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The genus Shigella exclusively infects human intestine. Shigella dysenteriae is the causative agent of bacillary dysentery or shigellosis in humans. It is a diarrheal illness which is characterized by frequent passage of blood stained mucopurulent stools. The four important species of the genus Shigella are: Shigella dysenteriae Shigella flexneri Shigella sonnei Shigella boydii.
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Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
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Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment.
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Plague is caused by the bacteria Yersinia pestis, a zoonotic bacteria usually found in small mammals and their fleas. People infected with Y. pestis often develop symptoms after an incubation period of one to seven days. There are two main clinical forms of plague infection: bubonic and pneumonic. Bubonic plague is the most common form and is characterized by painful swollen lymph nodes or 'buboes'. Plague is transmitted between animals and humans by the bite of infected fleas, direct contact with infected tissues, and inhalation of infected respiratory droplets. Plague can be a very severe disease in people, with a case-fatality ratio of 30% to 60% for the bubonic type, and is always fatal for the pneumonic kind when left untreated. Antibiotic treatment is effective against plague bacteria, so early diagnosis and early treatment can save lives. Currently, the three most endemic countries are the Democratic Republic of the Congo, Madagascar, and Peru. Y. pestis survives and produces F1 and V antigens within blood cells such as monocytes, but not in neutrophils. Natural or induced Immunity is achieved by the production of specific antibodies against F1 and V antigens Antibodies against F1 and V induce phagocytosis by neutrophils Y.pestis causes plague ( a zoonotic diseases which is transmitted fron rats and rodents to humans by infected fleas) Fleas-blood sucking wingless insect of the order Siphonaptera Occasionally the infection occurs by inhaling the organism in the airborne droplets or By handling the infected rodents or domestic animals (e.g cats and dogs) that harbour infected fleas Bubonic plague Flea (bite) to humans Pneumonic plague Human to human after inhalation and>lungs though blood stream Septicaemic plague Plague-Zoonotic disease Spread from domestic rats to man by bite of rat flea Plague-greatest killer in history of mankind Severe epidemics In India-out break in 1994 (Maharashtra, Gujarat, UP, MP, Karnataka) In 2002-outbreak in Shimla Scattered natural foci still exist:kolar,Bead-Lathur belt in Maharashtra, Shimla and Uttaranchal Self limiting gastroenteritis in young children Mesenteric adenitis and inflammatory terminal ileitis in older children Systemic disease seem in aduld:bacteremia,meningitis arthlgia,erythema nodosum Pathogen of rodents, particularly guinea pigs Septicemia with mesenteric lymphadenitis similar to appendicitis Motile at 22 degree centigrade Pasteurella species are spherical, ovoid or rod-shaped cells 0.3-1.0µm in diameter and 1.0-2.0µm in length Cells are Gram negative, and occur singly, or in pairs or short chains Bipolar staining may be seen Capsules may be present All species are non-motile Facultative anaerobic Microscopy Gram-negative coccobacilli measuring 1 to 2 μm in length. Many pathogenic isolates are encapsulated Cultural characteristics Primary isolation media Blood agar incubated in 5-10% CO2 at 35-37°C for 16–48hr ,Colonies are grey and viscous but rough irregular colonies occur
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Yersinia 2007
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