Aperion On-Call provides clients with on-demand access to a wide range of experienced healthcare professionals with insight into issues affecting the pharmaceutical, biotechnology, medical device, and healthcare services sectors. We are able to facilitate phone consultations, face-to-face meetings, or experts for conference symposia in order to enable our clients to make informed decisions. We are able to serve the unique information needs of a wide array of firms and professionals. No matter how large or small our client is, we approach each project with the same high standards of excellence.

1. Introduction and Capabilities
On-demand access to expertise that helps you maintain a
competitive edge
244 Fifth Avenue, Suite 2988
New York, NY 10001
1.212.726.1224

2. Aperion On-Call Overview
Aperion On-Call Our Clients
 Leading global expert network  Pharmaceutical, medical device, and
 Exclusively healthcare focused biotechnology companies
 Founded by seasoned, healthcare-industry  Institutional investment firms
professionals  Business decision makers
 Primary market research firm  Licensing executives
 Headquartered in NYC  Market research executives
 Competitive intelligence professionals
Research Areas
 Global consultancy firms
 Pharmaceuticals  Branding/ Advertising Firms
 Medical devices  Healthcare public policy/not-for profit
organizations
 Biotechnology
 Healthcare services
 Regulatory
 Reimbursement
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3. What We Do
• Manage a global network of experienced healthcare professionals providing insights on
issues affecting the pharmaceutical, biotechnology, medical device, and healthcare
services sectors
• Identify key opinion leaders that have the right expertise to answer our client’s
questions
• Provide our clients with on-demand access to our worldwide network of experts via:
• Telephone consultations
• One-on-one and group meeting
• Customized market research projects
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4. Our Network of Advisors Spans Almost All Areas of Healthcare
Therapeutic Areas Reimbursement/Managed Care
Allergy/Immunology Infectious Disease P&T hospital formulary members
Anesthesiology Internal Medicine Managed care medical directors
Cardiology Nephrology Pharmacists
Dentistry Neurology Pricing and contracting experts
Dermatology OB/GYN Branding and marketing
Endocrinology Oncology strategists
Gastroenterology Ophthalmology
General and Plastic Surgery
specialized surgery Pulmonology
Hematology Radiology
Hepatology Urology
Regulatory
Former FDA members Product liability
Patent experts lobbyists
Drug scheduling experts Medicare/
Regulatory consultants medicaid
Policy advisors policy officials
Statisticians 4

5. Why Aperion On-Call?
Commercial Assessments
Competitive Intelligence
Clinical Trial/Regulatory Assessments
Technology Assessments
Branding Strategy
Pricing & Reimbursement
KOL Mapping
Customized Market Research
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6. Questions that can be answered by using our services
Commercial Assessments
• Who will be the primary prescribers of the drug/device?
• What is the unmet medical need in a particular therapeutic area?
• Does the drug/device address the unmet medical need?
• How can drug/device be differentiated from what is currently available?
• How strong is the differentiation point?
• What therapeutic position (line of therapy) can this drug/device achieve?
• Will drug/device be put on hospital formulary?
• What percentage of patients will the drug device be used in?
• What type of patient is the best candidate for drug/device?
• What percentage of patients will drug/device be used in?
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7. Questions that can be answered by using our services
Competitive Intelligence
• Who are your competitors?
• What is the current competitive landscape?
• How will the competitive landscape look in the future?
• What is the impact of new entrants and patent expirations on your product?
• How effective are your competitors’ sales force in marketing their products to prescribing
physicians?
• What are patients saying about your competitors’ treatments and their side effects?
• What strategic marketing initiatives are my competitors implementing for their branded products?
• How has your competitor prioritized their development stage pipeline and R&D resources?
• What is your competitor’s strategy for lifecycle management?
• What are the pricing/reimbursement/formulary issues for your competitors’ products?
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8. Questions that can be answered by using our services
Clinical Trial/Regulatory Assessments
• What is the best regulatory strategy of a particular drug/device/indication?
• What is the optimal clinical trial design for an indication and phase of development?
• Clinical trial type
• Appropriate dose/schedule
• Appropriate controls
• How to estimate sample size?
• What is the ideal patient population, inclusion/exclusion criteria?
• What is the ideal clinical endpoint form a regulatory standpoint?
• What is the ideal clinical endpoint from a physician standpoint?
• What endpoints are appropriate to show clinical benefit in an indication?
• What is an acceptable safety profile for your development-stage product?
• What should the clinical development plan for our product look like to maximize its revenue
potential in a rapidly evolving therapeutic landscape?
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9. Questions that can be answered by using our services
Technology Assessments
• Is the scientific hypothesis sound?
• Is preclinical data predictive of clinical outcome?
• Making sense of pharmacokinetic and toxicology data
• Does the “animal-model” data provide a good correlate for what may be observed in human clinical
testing?
• What does the medical community think about our drug or its MOA?
• What is the predicted efficacy of the drug?
• What is the predicted safety of the drug?
• What is the predicted risk/benefit profile of the drug?
• How does the drug compare to treatments that are currently available?
• Have similar drugs been tested before? If so, what was the outcome?
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10. Questions that can be answered by using our services
Branding Strategy
• How to maximize the commercial value of development-stage and in-line products?
• How differentiated is your brand from the competition?
• What are key opinion leaders and early-adopters saying about your brand?
• How can your sales force more effectively market to physicians? What key points should my sales
force be emphasizing?
• What programs or strategies have been effective for increasing patient compliance for a particular
product?
• How do/will prescribing physicians perceive a particular drug or brand?
• How do/will patients perceive a particular drug or brand?
• What gives successful pharmaceutical brands their edge?
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11. Questions that can be answered by using our services
Pricing & Reimbursement
• What is the appropriate pricing strategy for the drug/device?
• How to reach the best pricing potential?
• Who will be the primary payer (Medicaid/Medicare/private insurance)?
• Are there any special reimbursement issues to consider (bundling)?
• What tier will the drug be placed in?
• What variables play a role in tier positioning?
• Will the drug/device be placed on hospital formulary?
• What will be the patient co-pay or price-share?
• How will changes to Medicare and Medicaid program impact your sales channels?
• How do you measure the effectiveness of your managed care contracting strategy?
• What is the pharmacoeconomic benefit of the drug/device?
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12. Questions that can be answered by using our services
KOL Mapping
• What are the key questions that need to be addressed for a particular therapeutic area?
• Who are the thought leaders in this therapeutic area that possess the expertise to answer these
questions?
• Who are the innovators and early adopters in a given therapeutic are?
• Who are the global KOLs for brands in early development?
• Who are the local and regional KOLs for brands nearing launch?
• Who are the KOLs that shape treatment guidelines?
• Who are the KOLs that would be willing to serve as advocates of our branded product to the
medical community?
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13. Custom Primary Research Projects
Customized Market Research
• We can assemble a Target Product Profile based on available clinical data
• We can design discussion guides for your telephone interviews
• We can design survey questionnaires
• We can identify the most relevant KOLs, practicing physicians and regulatory or reimbursement
experts
• We can conduct in-depth physician interviews over the phone
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14. Aperion On-Call Advantage
Adhere to highest standards of client service
• We recognize that reliable and timely information from the authoritative experts are
indispensable in guiding decision-making.
Affordable pricing
• We take great pride in being able to provide service that we believe is comparable to our
competitors but is at a significantly reduced cost to our clients. With a strong emphasis on
operational efficiency and cutting away with unnecessary "over-head" costs, we are able to
pass on these savings to our clients and make our On-Call Advisor Network available to
more clients with budgets large or small.
No sign-up or license fees
• Access to our Aperion On-Call Advisor Network is on a "pay-as-you-use" basis. Upon signing
a standard Services Agreement with our firm, each client has access to our entire On-Call
Network and is only billed after one or more consultations are completed.
No minimum use requirements
• Our clients may use our On-Call Advisor Network as much or as little as they wish.
Strict Confidentiality and Compliance policies
• We protect our clients' interests by making certain that every On-Call Advisor associated with
a Client consultation has agreed to terms and conditions that comply with industry standards
surrounding non-disclosures, insider trading and material and non-public information rules.
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15. Contact Us
244 Fifth Avenue, Suite 2988
New York, NY 10001
Tel: 212-726-1224
Email: clientservices@aperiononcall.com