Supporting the implementation of LPMS for the good of research information... A National Perspective

1. Supporting research to make patients, and the NHS, better
Supporting the implementation of LPMS for the
good of research information...
A National Perspective
Richard Corbridge, CIO

2. …for the good of research
information...
“As part of the National Institute for Health Research, we ensure that
the NHS can provide the infrastructure that allows high-quality clinical
research to take place within the NHS, so that patients can benefit from
new and better treatments”
Our key roles are:
To enable the provision of research
To performance manage where provision has been provided
To provide information about research capability
To facilitate the sharing of best practice for delivery

3. The HLOs: Target Summary

4. The HLO Family

5. Measure:
Number
of
par,cipants
recruited
in
a
repor,ng
quarter
into
NIHR
CRN
Por:olio
studies
Calcula,on:
Recruitment
(both
commercial
and
non-­‐
commercial)
by
quarter,
mapped
to
an
English
site
100,398
174,820
149,196
112,233
125,410 159,963
126,949
124,668
152,583114,558
139,800
133,798
0
100,000
200,000
300,000
400,000
500,000
600,000
700,000
2009/10 2010/11 2011/12
Participants
Q1 Q2 Q3 Q4 Financial Year Target

6. Measure:
HLO
2:
Propor,on
of
contract
studies
achieving
or
surpassing
their
recruitment
target
during
their
planned
recruitment
period,
at
confirmed
Network
sites
Calcula,on:
Part
1:
(Actual
Closure
Date-­‐Actual
Opening
Date)/(Planned
Closure
Date
-­‐
Actual
Opening
Date)
Part
2:
(Recruitment
total
at
network
sites
/
Planned
Network
Sample
Size)
Studies
have
to
meet
Part
1
&
Part
2
to
count
toward
objec,ve.
Therefore
≤
100%
to
,me
AND
≥
100%
to
target
Closed
studies
only:
Actual
Closure
Date
will
determine
repor,ng
period
Por:olio
Entry
Date
&
Actual
Opening
Date
(from
April
1st
2010)
will
determine
which
studies
are
included
1
4 5
6
15
14
19
54
0
1
7
11 19
13
13
25
16 67
0%
50%
100%
Q1 Q2 Q3 Q4 Annual
Total
Q1 Q2 Q3 Q4 Annual
Total
2010/11 2011/12PercentageofStudies
Studies failing to achieve their recruitment target during their planned
recruitment period
Studies achieving or surpassing their recruitment target during their planned
recruitment period

7. Measure:
Number
of
commercial
contract
studies
on
the
NIHR
CRN
Por:olio
as
a
percentage
of
the
total
commercial
MHRA
CTA
approvals
for
Phase
II–IV
studies,
on
an
annual
basis
Calcula,on:
No.
of
studies
adopted
on
to
the
CRN
Por:olio
No.
of
Industry
studies
approved
by
MHRA
per
financial
year
63
55
71 74
263 71
84
60
98
313
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Q1 Q2 Q3 Q4 Annual
Total
Q1 Q2 Q3 Q4 Annual
Total
2010/11 2011/12
PercentageofStudies
% NIHR CRN adopted studies as a proportion of MHRA CTA
approvals
Interim Target
Final Target

8. Measure:
Propor,on
of
studies
obtaining
NHS
permission
within
40
calendar
days
(from
receipt
of
a
valid
complete
applica,on)
9 12
19
14 54
37
60
47 69 213
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
Q1 Q2 Q3 Q4 Annual
Total
Q1 Q2 Q3 Q4 Annual
Total
2010/11 2011/12
PercentageofStudies
% Studies Achieving NHS Permission Within 40 Days
Interim Target
Final Target

9. Measure:
HLO
5:
Propor,on
of
contract
studies
achieving
first
par,cipant
recruited
within
30
calendar
days
of
NHS
Permission
being
issued
or
First
Network
Site
Ini,a,on
Visit,
at
confirmed
Network
sites
Calcula,on:
Date
of
First
Network
Par,cipant
First
Visit
(
FNPFV)
-­‐
(Date
of
first
NHS
Permission
at
network
site
OR
First
Network
Site
Ini,a,on
Visit,
whichever
is
later)
3 9
12
8
32
29
20
25
30
104
4
7
5
16
8
12
9
3
32
1 5
8
14 8 9 10 8 35
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
Q1 Q2 Q3 Q4 Annual
Total
Q1 Q2 Q3 Q4 Annual
Total
2010/11 2011/12
PercentageofStudies
30 Days or Less Between 31 and 60 Days
More than 60 Days Interim Target
Final Target

10. Measure:
HLO
6:
Propor,on
of
NHS
Trusts
recrui,ng
each
year
into
NIHR
CRN
Por:olio
studies
Calcula,on:
The
propor,on
of
trusts
on
the
CCRN
team's
list
of
member
organisa,ons
that
are
repor,ng
recruitment
at
any
point
in
the
previous
rolling
year.
For
example
the
metric
in
Q3
2011/12
will
examine
whether
there
has
been
recruitment
a]ributed
to
that
trust
at
any
point
in
Q4
2010/11,
Q1
2011/12,
Q2
2011/12
or
Q3
2011/12.
90%
91%
92%
93%
94%
95%
96%
97%
98%
99%
100%
Q1 Q2 Q3 Q4 Annual
Total
Q1 Q2 Q3 Q4 Annual
Total
2010/11 2011/12
PercentageofNHSTrusts
Percentage of Trust Participating in Studies
Interim Target
Final Target

11. - Quarterly
- Annual
Activity Report Publication…

12. NIHR Clinical Research Network
Supporting the implementation of LPMS for the good of research
information…
Although the Clinical Research Network operates as one organisation,
we are made up of a number of different parts:
• Six “Topic” Research Networks (covering Cancer, Dementia and
Neurodegenerative Diseases, Diabetes, Medicines for Children,
Mental Health and Stroke)
• A Primary Care Research Network to support research in this part of
the health service
• A Comprehensive Clinical Research Network, which covers all other
disease areas

13. dfd CPMS Context diagram
CPMS
IRAS
CRN Finance Tool
Local Portfolio
Management
Systems
Commercial
CTMS
Other NHS
Organisation Systems
CSP RDMIS
Module/ LRR
NIHR Coordinating
Centre MIS
Requirements for interfacing not
currently known.
Requirements for interfacing not
currently known.
CCT
Requirements for interfacing not
currently known.
Feasibility Tool
Study and Site Data
Study and Site Data
Study Related Data
Research Activity Data
Research Activity Data
Study and Organisation
DataStudy Related Data
Study Related Data
ISRCTN Number
Study Related Data
Study Related Data
Study Related Data
Study and Organisation
Data
Initial Study Data
ISRCTN Registration
Request and Study Data
Data Form Submissions
Site Activity and Performance Data

14. Version
2.0
Strategic
Alignment
and
Change
Modular
design
ODS
Codes
ODS
codes
HEFCE
codes
Contact
Mgmt
Service
layer
Hierarchies
Index
tables
Indexed
tables
Lookups
Tasks
by
role
“to
do”
panes
Monitor
progress
Structured
legacy
data
Sta,s,cs
package
Forecasts
Trend
analysis
Scheduled
data
cuts
Data
backups
Guaranteed
Up
,me
Planned
down
,me
Fast
Performance
Scheduled
changes
and
releases
NHS
reform
Future
proofing
Version
2.0
Commercial
delivery

15. Central Portfolio Management
System (CPMS)
What stage is it in?
Procurement activity continues on target to identify and select a preferred
supplier for the CPMS development. The programme team continue to refine
the requirements specification at pace to meet the delivery timelines.
CPMS will provide the NIHR CRN with a national information system to:
a. Capture high quality study information
b. Capture data on participant recruitment anywhere and everywhere in the
health research environment
c. Enable sophisticated reporting to support performance management and
delivery of the Networks
Programme
Planning
Requirements
gathering and
Procurement
Initiation
Procurement
– Contract
Award
Design
and Build
Train and
Deploy
Programme
Close
We are here

16. NIHR Clinical Research Network
More than simply performance management and metrics…
• Open Data Platform
• Coordinated System for NHS Permissions(CSP)
• Feasibility Tool
• Reference Data Gateway
• Interim Industry Tracker (IIT)
• Industry Costing Template
• UK Clinical Trials Gateway
• Industry Support Systems (SIP)

17. Open Data Platform

18. Feasibility Tool
Portfolio/IIT DataHES data Results

19. Reference Data Gateway
Gateway Project Pilot – Context Diagram
NIHR
Client System
NIHR
Client System
NIHR
Client System
CfH
Organisation Data Service
(ODS)
Reference Data
Gateway
Reference
Database
NHS Organisation
Change plans
Updates to NHS
Organisation Structure
Administrative updates
to NHS-NIHR
relationships
Ad hoc queries
and responses
Requests for
new entries
4.2
4.5
4.4
4.1
4.3
Reference Data Gateway
includes communications
and interfaces to all parties
CRNCC Information Management
Team (IM)
Service
Requests
Reference Data
Gateway Service
Service
Requests
Service
Requests

20. UK Clinical Trials Gateway

21. Suppor,ng
the
implementa,on
of
LPMS
for
the
good
of
research
informa,on…
A
Na,onal
Perspec,ve
Richard Corbridge, CIO