46. at MDD/SD = 0.1, N=1944 Estimate of Required N (per cohort) for 80% power, ďĄ = 0.05 How Large Must the Cohorts Be? 0 50 100 150 200 250 300 350 400 450 500 Required N per Cohort 0 0.25 0.5 0.75 1 1.25 1.5 Minimum Detectable Difference / Std. Dev