Test

1. Jimmy Santana, MBA, P.A. - C
1
3/13/2009

3.  A 24-year-old, white female has recently being diagnosed with insulin-dependent
diabetes. The disease is being managed on a split dose of 60/40 insulin suspension,
which she injects herself at 8:00 a.m. and 5:00 p.m. She was told to call in if she
experiences any strange symptoms, which she does this afternoon. At 2:45 p.m. she
is not feeling well and notices that her skin is cool and damp. Her hands are
shaking and she is very anxious. What do you tell her to do right away, before
having somebody take her to your office?

A. Inject 4 IU of her insulin

B. Drink a can of diet soda

C. Drink six ounces of fruit juice

D. Eat a large candy bar

E. Eat a cube of sugar

4.  The above described symptoms are classical for hypoglycemia.
An inexperienced patient needs to be monitored by medical
personnel until the blood glucose level is stabilized again. The
first priority though is to prevent the blood sugar to drop any
further and send the patient into a coma.
 A six-ounce drink of fruit juice should be sufficient. Since the
symptoms suggest hypoglycemia, injecting insulin would
worsen the situation. If in doubt if the patient is hypo- or
hyperglycemic and there is no possibility for a test, always give
sugar first and see if the patient improves. An increase of a blood
glucose level of, for example, 350 is not going to hurt the patient,
but lowering a level of 45 is going to send the diabetic into a
coma.
 Since diet soda contains only sugar substitutes it is not going to
influence the blood glucose level. A large candy bar could be
eaten too, but it may raise the glucose level higher than required,
therefore the fruit juice is a better choice. One cube of sugar is
an insufficient amount to raise blood sugar; it will take several
cubes.

5.  A 61-year-old white male presents to your office for the first time. In
reviewing his medical records, you note a history of diabetes type 2
onset 4 years ago. He is currently well controlled to normal blood
sugars and hemoglobin A1Cs. You do note that his previous blood
pressure readings were above normal on multiple visits. In addition to
his usual diabetic care, you recommend initiation of drug therapy for
his hypertension. Your drug of choice is
 A. Calcium channel blocker

B. ACE inhibitor

C. Alpha blocker

D. Thiazide diuretic

E. Beta blocker

6.  ACE inhibitors have been shown to slow the progress
of proteinuria in patients with diabetes. Control of
their blood pressure is just as important. Your drug of
choice should be an ACE inhibitor for any diabetic
with hypertension as long as there are no
contraindications to giving them this medicine.

7. A 55-year-old male is brought into the urgent care center of your hospital by paramedics. He is
3.
obtunded, and today his wife could not get him out of bed. He has no significant past medical history. His
wife states that he has not been well for the last week, with decreased energy and fatigue. In addition, he
has had a productive cough, which has worsened during the last 3 days. Also, according to his wife, he
appears to be drinking more water. Physical exam reveals a lethargic male who moves to deep pain but
has no intelligible speech. Paramedics have given the patient Narcan with no change in his status but
have withheld glucose bolus due to a high dextro stick reading. Vital signs are pulse 115; BP 90/50;
respiration 18; Temp 38.2° C (100.7° F)
HEENT shows dry mucous membranes. Lungs are clear. Cardiac exam is significant for tachycardia.

Abdominal exam is nonspecific. Neurologic exam shows the patient to be responsive only to pain, with
withdrawal. No abnormal reflexes noted.
Initial laboratory studies show: Na 118; K 4.2; Cl 97; HCO3 21; Glucose 1050. ABG reveals pH 7.34, pCO2

20; pO2 79; O2 saturation 90%. CBC shows a normal H/H with WBC count of 14K; the serum is reported
as very lipemic. Chest X-ray shows an LLL consolidation. The most likely cause for the change in the
patient's mental status is
A. Acute diabetic ketoacidosis

B. Pseudohyponatremia

C. Pneumococcal pneumonia with hypoxia

D. Hyperglycemic hyperosmolar nonketotic coma

E. Central pontine myelinolysis


8.  Hyperglycemic hyperosmolar nonketotic coma (HHNC) represents a
syndrome characterized by marked hyperglycemia, hyperosmolarity, and
dehydration. It is manifested by decreased mental functioning that may
progress to frank coma. Ketosis and acidosis are generally minimal.
DKA, acute diabetic ketoacidosis, will have similar electrolyte

abnormalities; however, there will be an associated metabolic acidosis and
ketosis.
The patient does show pseudohyponatremia, which is due to the presence

of hyperglycemia and hyperlipidemia. In the absence of marked lipemia,
the true value for sodium can be approximated by adding 1.3 to 1.6 mEq/L
to the sodium value for every 100 mg/dl glucose over the norm. But this is
not the cause of this patient's altered sensorium.
The patient most likely has pneumococcal pneumonia, which is a

common precipitating factor in the development of HHNC. He is mildly
hypoxic, though this does not explain the degree of obtundation seen.
Overly aggressive restoration of serum sodium levels in hyponatremic

patients can be associated with central pontine myelinolysis and
circulatory overload.

9.  A 28-year-old type I diabetic on multiple daily insulin injections regimen
presents to your office for a follow up visit. She complained to you about her
early morning glucose level during her last visit and you recommended for
her to chart the numbers and bring it for her next appointment. Her pre-
breakfast glucose averaged 285mg/dL; dinnertime was 95mg/dL and
68mg/dL at 3 AM. How will you treat her diabetes?
 A. Increase the evening dose of long acting insulin
 B. Decrease the evening dose of long acting insulin
 C. Decrease the evening dose of short acting insulin
 D. Increase the evening dose of short acting insulin
 E. Increased activity before bedtime

10.  Three mechanisms can account for early morning hyperglycemia in
patients with diabetes on insulin:
1. Inadequate dose of long acting insulin at night
2. Somogyi effect or rebound hyperglycemia is a condition often seen in
type I diabetes, in which there is nocturnal hypoglycemia. The
hypoglycemia subsequently stimulates the release of counter regulatory
hormones leading to increase of glucose level in the blood. Diagnosis
can be made by several plasma glucose analyses done at 2.00 A.M, 3.00
A.M, and 7.00A.M.
3. In the dawn phenomenon, the hyperglycemia is secondary to increased
need for insulin in the early morning due to the normal early morning
surge of growth hormone, which antagonizes insulin action.
 Checking the blood glucose level at 3 AM can help differentiate
between Somogyi effect and dawn phenomenon: the level will be low
in Somogyi phenomenon. The patient's early morning hyperglycemia is
due to Somogyi effect since her 3 AM level was low. Treatment of this
will be to decrease the evening dose of long-acting insulin or give
bedtime snacks. The treatment of dawn phenomenon involves
increasing the evening dose of long-acting insulin.
 There is no nocturnal hypoglycemia if the night dose of insulin is
inadequate.

11. A 62-year-old male with a history of diabetes for twenty-five years and hypertension for

ten years is referred to your office by a retired physician. He complains of worsening
edema on the right lower extremity during the last two weeks. Vital signs show T 97.8
Pulse 78 RR 20 BP 165/93. Physical examination disclosed periorbital edema and left
lower extremity edema 1+ below the knee and right lower extremity edema 3+ below the
knee that is nontender to palpation. He denies any fever, chills, or malaise. He is
currently on glipizide 20 mg twice a day and amlodipine 10-mg once daily. Laboratory
result from two weeks ago shows Na 145, K 4.5, Cl 102, HCO3 25, BUN 14, Creat 1.2, CA
7.2, Glucose 287, HgA1C 8.6, and Albumin 2.5. The U/A test shows 3+ proteins with no
WBC or RBC.
Question: What is the most appropriate next step in management of his diabetes?
A. Start the patient on glyburide

B. Start the patient on insulin therapy

C. There is no indication to change his diabetes therapy. His HgA1C shows that his

diabetes is under control
D. Start the patient on metformin

E. Repeat the patient's HgbA1C; result is too old to reflect the current HgbA1C level


12.  This patient's diabetes mellitus is poorly managed. Glycosylated
hemoglobin (HbA1c) is the best indicator of glycemic control
over the previous 3 months. Maintaining an HgA1C of 7 or less
lowers the rate of complications of diabetes mellitus. Adding a
second class of oral hypoglycemic agent would be the next best
choice. Metformin is the drug from the biguanides class;
therefore, it is the drug of choice.
 Starting the patient on glyburide is incorrect because both
glyburide and glipizide belong to the sulfonylurea class. Starting
the patient on insulin therapy is incorrect because oral therapy
should be maximized before starting on insulin. HgA1c of 8.6
indicates poorly controlled diabetes. There is a need to change
his diabetes management. There is no need to repeat HgA1C.
Glycosylated hemoglobin (HbA1C) is the best indicator of
glycemic control over the previous 3 months. The result is not
too old.

13.  A 38-year-old obese female with type 2 diabetes mellitus presents to your office
for follow up visit. Her blood sugar has been well controlled on metformin. She
wants to have a baby and wants to know if there is any special thing to do so
that her diabetes will not affect her pregnancy. Which of the following is
appropriate for her?
 A. Switch her to insulin
 B. Switch to glyburide
 C. Tell her it is not advisable for her to be pregnant because her child will be
diabetic
 D. Increase the dose of her metformin to prevent worsening of her blood sugar
during pregnancy
 E. Continue her present treatment and dose

14.  Diabetic patients that are pregnant or attempting to
get pregnant, irrespective of whether they are insulin
requiring or not, should be switched to insulin
therapy for their glucose control. Oral glucose
lowering agents are contraindicated in pregnancy.
Although a poor glucose control predisposes to
increased maternal and fetal risks, it is not a
contraindication to pregnancy. A good glucose control
is however necessary prior to and during pregnancy.

16.  A 24-year old white male present to the flight
physician assistant’s office for a routine physical. He
has been taking flying lessons and is applying for a
pilot’s license. Regulations state that he must have a
physical examination.
 Examination discloses a thin male, 74 inches, 140
pounds. Generally, the exam is unremarkable. Routine
screening includes a urinalysis, which demonstrates
4+ glycouria.
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3/13/2009

17. There is insufficient information to establish a diagnosis.

There are other reasons to spill glucose in the urine. You
must ask additional questions.
You find out that even though he denies any history of

diabetes, he admits to:
Having incessant thirst
1.
Increase hunger
2.
Increase urination
3.
He has lost 15 pounds over the last three months
4.
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3/13/2009

18.  A glucometer reading revealed a glucose of 490 mg/dl
 A blood glucose revealed a glucose level of 496 mg/dl.
With normal electrolytes and anion gap
 Does this patient have diabetes?
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3/13/2009

19.  Three ways to diagnose diabetes mellitus:
 Fasting glucose of > 126 mg/dl
 Oral glucose tolerance test with a 2 hr value
of > 200 and one other value in-between of
> 200
 Grossly elevated serum glucose with classic
signs and
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3/13/2009

20.  New onset Type I diabetics should be
admitted because:
 He needs to start on insulin
 He requires a lot of patient education
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3/13/2009

21.  32-year old woman who has type I diabetes calls
you over the weekend. She has been having some
nausea and vomiting for the last 24 hours and can
not keep solids down. She has been able to keep
liquids down. Her last glucometer reading was
261 mg/dl.
 She is on a split dose of NPH and regular insulin
twice daily. She did not take her morning insulin
because a physician had told her never to take her
insulin when she is not eating. She ask you for
instructions?
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3/13/2009

22.  Many patients do not take their insulin if they
are not eating; this is wrong.
 It is important for IDDM patients and their
providers to learn how to manage “sick days”.
 Note that one of the most common reasons for
patient to go into DKA is poor management of
their diabetes when they are sick.
 Insulin should be taken regardless of whether or
not they are eating
 Adequate carbohyrates should be taken (15 –
20g q2h)
22
3/13/2009

23.  The patient can consume regular coke, Sprite,
juices @ 4 – 6 oz q2hrs.
They can also have gelatin, crackers, soup

Patients that are sick require more insulin

NOT less
The intermediate or long acting insulin should

be given
Regular insulin should be given q4h as per a

‘sliding scale’
23
3/13/2009

24.  69-year old white female was in good
health until 3 weeks ago, when she
suddenly developed severe polyuria,
polydipsia and polyphagia. She has lost 20
pounds ( going from 120 to 100) during
that period and feels extremely weak.
When her daughter brings her to you, in
the ED, she is somewhat lethargic. Past
medical history reveals HTN(Tx with a
small dose of enalapril). There is no
history of cardiac disease.
24
3/13/2009

25.  Physical Exam reveals a pale, lethargic,
confused woman, breathing rapidly.
 B/P is 102/72 P 110 Resp 32
 Her skin is very dry, bowel sounds are weakly
positive
 Blood test revealed
Na+ 130 (135 – 145)

K+ 5.1 (3.5 – 5.1)

Glucose 794 ( 70 – 110)

Cl- 104 (95 – 105)

HCO3 3mEq/L (21 – 30)

pH 6.92 (7.35 – 7.45)

pO2 92 mm (80 – 105)

25
3/13/2009

26.  A 37 year old white female has a 20 year
history of diabetes mellitus. She has
been having difficulty with
hypoglycemia in the early morning. She
used to be on beef-pork insulin and did
not have any problems.
 She takes:
 Human NPH 16U am; 8 U pm
 Human Regular 8 U am; 3 U pm
26
3/13/2009

27.  Blood glucose monitoring reveal:
3am 7am 12pm 5pm
41 66 109 72
47 132 82 100
35 182 134 142
 Why is she developing early-morning
hypoglycemia?
27
3/13/2009

28.  Insulin have different peaks and duration of
action.
 In this case you must note that animal insulin has
a slower peak than human insulin
 In this case this lady was advised to move the
NPH evening dose to qhs --- which allowed the
NPH peak to occur later
 To cover the evening problem one should also
increase the bedtime regular insulin --- in this
case it was increased by 2 U
28
3/13/2009

29.  A 56-year male has a history of type II diabetes for 10
years. He is currently on glipizde 20 mg BID and
monitors his glucose twice a day. Over the last 2 weeks
his fasting glucose were 157 – 278 (average 199); supper
values were 145 – 292 (average 212).
29
3/13/2009

30.  Yesterday his fasting glucose was 234 and
HgA1c was 14.8%
 P.E.: B/P 142/90 P 72 Resp. 12 height:72 inches
weight: 212
 The rest of the physical was normal with no
evidence of retinopathy or neuropathy
 What is the best option for this patient?
30
3/13/2009

31.  Though this patient may not want to go
on insulin …. We have no choice.
 He has unacceptably high glucose
values
 HgA1C confirms the fact that insulin is
needed
 What do we start him on?
31
3/13/2009

32.  Many clinicians start their type II that now
require insulin on NPH or ultralente and add
regular insulin later as needed to tune – up
treatment.
 After knowing what it would take to treat this
patient --- you may then decide to use pre-
mixed insulin.
 Should this patient be hospitalized?
 No
32
3/13/2009

33.  A 30-year female has no prior medical
problems. As part of a routine obstetric
care, she has a glucose screen at 24 weeks.
She is given 50-g glucose to drink and a
glucose level is obtained 1 hour later. Her
results revealed a level of 156 mg (<140)
 She is 64 inches tall and weighs 220
 What do you do know?
33
3/13/2009

34.  You should now order a 3 hr GTT,
which they give 100 g of glucose
 Her results were
 Fasting: 112mg
 1hour: 183mg
 2hour: 172mg
 3hour: 147mg
 What is your opinion?
34
3/13/2009

35.  This patient has Gestational Diabetes. According to
the National Diabetes Data Group – Dx is made if two
or more values exceed the norm.
 You should start this patient on a ADA 2000 calorie
diet, give her a glucometer(she to take readings four
times daily) and see her in a week.
35
3/13/2009

36.  You see her back in a week and her glucose log reveal:
Fasting LunchSupper Bedtime
97 93 115 104
112 101 107 99
101 101 89 122
93 105 102 111
115 112 121 118
99 107 113 105
96 101 117 109
36
3/13/2009

37.  What should you do now?
 This patient should be started on insulin.
Though these level appear good; in pregnancy
glucose levels are significantly lower.
 Target glucose goals are:
Fasting: 60 – 90

Non-fasting (before breakfast) 60 – 105

After meals: < 120

2am – 6am: >60

37
3/13/2009

38.  Since most of these patients seem to be insulin
resistant it is recommended to start with
0.6U/kg/day. In this patient we would give 30 –
32 U NPH (or Longer acting) BID. She returns
in four days with the following readings:
Fasting LunchSupper Bedtime
93 99 97 122
86 100 98 113
74 78 99 107
68 90 79 112
38
3/13/2009

39.  How is our patient doing?
 These reading show that we still have a problem at
bedtime. Therefore, we should add 2U of regular
insulin in the evenings
39
3/13/2009

40. 40
3/13/2009

41. A 58 year-old man with a 12 year history of type 2 diabetes comes to
your office because of an ulcer in his right foot. Physical exam
reveals a 1-cm irregular ulceration over the right metatarsal
head, surrounded by an area of black gangrenous skin. The
patient is admitted and undergoes amputation of the right
forefoot. Which of the following would have been most
effective in preventing this complication?
Appropriate instructions on self-care of the feet
A.
B. Doppler exam of the lower extremities
C. Nuerophysiologic and electromyographic studies
D. Local application of platelet-derived growth factor
E. Prophylactic treatment with cholesterol-lowering agents
41

42. Screening
1.
Current guidelines
2.
Use of oral agents
3.
Insulin regimens
4.
Gestational diabetes
5.
42

43. 45 years old; repeat q 3 years

Overweight (BMI 25 kg/m2*)

Physically inactive

Have a first-degree relative with diabetes

High-risk ethnic population

h/o GDM or baby >9 lbs

HTN

Hyperlipidemia

PCOS

Other sx of insulin resistance (acanthosis)

h/o vascular disease

43

44. Symptoms of diabetes and a casual plasma glucose 200 mg/dl or..
1.
FPG 126 mg/dl ( no caloric intake for at least 8 hr) or…
2.
BS 200 mg/dl after OGTT (2 hr after 75 gm glucose).
3.
In the absence of unequivocal hyperglycemia, these

criteria should be confirmed by repeat testing on a different
day.
OGTT is not recommended for routine clinical

use, but may be required in the evaluation of patients with
IFG or when diabetes is still suspected despite a
normal FPG as with the postpartum evaluation of women
with GDM.
44

45. A1C<7.0% (q 3 mo if uncontrolled; twice yr if at goal)

Preprandial BS 80-110 mg/dl (60-90 if pregnant)

Postprandial BS<140 mg/dl (<120 if pregnant)

Blood pressure<130/80 mmHg

LDL<100 mg/dl

Triglycerides <150 mg/dl

HDL>40 mg/dl

Annual influenza vaccine

Pneumococcal vaccine for adults with diabetes

Revaccination is for individuals >64 if vaccine was

administered >5 years ago. Other indications for repeat
vaccination include nephrotic syndrome, chronic renal
disease, and other immunocompromised states, such as
after transplantation.
45

46.  SMBG TID w/ DM1 and GDM
 BP each visit
 Annual urinary microalbumin (<30ug/mg)
 Annual lipids
 Annual optho exam starting 3-5 yrs after onset w/
DM1, and upon diagnosis in DM 2
 Visual foot exam each visit. Comprehensive exam
yearly (sensation, biomechanics, foot structure,
vascular status and skin integrity)
46

47. 47

48.  Risk assessment at first prenatal visit
 Low-risk status requires no glucose testing
 Age <25 years
 Weight normal before pregnancy
 Member of an ethnic group with low prevalence
 No known diabetes in first-degree relatives
 No history of abnormal glucose tolerance
 No history of poor obstetric outcome
 High risk features (obesity, h/o GDM, glycosuria,
or FH) should undergo glucose testing as soon as
possible
48

49.  FPG 126 mg/dl or a casual plasma glucose 200 mg/dl meets the threshold
for the diagnosis of diabetes (confirm on subsequent day)
 High-risk women not found to have GDM at initial screening and average-
risk women should be tested between 24 and 28 weeks of gestation.
Testing should follow one of two approaches:
One-step approach: 100-g OGTT

 95 mg/dl fasting
 180 mg/dl at 1 h
 155 mg/dl at 2 h and 140 mg/dl at 3 h.
*Two or more of the plasma glucose values must be met or exceeded for a
positive diagnosis
 Two-step approach: perform an initial screening by measuring the plasma
or serum glucose concentration 1 h after a 50-g oral glucose load and
perform a diagnostic 100-g OGTT on that subset of women exceeding 140
mg/dl
49

50. Drug Class Mechanism of Action Side Effects
↑insulin secretion
Sulfonylureas/ secretagogues weight gain, hypoglycemia
↓hepatic glucose output
Metformin GI upset, lactic acidosis,
TZD’s ↑ peripheral glucose fluid retention, weight gain
disposal
↓ intestinal
Alpha-glucosidase inhibitors flatulence, diarrhea
carbohydrate
absorption
*Each will lower A1c by 1-2% compared to
placebo. When combined, efficacy typically
is additive
50

51. Sulfonylurea + Metformin
Sulfonylurea + α-glucosidase inhibitors
Sulfonylurea + TZD
Metformin + Secretagogues
Metformin + TZD
Insulin + Sulfonylurea
Insulin + Metformin
Insulin + TZD
51

52.  Know the types of insulin and onset
 Know how to adjust insulin
 All regimens include basal and bolus
52

53. •Make changes slowly, taking into account diet, activity,
stress
•Asses the effectiveness of insulin at its peak time of
action
•Increase short/rapid insulin based on post-prandial
readings
•Increase long-acting when BG high fasting or
throughout day
•Inject into subcutaneous abdomen and rotate sites
53

54.  To ↓ pre-dinner BG…….↑AM intermediate-acting (e.g.,
NPH)
 To ↓ fasting BG……….. ↑PM long/intermediate-acting
insulin (e.g., glargine, NPH)
 To ↓ pre-lunch BG……..↑AM short/rapid-acting insulin
(e.g., regular, lispro, aspart)
 To ↓ bedtime BG…...….↑PM short/rapid-acting insulin
(regular, lispro, aspart)
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3/13/2009

55.  Onset within 24 hours
 Diabetic ketoacidosis DKA
 usually seen with Type 1
 Liver cannot metabolize and kidneys cannot excrete
 Hyperglycemia (>250)
 Ketosis (positive urine dipstick)
 Metabolic acidosis (HCO3 < 15; pH <7.3)
 May mimic “flu” Polyuria, polydipsia, nausea,
vomiting, abdominal pain, breath smells like booze.

56. Decreased insulin, high counterregulatory hormones
(catecholamines, glucagon, GH, cortisol), leading to
hyperglycemia, proteolysis, lipolysis & ketone production
Diagnostic Criteria
hyperglycemia: glucose>250 mg/dl

acidosis: pH <7.35; HCO3 < 18

ketosis (blood &/or urine)

Therapeutic Goals
Improve circulating volume & tissue perfusion

Identify precipitating factors

FLUIDS restores intravascular volume, decreases

counterregulatory hormones and lowers glucose levels
Reduce Gluc. & serum osmolarity: lytes q2, glucose q1

Clear ketones, fix electrolytes

56

57.  HHNK - Hyperglycemic, hyperosmolar, non-
ketotic coma. Onset 2 days to 2 weeks.
 Osmolarity > 310
 Glucose > 600
 Usually seen with Type 2
 exhibiting increasing insulin resistance, esp. after gorging
on CHO.
 Presents with marked dehydration and CNS SSx
often mimicking a stroke.
 Must correct S-L-O-W-L-Y to prevent cerebral
edema. Watch K+ levels.

58.  Hypoglycemia
 Glucose < 50
 Causes:
 Not enough to eat (or forgot)
 Too much insulin (or pills)
 Did not allow for exercise
 CNS- confusion, delirium, coma
 Autonomic - hunger, anxiety, SWEATING, tachycardia.
 If patient is conscious - give OJ. Otherwise injection of
glucagon, glucose gel in mouth, or 50% glucose by IV
push.

59.  Neuropathies - peripheral
 Obstruction of vessels that supply nerves
 Demyelination
 Sensory
 Paresthesias
 Decreased sensitivity to pain, temperature and light
touch.
 Decreased proprioception and vibration sense.
 Motor
 Weakness
 Atrophy

60.  Neuropathies - central and autonomic
 orthostatic hypotension
 gastrointestinal atony
 atonic urinary bladder
 impotence
 impairment of special senses

61.  Nephropathy
Glomerulosclerosis (arteriolonephrosclerosis)

Thickened basement membrane in glomerulus

Causes microalbuminuria (300 mg / day)

Nodular scarring and destruction of glomerulus.

Kimmelstiel - Wilson lesion. Pathognomonic for
diabetes mellitus.

62.  Retinopathy
 Leading cause of blindness. DM has increased risk
for cataracts and glaucoma
 Pathogenesis:
 new vessels, fragile vessels, microaneurysms,
hemorrhage. Followed by scarring and retinal
detachment. Takes 20 years to develop. 100% of
Type 1; 60% Type 2. Need to evaluate yearly.
Retinal photos excellent.

63.  Foot ulcers
 Most common reason for hospitalization
 Due to impaired circulation (PVD)
 Abnormal glycoprotein thickens vessel wall
 Chronic hypoxia (glycohgb has > affinity for O2)
 Due to neuropathy
 Cannot feel pain to prevent injury
 Prevention: Wear good closed-toe shoes, white
cotton socks, keep feet clean and dry, clip toenails
straight across, inspect feet daily.

64.  Infections
 Skin: boils and abscesses
 Urinary tract infections - quickly spread to kidneys
 Osteomyelitis
 Infected cuts of extremities
 Peridontal disease
 Finger and toenail fungus