GuLF dream calibration/validation
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A presentation given at X2012 as part of a session of the GuLF study.
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GuLF dream calibration/validation
- 1. WORKING FOR A HEALTHY FUTURE Calibration of the DREAM model for the dermal exposure assessment of workers in theGuLFSTUDY John W Cherrie1, Melanie Gorman Ng1, Anne Sleeuwenhoek1, Mark Stenzel2, Richard Kwok3, Berna van Wendel de Joode4, Patricia Stewart5 1 Institute of Occupational Medicine, Centre for Human Exposure Science (CHES) 2 Exposure Assessment Applications, LLC 3 National Institute of Environmental Health Sciences 4 Universidad Nacional de Costa Rica 5 Stewart Exposure Assessments, LLC INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
- 2. WORKING FOR A HEALTHY FUTURE Calibration of the DREAM model for the dermal exposure assessment of workers in theGuLFSTUDY John W Cherrie1, Melanie Gorman Ng1, Anne Sleeuwenhoek1, Mark Stenzel2, Richard Kwok3, Berna van Wendel de Joode4, Patricia Stewart5 1 Institute of Occupational Medicine, Centre for Human Exposure Science (CHES) 2 Exposure Assessment Applications, LLC 3 National Institute of Environmental Health Sciences 4 Universidad Nacional de Costa Rica 5 Stewart Exposure Assessments, LLC INSTITUTE OF OCCUPATIONAL MEDICINE . Edinburgh . UK www.iom-world.org
- 3. Summary… • Original studies to validate DREAM • GuLF DREAM • Two examples using the adapted model • Preliminary data to help validate the adapted model 2
- 4. Original DREAM studies… • Fully described in initial paper, implemented in Microsoft Access • The accuracy was assessed by comparing DREAM assessments with measured exposure • Hands and other body parts • Variety of measurement methods, removal and interception samplers • Six different situations/agents • Spearman correlation coefficients for individual observations ranged from 0.19 to 0.82 van Wendel de Joode B, Vermeulen R, van Hemmen JJ, et al. Accuracy of a semiquantitative method for Dermal Exposure Assessment (DREAM). Occup 3 Environ Med 2005;62:623–32.
- 5. GuLF DREAM Body surface factor Emission Deposition Transfer Clothing 4
- 6. GuLF DREAM 5
- 7. Boom deployment, near shore… • Deployed by small vessels • Oil was present on the water • Occasionally had to anchor the boom • could result in the oil or oily water contacting hands. • Hands, forearms, and trouser legs probably got wet with water at times 6
- 8. Boom retrieval, near shore… • Retrieved by vessels or boats of all sizes, but on small boats mainly manual work • Significant opportunity for contact of hands, arms, legs and torso with oil and oily water • Wore safety glasses, abrasion- resistant work gloves (e.g. (leather), rubber boots, and a high-visibility garment 7
- 9. Validation and calibration • Validate and calibrate revised model against measurement data • Have identified sources of dermal exposure measurement data with contextual information that can be used to make DREAM assessments • IOM (heavy fuel oil) Oil and tar • Herrick et al (asphalt) • Soutar et al (biocides) • Hines et al (pesticides) Dispersants • Stewart et al (pesticides) • Van Wendel de Joode et al (Original DREAM data) 8
- 10. Biocide spraying… 9
- 11. Heavy fuel oil… 10
- 12. Discussion… • There are no dermal exposure data for the GuLF study! • Updated model provides a promising basis for exposure reconstruction • Some weaknesses in current model… • Evaporation and wind speed • Contaminated clothing • Water and washing • Sticky liquids! • Validation problematic because of limited data 11
Notes de l'éditeur
- Thanks, acknowledge co-authors and sponsorship
- Thanks, acknowledge co-authors and sponsorship
- For skin exposures to the hands, spearman correlation coefficients for individual observations ranged from 0.19 to 0.82. CP removal, OS surrogate skin, MWF flourescence
- Estimating alkylatedPAHsLarge part of the difference due to PF for gloves and clothing, e.g. for gloves the net PF went from 0.03 to 0.35
- R2 = 0.8
- R2 for HFO is 0.1