This document discusses the risks of acute respiratory failure (ARF) during endoscopic procedures and presents a potential market for immediate ventilation devices. It notes that every day in European countries 0.01% of the population undergo endoscopic procedures, and 5% of those patients develop ARF. Based on population statistics, this results in 3,655 to 6,579 new ARF cases per day across Europe, including 305 to 549 new cases per day just in Italy. Currently physicians face a dilemma in treating ARF, as non-invasive ventilation has errors and risks, and intubation has its own risks and costs. The document estimates the potential market size for immediate ventilation devices used during endoscopic procedures to be 219,300 units per

1. Michel Sainville
Marketing Division

2. Background informations
Advances
in endoscopic
technology
Longer
procedures,
deeper sedation
Higher ARF risk

3. ARF Statistics
Every day, in each european country, the 0,01% of
the population undergoes an UE.
The 5% of those patients develops an ARF.
(P/10k)(0.07 ± ε)Time

4. Europe= (731mln/10k)(0.07 ± 0.02)1
3˙655 to 6˙579 ARF per day.
Italy= (61mln/10k)(0.07 ± 0.02)1
305 to 549 ARF per day

5. Physician’s dilemma
Treating ARF
Non invasive
ventilation
Planned
Prediction
errors
Unexpected
Procedure
interruption
Intubation
Risks
Costs

6. Immediate and unplanned intra-procedural ventilation

7. Physician’s dilemma
Treating ARF
Non invasive
ventilation
Planned
Prediction
errors
Unexpected
Procedure
interruption
immediate
ventilation
Intubation
Risks
Costs

8. Applications
• Tracheal intubation
Emergency
department
• FOB: fiberoptic bronchoscopy
• Gastroscopy
• Enteroscopy
• TEE: trans-esophageal echocardiography
• EBUS: endobronchial ultrasound
• ERCP: Endoscopic retrograde
cholangiopancreatography
Endoscopic
procedures

9. MARKET SIZE

10. Assumptions
• Fewest ARF scenario
• Even treatment proportions
• Intra-procedural ventilation only (- NIV, CPAP)

11. EU market size
219˙300 units per year
Italian estimated market size
18˙300 units per year

12. Thank You