Effectiveness of vacuum assisted closure versus Surgical Debridement.pptx
CAWC 2013_Poster
1. PURPOSE
Wound healing is a complex
process that consists of
inflammatory, proliferative, and
remodelling phases. Disruption of
this wound healing process, such
as that seen in diabetic patients,
often leads to non-healing wounds
or ulcers. As a result, it is
imperative to treat these wounds
with innovative wound dressings
that can facilitate healing by
optimizing the wound
microenvironment.
The purpose of this study was to
evaluate the healing rate of patients
with diabetic foot ulcerations
treated with Collagen/ORC, a novel
wound treatment modality designed
to contribute to the wound matrix
with collagen and reduce the
activity of wound proteases by
binding cellulose to their receptor
sites.
Collagen/ORC promotes healing process in diabetic patients
with chronic ulcers
Ivana Roth-Albin B.Sc., M.Sc., CCRA, Emily Bertrand, P.V. Mayer MB, BCh, CCFP
The Mayer Institute, Hamilton, Ontario, Canada
CAWC 2013, Vancouver, BC
METHODS
Chronic wounds were defined as
those that showed less than 30%
reduction in size over the previous
12 weeks. Wound patients received
the Collagen/ORC treatment every
2-3 days for up to 12 weeks. Every
2 weeks, photographs of ulcers
were taken, ulcer measurements
were recorded and surface area
was calculated. Wound healing
status was calculated based on
wound area reduction. Healing was
defined as complete
epithelialization.
RESULTS CONCLUSION
Ten patients were analyzed in this
study. After 2 weeks of treatment,
there was an average reduction in
wound size of 65%. By week 8,
complete healing was seen in 9 of the
10 patients.
The results showed that
Collagen/ORC kick started wound
healing in patients with previously
stalled diabetic wounds.
References
Morgan C, Nigam Y. Naturally derived
factors and their role in the promotion of
angiogenesis for the healing of chronic
wounds. Angiogenesis 2013; 16(3):493-
502
Holmes C, Wrobel JS, MacEachern MP,
Boles BR. Collagen-based wound
dressings for the treatment of diabetes-
related foot ulcers: a systematic review.
Diabetes, Metabolic Syndrome and
Obesity: Targets and Therapy 2013; 6:17-
29
Brem H, Balledux J, Bloom T, Kerstein MD,
Hollier L. Healing of diabetic foot ulcers and
pressure ulcers with human skin
equivalent: a new paradigm in wound
healing. Archives of Surgery 2000;
135(6):627-634
Patient 1 Patient 2
Patient 4Patient 3
After 6 weeks of
Collagen/ORC treatment,
wound healed.
A 96 year old patient with a 4 year history of diabetes presented with a
Grade A1+ ulcer on the dorsum aspect of the right foot measuring 0.8
cm2. The ulcer had been present for 4 weeks and was full of devitalised
tissue. The wound was surgically debrided and the ulcer site was
dressed as per treatment plan with Collagen/ORC.
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
0 2 4 6
WoundSurfaceArea(cm2)
Time from initial treatment (weeks)
Reduction of Wound Surface Area
0
0.5
1
1.5
2
2.5
3
3.5
4
0 2 4 6 8
WoundSurfaceArea(cm2)
Time from initial treatment (weeks)
Reduction of Wound Surface Area
A 63 year old patient with a 12 year history of diabetes presented with a
Grade A2 ulcer on the right medial aspect of the heel measuring 3.8 cm2.
The ulcer had been present for 7 months and was full of devitalised
tissue. The wound was surgically debrided and the ulcer site was
dressed as per treatment plan with Collagen/ORC. After 8 weeks of
Collagen/ORC treatment, wound healed.
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0.45
0 2 4 6 8
WoundSurfaceArea(cm2)
Time from initial treatment (weeks)
Reduction of Wound Surface Area
Week 4 Week 6
Week 0 Week 2
Week 0 Week 2
Week 6Week 4 Week 4 Week 6
Week 8
Week 0 Week 2 Week 8
Week 6Week 4
A 46 year old patient with a 17 year history of diabetes presented with a
Grade A1+ ulcer on the right 4th digit amputation site measuring 0.4 cm2.
The ulcer had been present for 7 months and was full of devitalised
tissue. The wound was surgically debrided and the ulcer site was
dressed as per treatment plan with Collagen/ORC. After 8 weeks of
Collagen/ORC treatment, wound healed.
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
0 2 4 6 8 10
WoundSurfaceArea(cm2)
Time from initial treatment (weeks)
Reduction of Wound Surface Area
A 63 year old patient with a 17 year history of diabetes presented with a
Grade A1+ ulcer on the dorsum aspect of the right foot measuring 1.4
cm2. The ulcer had been present for 10 weeks and was full of devitalised
tissue. The wound was surgically debrided and the ulcer site was
dressed as per treatment plan with Collagen/ORC. The wound surface
area showed a 83 % reduction in 10 weeks.