Overview of policy and financial issues negatively impacting biotechnology innovation; presentation calls for a stakeholder approach to new biotechnology business models.

1. BIOMEDevice Conference, 2009 Boston, Ma Evolution in the making: emergence of new life science business models.

2. Fitness landscape and selection pressure Fitness landscape - current conditions under which a species thrives, having been best “outfitted” for survival in the environment Selection pressure – imposition of new conditions on a species within an ecosystem  Forces those species with attributes best suited to survive under new conditions

3. Global fitness landscape Specialty and emerging clusters are becoming increasingly attractive as pharma and biotech companies strive to reduce costs and increase flexibility Established “Specialty Clusters” Cluster Size Large Emerging Cluster Capability Small World-class SF MA SD Singapore India China United Kingdom Ireland Switzerland Philadelphia RTP Canada Madison DC / Baltimore Integrated Clusters Emerging Clusters Leading Integrated Clusters Lagging Integrated Clusters

6. Selection pressures-changing conditions Policy Financing Market Uncertainty Innovation Commercialization

9. On the biotech side- what does the environment look like

10. On the biotech side- what does the environment look like

11. On the device side- what does the environment look like

16. Integrate stakeholders and shareholders to sustain life science companies

17. Swimming to the next island of financing…