mali 3.6 (2.3-5.5) 1.1 79.4 0.4 60.6 All other countries (160) 70.3 (43.0-112.2) 20.5 100.0 39.3 100.0 Total   342.9 100.0 100.0 100.0 100.0
Annualized Rate of Decline in MMR,  1990 to 2008
Annualized Rate of Decline in MMR, excluding HIV, 1990 to 2008
Gaining Ground ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Progress Undocumented But Not Unexpected ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adverse Impact of HIV ,[object Object],[object Object],[object Object],[object Object]

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maternal mortality sri lanka global mortality landscape_murray_110110_ihme

  • 1. Global mortality landscape November 1, 2010 Christopher J.L. Murray Institute Director
  • 2.
  • 3.
  • 4.
  • 5.
  • 8. New Tools for Mortality Data Analysis
  • 9. New Tools for Synthesizing Data Sources
  • 10.
  • 11.
  • 12. Data Empirical Measurements Outliers Vital Registration 3549 77 Sample Registration Systems 53 1 Complete Birth Histories 1447 8 Summary Birth Histories 9870 685 Household Deaths 62 17 Country-Specific Surveys 10 5 Disease Surveillance Points 12 0 Murray, Laakso, Shibuya et al Original Database 1075 241 Reports and Publications 96 0 Total 16174 1034
  • 13.
  • 14. Predictive Validity for Neonatal, Post-neonatal, Childhood Model Design Age Mean Relative Error Median Relative Error In Sample Neonatal 9.3% 6.2% Post-neonatal 10.9% 8.0% Child 11.4% 7.8% Dropping 20% of data Neonatal 9.8% 6.7% Post-neonatal 11.8% 8.7% Child 11.9% 8.1% Dropping 20% of countries Neonatal 11.4% 7.1% Post-neonatal 12.9% 9.1% Child 14.3% 8.9% Dropped last 10 years Neonatal 14.4% 11.4% Post-neonatal 21.0% 15.1% Child 19.2% 13.3%
  • 15.
  • 16. Systematic search of official, survey and published literature Rajaratnam et al, Lancet 2010
  • 17.
  • 18.  
  • 19.  
  • 20.  
  • 21.  
  • 22.  
  • 23.  
  • 24.  
  • 25.  
  • 26.
  • 27.
  • 28. Under-5 mortality by GBD region
  • 29. Global under-5 death numbers compared to other sources
  • 30. Global trends in neonatal, post-neonatal and child mortality rates
  • 31. Under-5 mortality rate by GBD region
  • 33. Annualized rate of decline in U5MR 1990-2010
  • 34. Annualized percent decline in under-5 mortality by Region
  • 35.
  • 36.
  • 37. Adult Mortality Global trend in adult mortality, 1970-2010
  • 38. Trend in adult mortality by GBD region
  • 40. Annualized rate of decline in adult mortality, 1970-2010 Women Men
  • 41. Countries with the lowest risks of adult mortality in 1970 and 2010, by sex
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.
  • 47.
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
  • 53.
  • 54.
  • 55.
  • 56.
  • 57.
  • 58.
  • 59.
  • 60.
  • 61.
  • 62.
  • 63.
  • 64.
  • 65.
  • 67. Global Maternal Deaths Year Number of maternal deaths (Uncertainty interval) 1980 526,300 (446,400 – 629,600) 1990 441,500 (376,200 – 535,100) 2000 417,200 (365,700 – 479,200) 2008 342,900 (302,100 – 394,300)
  • 68. Births by Region, 1980-2008
  • 70. Maternal Deaths by Region, 1980-2008
  • 73. MMR with and without HIV
  • 74. MMR per 100,000 live births, 2008
  • 75. Top 21 countries: maternal deaths Order Country Deaths in 1000s (UI) Deaths (%) Cumulative % Births (%) Cumulative % 1 India 68.3 (41.6-106.2) 19.9 19.9 19.7 19.7 2 Nigeria 36.7 (22.4-57.0) 10.7 30.6 4.4 24.1 3 Pakistan 20.1 (12.3-31.3) 5.9 36.5 3.9 28.0 4 Afghanistan 20.0 (7.5-43.1) 5.8 42.3 0.9 28.9 5 Ethiopia 18.2 (11.1-28.8) 5.3 47.6 2.3 31.2 6 Congo, the Democratic Republic of the 15.4 (9.0-24.7) 4.5 52.1 2.1 33.3 7 Bangladesh 11.6 (6.7-18.7) 3.4 55.5 2.5 35.8 8 Indonesia 9.6 (5.6-16.0) 2.8 58.3 3.1 38.9 9 Tanzania, United Republic of 8.0 (4.8-12.8) 2.3 60.6 1.3 40.2 10 China 7.3 (6.4-8.3) 2.1 62.7 13.3 53.5 11 Malawi 6.8 (4.0-10.9) 2.0 64.7 0.4 53.9 12 Côte d'Ivoire 6.8 (4.1-10.8) 2.0 66.7 0.5 54.4 13 Kenya 6.2 (3.6-10.2) 1.8 68.5 1.1 55.5 14 Chad 5.3 (3.3-8.2) 1.5 70.0 0.4 55.9 15 Mozambique 5.2 (3.1-8.4) 1.5 71.5 0.6 56.5 16 Uganda 5.2 (3.1-8.2) 1.5 73.0 1.1 57.6 17 Cameroon 5.0 (2.8-8.1) 1.4 74.4 0.5 58.1 18 Niger 4.7 (3.0-7.3) 1.4 75.8 0.6 58.7 19 Angola 4.6 (1.8-9.9) 1.3 77.1 0.6 59.3 20 Sudan 4.0 (2.5-6.0) 1.2 78.3 0.9 60.2 21 Mali 3.6 (2.3-5.5) 1.1 79.4 0.4 60.6 All other countries (160) 70.3 (43.0-112.2) 20.5 100.0 39.3 100.0 Total   342.9 100.0 100.0 100.0 100.0
  • 76. Annualized Rate of Decline in MMR, 1990 to 2008
  • 77. Annualized Rate of Decline in MMR, excluding HIV, 1990 to 2008
  • 78.
  • 79.
  • 80.

Notes de l'éditeur

  1. Mention predictive validity testing
  2. Mention predictive validity testing
  3. DATA ARRANGED BY CHILD/ADULT
  4. The mortality work group successfully published three methods papers in PLoS Medicine in April 2010, exceeding the plans delineated for FY10. The first, Measuring Under-Five Mortality: Validation of New Lost-Cost Methods , describes significantly improved methods for estimating under-five mortality using summary birth histories. It introduces a new model which enables more accurate and timely estimates for child mortality in systems without complete vital registration data, and complete birth history data. This model will also provide more accurate sub-national child mortality estimates when applied to country census data.   The second article, What Can We Conclude from Death Registration? Improved Methods for Evaluating Completeness , systematically evaluates the many variants of the standard death distribution methods used to assess completeness of vital registration systems. It presents three variants of the death distribution methods that perform the best in most situations. This newly developed model has been put to use in generating the adult mortality estimates mentioned above. The third paper, Measuring Adult Mortality Using Sibling Survival: A New Analytical Method and New Results for 44 Countries, 1974-2006, presents a new method which improves estimation of mortality rates directly from empirical data sources for many countries. The model produces much more plausible estimates of adult mortality and will be highly applicable to all large nationally representative survey programs.
  5. Mention predictive validity testing
  6. 545 surveys with summary birth history microdata or tabulated data 256 surveys with complete birth history microdata DDM on household deaths
  7. Logit transformation