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- 1. Anti-Aging LifePak ® This material has been prepared by Pharmanex to be used in conjunction with general educational events and activities only. Alterations or modifications of this presentation without the express approval of Pharmanex are prohibited.
- 5. 1. Nutrient Deficiencies Source: USDA 1994-96 CSFII
- 14. Background Information Cell Old Cell Days to Months Cell Division New Cells Programmed Cell Death (Apoptosis) Old Cell
- 15. Nucleus Cell DNA G T C A Mitochondria
- 20. Summary: How Do We Age? Body Cell Weak Antioxidant Defense DNA Damage Free Radical Production DNA Damage Impaired Cellular Function and Cell Regeneration Impaired Energy Production Aging Symptoms Mitochondria Cell Nucleus
- 24. LifePak ® & DNA Damage
- 26. Green Tea and Longevity
- 28. Green Tea and Longevity Green Tea Consumption (Cups/Day) Prospective, 11-year cohort study of 8,552 subjects in Yoshimi, Japan, 1986-1997. From: H. Fujiki et al., Ann. N.Y.Acad.Sci., 928:274, 2001; used with author’s permission.
- 31. LifePak ® addresses the root causes of aging symptoms at the molecular level: DNA damage in cells and mitochondria* 6. Aging Symptoms *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- 45. Copyright 2002 by Pharmanex LLC The copyright owner grants permission to Pharmanex employees, distributors, and other representatives to use this presentation IN ITS ENTIRETY for educational purposes only. It cannot be changed or modified in any way without prior written permission of the copyright owner.
Notes de l'éditeur
- This is a technical presentation that explains what LifePak is, what it can do for your health, and why LifePak is so unique. [next] Instructions: This presentation contains some animated slides. In PowerPoint, you can advance animations and slides several ways: by pressing the space bar, arrow-down button, page-down button, or enter button by clicking the mouse Whenever you see [next] in the speaker notes, please use one of the above means to advance either the slide or an animation on the same slide.
- Just what exactly is LifePak? “ A comprehensive supplementation program for a long and healthy life.” LifePak is unique, because it is a complete program, that provides optimum supplementation. Let’s take a closer look at what optimum supplementation means. [next]
- Optimum Supplementation means that all nutrients are provided in the optimal amounts necessary to stay dynamically healthy long-term. Now, dynamic health is not just about the absence of illness or the absence of a headache. Instead, it’s about waking up in the morning and feeling so good and so energetic that you feel like you can handle anything that comes your way. Health that is so robust that not only do you not become sick, but you become a different individual. In order to feel this way, you need more than minimum daily requirements. Rather, optimum levels of nutrients need to be part of your daily program. [next] First, optimum supplementation makes sure that you meet all nutrient recommendations, known as the Recommended Dietary Allowances (RDAs). [next] Optimum supplementation also considers our typical dietary intakes: For example, most people living in this country already get enough phosphorus from their diets, and too much phosphorus is not good. Yet, most multivitamins on the market have phosphorus in it. LifePak doesn’t. [next] For some nutrients, especially vitamins C and E, the optimum levels for long term health are much higher than the RDAs. Many clinical studies have shown this. So rather than just sticking with the RDAs, optimum supplementation uses those higher levels whenever there is sound scientific consensus to do so. [next] Optimum supplementation also provides the so-called semi-essential nutrients that have been shown to be necessary for optimal health. They do not have an RDA, but they occur in healthy foods and have profound health benefits. The phytonutrients and alpha-lipoic acid fall in this category. [next] Typical multivitamins do not do any of this. LifePak does. Next, let’s look at LifePak’s major health benefits… [next]
- LifePak provides optimum supplementation for everybody and has six major health benefits. [next] If you think about it, the loss of any one of these health benefits can significantly affect your quality of life in a negative way. And LifePak contributes to all of them: It addresses all possible nutrient deficiencies It has cardiovascular benefits and provides complete bone nutrition* It promotes healthy immune function, supports normal healthy blood sugar metabolism* It protects against the symptoms of aging* Let’s look at each of these benefits, and we’ll spend a little more time on the anti-aging benefits. [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- First, let’s spend a minute on nutrient deficiencies. Research clearly shows that virtually all of us don’t get the recommended amounts of vitamins and minerals from our diets. For example, recent surveys by the U.S. government show that more than half the people don’t get enough vitamin A, vitamin E, and vitamin B6, and that two out of three people need more calcium, magnesium, and zinc. Now, when you go and buy a typical multivitamin/mineral product, you assume that it should take care of any possible nutrient deficiencies you may have, right? Not so! For two reasons: 1. Popular multivitamins are low in some nutrients you need most, for example calcium and magnesium. 2. Popular multivitamins often use inexpensive nutrient forms that are poorly absorbed by the body to save costs. Now, when you supplement with LifePak, watch what happens to this graph… [next]
- … you will not be deficient in any nutrient. People using LifePak will meet the RDAs of all nutrients. LifePak contains the right amounts of high-quality, easily absorbed nutrients so you can rely on it to make a difference in correcting and preventing any and all nutrient deficiencies you may have. When you use these kinds of quality ingredients in the right amounts, there is no way to fit them into a once-a-day capsule or tablet; and this is precisely why LifePak contains multiple capsules. [next]
- Now, let’s talk about the cardiovascular benefits. [next] LifePak provides the optimum amounts of over 20 different antioxidant nutrients that work together in the body to protect the LDL blood lipids from oxidation by free radicals.* You probably know that LDL-cholesterol is the bad cholesterol you want to keep low. But what’s even worse is when this LDL-cholesterol becomes oxidized in the body. When it is oxidized it tends to stick much more to the inner artery walls. [next] LifePak is clinically proven to make LDL particles more resistant against oxidation by free radicals. This is shown on this graph. LifePak makes the LDLs less sticky, and that’s a huge cardiovascular health benefit!* [next] This is one of the silent benefits of LifePak. You may not feel this LDL protection at first, but within days profound changes take place inside your body which you will come to appreciate years later. [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Aside from LDL protection, LifePak has many other cardiovascular benefits: [next] It helps maintain normal blood pressure and heart function with calcium and magnesium.* [next] It also provides the right B vitamins that are critical in helping to maintain low blood levels of homocysteine.* The medical community used to think that cholesterol was the major dynamic in healthy arteries, but they have discovered that maintaining low homocysteine levels is also an extremely significant factor in healthy arteries. [next] And finally, LifePak supports good circulation throughout the body due to its high levels of well-researched flavonoid phytonutrients. As you can see, LifePak is a powerful cardiovascular formula.* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- When it comes to bone nutrition, LifePak is hard to beat. [next] Most people know that calcium is important for healthy bones, and that getting enough calcium from the diet can help maintain strong bones as we age.* LifePak contains much more calcium than typical multivitamins to make sure that virtually everybody taking it will meet the optimum calcium recommendations by the major health authorities. But calcium alone is not enough. You need to have ALL other bone nutrients as well. [next] Magnesium, is the other major bone mineral, and like calcium, it has many clinical studies that show bone benefits. Insufficient magnesium intake is one of the most wide-spread nutrition problems in developed countries. Three out of four people don’t get enough magnesium in the United States. [next] LifePak contains vitamins D [next] and K, [next] boron and [next] silicon, which help regulate bone metabolism, and [next] phytoestrogens from soybeans, which promote the incorporation of minerals into the bone.* [next] Importantly, LifePak does NOT contain any phosphorus, because we all get too much phosphorus from our diets anyway, and excess phosphorus actually interferes with bone mineral metabolism. Many other multivitamins do contain phosphorus, because they use calcium phosphate as a cheap and poorly absorbed calcium source. [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- LifePak provides targeted supplementation with the most important nutrients for our immune system:* [next] vitamins C and E, the carotenoids, as well as vitamins A and B6 and zinc. [next] Remember this graph? [next] Incidentally, these immune nutrients are exactly those nutrients that people lack most in their daily diets, as we can see on this graph. [next] Now, it’s important to note that LifePak provides long-term immune support just by correcting these immune nutrient deficiencies, while Immune Formula from Pharmanex gives you the extra boost for a shorter duration when you need it most.* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- LifePak is also very beneficial in maintaining normal blood sugar levels already within the healthy range and normal insulin function.* [next] Most importantly, LifePak provides highly bioavailable chromium, which is essential for normal insulin function. A number of studies show that many people do not get enough chromium from their diets, and that supplementation of chromium has profound health benefits.* [next] A number of other nutrients in LifePak are also important in normal healthy blood sugar metabolism. [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Now let’s turn to the anti-aging benefits of LifePak. [next] It’s really important for you to understand that LifePak addresses the root cause of aging, [next] which is DNA damage.* [next] DNA stands for deoxyribonucleic acid. DNA stores all your genetic information. [next] It is present in just about every body cell, and it is the blueprint from which all new cells are created and old ones regenerated. So, since it is stored in the cell, let’s start by taking a closer look at the cell…. [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Our bodies are made of millions of cells, like this one here. Each cell has a very limited life span. [next] Some only live a few days, while others last many months. The reason we don’t die after a few days or months is because the cells regenerate themselves constantly. [next] They do this by cell division, as you can see here. [next] Now you have two renewed cells, which age again [next] and keep regenerating themselves through cell division again and again. This process also gives the body a chance to eliminate damaged cells [next] by a process called “programmed cell death” or “apoptosis.” This is important for regulating growth and overall health. This is how we get to live so long. [next]
- Now, let’s look at a cell a little closer. Each and every one of our cells has a nucleus. [next] Cells also have many little structures called mitochondria , [next] and here is an enlarged picture of one of them. Now, the nucleus and the mitochondria are the only places of a cell [next] where you find DNA. Most of our DNA is in the nucleus DNA is essential for all cellular functions, including how the cell works, and how it divides and regenerates itself. Like a CD ROM, DNA stores all information. If the DNA is damaged, the cell’s function can be impaired, or it can not regenerate itself properly by cell division. [next]
- Now, let’s look at how DNA gets damaged. Most often, DNA is damaged by free radicals. Free radicals are highly reactive compounds that are ubiquitous in the body and in our environment. [next] This is a DNA molecule that’s being attacked by two free radicals… [next] …literally breaking the DNA into pieces. How does the body prevent this free radical damage? [next] It prevents DNA damage with antioxidants, which are compounds that can catch or neutralize free radicals before they can hurt us. [next]
- Now, here is a scary fact: [next] Every day, the DNA in a single body cell gets damaged 73,000 times! [next] Fortunately, our cells have DNA repair enzymes that fix most of this damage. So aging depends on a delicate balance of DNA damage and repair. Unfortunately, as we age this balance seems to shift in favor of DNA damage because our antioxidant defense system becomes less efficient. [next]
- Now, let’s look at the mitochondria more closely. These are the powerhouses or batteries that generate energy for the cell. They burn the food calories with oxygen to form energy that can be used by the cell in the form of ATP. [next] They have been called the “perpetrators of aging” because about two to five percent of the oxygen they use is converted into free radicals. This is a normal process that’s always going on as long as you breathe. There is little you can do about it. Anytime you convert food energy and oxygen into usable cellular energy, this happens. Now, because of this, the mitochondria suffer 16 times more DNA damage than nuclear DNA and, what’s more, the mitochondria have no repair enzymes. So they depend entirely on their antioxidant defense system for DNA protection! Many researchers agree that mitochondrial DNA damage is perhaps the most important contributor in the aging process overall. For example, when scientists knocked out the antioxidant defense of mouse mitochondria, the animals only lived a week compared to their normal two-year life span! It’s also interesting to note that a cell from a young mammal has about a 1,000 mitochondria, while you only find about a 100 in cells of an aged mammal. Researchers believe that the impairment in mitochondrial function is related to the progressive loss of energy we experience as we age. [next]
- [optional slide, currently blocked, self-animated] You can see here the many places where free radicals are produced in the mitochondria… [next]
- Now, let’s summarize how we age: [next] Here is a typical body cell… [next] …which has a nucleus and mitochondria, both containing DNA. [next] As we age, our antioxidant defense system becomes weaker, leading to more free radical damage to DNA, which causes... [next] …impaired cellular function and regeneration. At the same time, [next] the large amounts of free radicals produced in the mitochondria damage mitochondrial DNA… [next] …which leads to impaired energy production, which also impairs cellular function and regeneration. [next] These are the two major ways which lead to the appearance of aging symptoms. [next]
- Here is a list of things that can cause DNA damage: [next] First, free radicals from your mitochondria, as we have seen. [next] Then, free radicals form environmental pollution, such as ozone gas. (Did you know that copy machines in the office generate ozone?) [next] Exposure to UV light, X-rays, and cosmic radiation can cause DNA damage, and… [next] …those of you who still smoke should know that each cigarette releases 10 quadrillion free radicals into your lungs! This is the main reason why smokers age so much faster than non-smokers. [next]
- So, what can you do to reduce your DNA damage? There are really only two ways to protect your DNA: [next] First, you can reduce your exposure to free radicals by not smoking and by avoiding excessive sunlight exposure and polluted environments. [next] At the same time, you can improve your antioxidant defense system by eating more fruits and vegetables, and by supplementing your diet with LifePak.* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- We’ve talked about LifePak providing DNA protection. Now let’s look at the arsenal of nutrients LifePak provides to fight DNA damage, protect DNA, and enhance DNA repair.* *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- These ingredients are all found in LifePak and are all found in the correct dosage that your body needs. For example, the antioxidant vitamins C and E have been clinically proven to reduce DNA damage and promote DNA repair.* The three B vitamins, B6, folic acid, and B12, are absolutely essential for normal DNA synthesis, replication and repair.* Most of us in developed countries. don’t get enough of these particular B vitamins in our diets, causing all sorts of health problems. Zinc is well known to stabilize and protect the DNA molecules, and again, dietary zinc intakes tend to be way too low in our society.* And the list goes on... [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Here are more of the ingredients found in LifePak. Are you beginning to see why we can call LifePak a comprehensive nutritional wellness program? The comprehensive carotenoid blend in LifePak is unique because it’s balanced and very high in lycopene. Lycopene is the red color in tomatoes and watermelons. It has been the most clinically studied ingredient shown to reduce DNA damage and help cell protection.* LifePak provides the same amounts of flavonoids as diets recommended by the National Cancer Institute, with 5 to 10 servings of fruits and vegetables. In line with the Pharmanex 6S Quality Process ™ , LifePak only contains clinically proven, standardized flavonoid extracts. These flavonoids offer significant DNA protection.* The most powerful flavonoids come from green tea [next]. *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Here is a happy old guy! He knows something that Western science is just discovering - the importance of green tea to longevity.
- Here is a little background information on tea. [next] Green tea has not been fermented. The leaves are just dried and cut. Oolong tea is partially fermented, and black tea is extensively fermented. That’s important to know because during the fermentation process the chemistry of tea is changed. [next] Green tea contains the highest amount of catechins. These catechins are lost during fermentation. Green tea has five major catechin compounds which are abbreviated by these letters: C, EC, ECG, EGC, and EGCG. These green tea catechins are among the most powerful compounds for cell and DNA protection known to humankind.* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Here are the results from a huge study done in Japan with 8,552 subjects. This chart shows the relationship between the number of cups of tea consumed per day and the mean age of death in men and women. As you can see, there is a strong relationship between how much tea is consumed and longevity. Those people who drank the most green tea lived an average of four to six years longer than those who consumed the least. These and many other studies substantiate the value of green tea catechins for longevity. [next]
- Perhaps the most important anti-aging nutrient is alpha-lipoic acid. [next]
- This is the star among the anti-aging antioxidants! [next] This amazing antioxidant is also known as the “universal antioxidant” because it augments the body’s entire antioxidant network, and therefore has the ability to neutralize many different free radicals. It protects the nervous system because it can cross the blood-brain barrier. Because alpha-lipoic acid directly and indirectly reduces DNA damage, it is the best mitochondrial antioxidant overall. [next] LifePak provides 30 to 50 mg of alpha lipoic acid (30 mg in Regular and Women, 50 mg in Prime), which are the amounts recommended by Professor Lester Packer, who is a world expert in antioxidant and aging research.
- In summary, [next] LifePak is different and better than most anti-aging supplements because it addresses the root causes of the aging process at the molecular level, [next] which is DNA damage that occurs in our cells and mitochondria.* [next] *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- This slide summarizes again the major health benefits of LifePak. Can you see how a LifePak program is truly a comprehensive wellness program and what we mean by optimum supplementation? [next]
- We offer three versions of LifePak. First, there is regular LifePak which is designed to be used by any adult. This formula is especially appropriate for young men due to its low iron content. [next]
- LifePak Women is designed for the special nutritional needs of young, pre-menopausal women. [next]
- LifePak Women [next] offers all of the benefits of regular LifePak, plus [next] extra bone nutrition* [next] more iron for blood formation and energy* [next] added nutrients to help maintain female hormonal balance* [next] and cranberry to promote normal urinary tract health* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- LifePak Prime is intended for post-menopausal women and men over the age of 40. [next]
- LifePak Prime [next] provides all of the benefits of regular LifePak, plus [next] extra bone nutrition similar to LifePak Women* [next] extra anti-aging nutrient and antioxidants, especially with added alpha-lipoic acid, coenzyme Q10, and gluathione* [next] LifePak Prime also delivers glucosamine, a building block for health joint cartilage* [next] BioGinkgo to help maintain healthy brain circulation and memory function* [next] and extra zinc and vitamin B12 for immune function* [next] *These statements have not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- There are four more products in the LifePak family. Please note that we completely reformulated Jungamals, which is LifePak for Kids. Among the many improvements, we greatly boosted its bone and immune benefits.* [next] *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- A few words about safety. [next] All of the vitamin and mineral levels in LifePak are at or below the NOAEL which stands for No Observed Adverse Effects Level, that were established by the Council for Responsible Nutrition in 1998. [next] The phytonutrients are all added in safe amounts that can also be obtained when eating very healthy diets rich in fruits and vegetables. [next] And we are the only company that can say we have two double-blind clinical studies showing no adverse effects whatsoever for LifePak. [next]
- LifePak [next] is to be taken twice daily with meals because [next] meals enhance the absorption of many LifePak nutrients, and improve the tolerance to the product. [next] Twice-daily delivery promotes a more steady nutrient delivery throughout the day, as can be seen here in this example of vitamin B6. This is the blood level of vitamin B6 in a person who took two LifePak packets with breakfast. You can see a large increase followed by a long period where the body’s cells see little of the vitamin B6. The blue line is from a person who took LifePak as directed with breakfast and dinner. You can see the difference.
- In a survey of over 200 LifePak users, 91% felt that LifePak works well or extremely well.
- That’s because they can tell it makes a difference.
- How does it make a difference? People feel an increase in energy, they notice their immune system is healthier, and they have better sleeping habits*. *This statement has not been evaluated the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
- Tens of thousands of clinical studies have been done on nutritional ingredients; on how they interact with each other and on their benefits to the human body. Now, 60 Pharmanex scientists have partnered with over 100 scientists from top universities around the world to take advantage of these studies. They have researched, tested, formulated, and crafted this accumulated wisdom, presenting it to you in a masterpiece program called LifePak. Thanks to two small packets a day, a comprehensive wellness program is available that gives you exactly what you need for a long, healthy, and productive life.