1. Kirsten Anice Messick
8625 Briarwood Lane, Dublin, CA 94568, (925) 828-5236 E-mail: kmessick@gene.com
Experienced senior supervisor with over 11 years in the pharmaceutical industry.
Extensive hands-on experience with in-vivo study conduct, protocol creation and bio method
training. Currently supervising 4 direct reports and working within a team of 20 scientific
researchers supporting internal toxicology, pharmacokinetic and pharmacodynamic
biomarker pre-clinical studies.
Education/Certification:
Bachelor of Science with an emphasis in Pharmacology & Immunology, 1997
Monash University, Melbourne, Australia
Laboratory Animal Technician – AALAS certified, 2005
St. Johns Ambulance Level II Course in Basic First Aid, Melbourne, Australia, 2003
Certificate II in Animal Handling, International Correspondence School, NSW, Australia, 1999
Surgical Assisting Course for Veterinary Technicians, University of California Davis,
California, 1998
Continuing Education Course for Veterinary Technicians, Veterinary Learning Systems,
California, 1997
Key Accomplishments:
Supervisor II
 Liaison between the DMPK department and In Vivo Studies Group resulting in the scheduling of
450 in vivo studies/year
 Design and implementation of mouse hemolyzed blood sampling model to reduce animal usage
on in house pharmacokinetic studies
 Contributed to the design of a new study request system for in house small molecule
pharmacokinetic studies (SMDI in vivo scheduler)
 Participation on internal formulation advisory board assisting in and conducting in vivo studies to
establish recommended no-observed-effect-level (NOEL) and maximum tolerated dose (MTD) for
several commonly used intravenous solvents in the CD-1 mouse
 Design and implementation of the IV infusion model in MRSA infected mice
 Completed the 6 week Toxicology immersion (cross-training strategy) to gain proficiency in all
aspects of study execution
 Liaison between BASi and the IVS Group to schedule and conduct bi-annual maintenance of the
Culex automated blood sampling machines
Employment History:
Supervisor II Genentech, Inc., South San Francisco, CA (Safety Assessment Department)
(10/2012 – present)
Act as a study coordinator on pharmacokinetic and toxicology small molecule
in vivo studies. Direct supervision of 4 Research Associates. Supervisory tasks involve:
training, assisting in goal setting & development planning, conducting performance reviews,
ensuring compliance. Act as a liaison between the DMPK department and In Vivo Studies
group, scheduling small molecule PK studies and assigning study coordinators. Schedule
studies so as to ensure project timelines and needs are met as well as to maintain proper
workload balance among in vivo personnel. Perform applicable techniques in common
laboratory animal species, as mentioned above. Develop animal models, write preclinical
protocols and order animals.

2. Supervisor I Genentech, Inc., South San Francisco, CA (Safety Assessment Department)
(08/2008 – 10/2012)
Act as a study coordinator on pharmacokinetic and toxicology small molecule
in vivo studies. Direct supervision of 3 Research Associates. Supervisory tasks involve:
training, assisting in goal setting & development planning, conducting performance reviews,
ensuring compliance. Act as a liaison between the DMPK department and In Vivo Studies
Group, scheduling small molecule PK studies and assigning study coordinators. Schedule
studies so as to ensure project timelines and needs are met as well as to maintain proper
workload balance among in vivo personnel. Perform applicable techniques in common
laboratory animal species, as mentioned above. Develop animal models, write preclinical
protocols, order animals and act as a mentor.
Research Associate Genentech, Inc., South San Francisco, CA (PKPDS Department)
(07/2004 – 07/2008)
Assist the Pharmacokinetic/Pharmacodynamic Sciences and Drug Metabolism Departments
with the technical conduct of in vivo studies. Perform applicable techniques in common
laboratory animal species, as mentioned above. Develop animal models, write preclinical
protocols and assume role of study coordinator as appropriate.
Senior Research Assistant University of Melbourne, Melbourne, Australia (Pharmacology
Department) (02/2002 – 04/2004)
Assist the Clinical and Experimental Pharmacology Departments with the technical conduct
of in vivo studies. Perform applicable techniques in common laboratory animal species, as
mentioned above.
Veterinary Technician Bishop Ranch Veterinary Hospital, San Ramon, CA
(02/2000 – 02/2001)
Assisted veterinarians during surgical procedures with anesthesia induction, monitoring and
animal recovery. Performed dental cleaning & extractions, catheter placement for IV fluid
administration, blood sample collection from the jugular and cephalic veins and basic wound
care in cats and dogs.
Veterinary Technician Brandon Park Veterinary Hospital, Melbourne, Australia
(09/1998 – 01/2001)
Assisted veterinarians during surgical procedures with anesthesia induction, monitoring and
animal recovery. Performed dental cleaning & extractions, catheter placement for IV fluid
administration, blood sample collection from the jugular & cephalic veins and basic wound
care in cats and dogs. Served as a client liaison. Tasks included answering phone calls,
scheduling appointments, advising clients on basic pet care and recommending health care
products as needed.
Veterinary Technician Norris Canyon Veterinary Medical Centre, San Ramon, CA
(02/1997 – 08/1998)
Assisted veterinarians during surgical procedures with anesthesia induction, monitoring and
animal recovery. Performed dental cleaning & extractions, catheter placement for IV fluid
administration, blood sample collection from the jugular & cephalic veins and basic wound
care in cats and dogs. Served as a client liaison. Tasks included answering phone calls,
scheduling appointments, advising clients on basic pet care and recommending health care
products as needed.
Lab Skills:
 Animal Restraint (mouse, rat, rabbit, guinea pig)
 Drug Administration – IP (mouse, rat), IV (rat, mouse, rabbit, dog, cat), SC (rat, mouse, rabbit,
guinea pig, dog, cat), IM (rabbit, guinea pig, cat, dog), Oral gavage (mouse, rat, cat, dog),
continuous IV infusion (mouse, rat)

3.  Blood Collection – orbital bleed & cardiac stick (mouse, rat guinea pig), via marginal ear vein &
cardiac stick (rabbit), via cannula, lateral tail vein, cardiac stick, orbital bleed & Culex automated
blood sampler (rat)
 CSF collection – (mouse, rat)
 Brain microdialysis – (rat) both small and large molecules
 Cannulation Surgeries – jugular & femoral vein (rat), jugular vein (mouse)
 Aortic flow probe insertion (rabbit) for chronic cardiovascular studies
 L4/L5 ligation - (rat) to induce neuropathy
 Catheter Insertion – arterial and venous (rabbit)
 Behavioural testing – tail flick, hot plate, von frey fibres/allodynia (mouse, rat)
 Whole Body Perfusion (mouse, rat, guinea pig)
 Anesthesia/Euthanasia (mouse, rat, guinea pig, rabbit)
 Organ/lymph node collection (mouse, rat, guinea pig)
 Work with Radioisotopes (I-125/131, 3H, C14, In-111, Rb-86, Tc99), Cytotoxins, Armed
Antibodies (maytansenoids, auristatins), Infectious agents (influenza, MRSA)
 Work with Provantis for toxicology studies
 Whole rabbit perfusion/fixation for radiographic analysis of bone density and collateral vessel
formation
Publications:
Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R. (2015). Use of
transgenic mouse models to understand the oral disposition and drug-drug interaction potential of
cobimetinib, a MEK inhibitor. Drug Metab Dispos, 43(6), 864-8699.
Poullin P, Chen YH, Ding X, Gould SE, Hop CE, Messick K,
Oeh J, Liederer BM. (2015). Prediction of drug distribution in subcutaneous xenografts of
human tumor cell lines and healthy tissues in mouse: application of the tissue composition-based model
to neoplastic drugs. J Pharm Sci, 104(4), 1508-1521.
Choo EF, Ly J, Chan J, Shahidi-Latham SK, Messick K, Plise E, Quiason CM, Yang L. (2014). Role of P-
glycoprotein on the brain penetration and brain pharmacodynamics activity of the MEK inhibitor
cobimetinib. Mol. Pharm, 3;11(11), 4199-4207.
Chang JH, Ly J, Plise E, Zhang X, Mesick K, Wright M, Cheong J. (2014). Differential effects of Rifampin
and Ketoconazole on the blood and liver concentration of atorvastatin in wild- type and Cyp3a and
Oatp1a/b knockout mice. Drug Metab Dispos, 42(6), 1067-1073.
Liang X, Yang L, Qin AR, Ly J, Liederer BM, Messick K, Ma S, Zak M, Dragovich PS, Dean BJ, Hop CE,
Deng Y. (2014). Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix
approach using LC-MS/MS. Bioanalysis, 6(11), 1445-1457.
Thackaberry EA, Wang X, Schweiger M, Messick K, Valle N, Dean B, Sambrone A, Bowman T, Xie M.
(2014). Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and
recommended solvent dose limits. Xenobiotica, 44(3), 235-241.
Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick
K, Jia W, Liu L, Hop CE, Wong H. (2014). Investigations into the mechanisms of pyridine ring cleavage in
vismodegib. Drug Metab Dispos, 42(3), 343-351.
Boggs JW, Hop CE, McNamara E, Deng Y, Messick K, West K, Choo EF. (2014). Assessment of the
Hepatic CYP Reductase Null Mouse Model and its Potential Application in Drug Discovery Mol Pharm,
11(3), 1062-1068.

4. Author, A.A.. (Publication Year). Article title. Periodical Title, Volume(Issue), pp.-pp.
APA format example:
Nevin, A. (1990). The changing of teacher education special education. Teacher Education
and Special Education: The Journal of the Teacher Education Division of the Council for
Exceptional Children, 13(3-4), 147-148.