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Effectiveness of CBT for anxiety
disorders in mental health clinics and
  in schools as indicated prevention

     Bjåstad JF1, Wergeland GJH1,2, Høye, A3, Fjermestad KW1,2,
  Haugland B1,4, Oeding, K1, Öst LG 1,5, Havik O 1,2, Heiervang ER, 1,6.

         1 Anxiety Disorders Research Network, Haukeland University Hospital, Norway
                               2 University of Bergen, Norway
                                 3 Fjell Municipality, Norway
                                   4 Uni Research, Norway
                               5 Stockholm University, Sweden
                                6 University of Oslo, Norway
Background
• The effect of CBT for childhood anxiety disorders is well
  documented in university clinic settings

• Results may not be valid in regular outpatients clinics
   – Recruited vs referred children
   – Homogenous sample
   – Differences in therapist training


• Few effectiveness studies in clinical settings
• Few effectiveness studies on the use of CBT as indicative
  prevention in the school health system
Study questions:
1. Is ”FRIENDS for life” effective for the treatment of anxiety for
   children and adolescents in an outpatient setting?


2.   Is ”FRIENDS for life” effective as an indicated prevention
     program in a school/youth health center setting?
Assessment and Treatment- Anxiety in
Children and Adults (ATACA)
 A randomized, controlled, multisite, effectiveness study
 of the CBT programme ”Friends for life”.

 PI Einar R. Heiervang, Professor
 PI Odd E. Havik, Professor


 Grant from Western Norway Regional Health Trust
Study sites
 No of clinics:      7
 No of therapists:   16
 No of assessors:    16
Methods
 Participants
 • 8-15 year olds, ordinary referrals with a primary anxiety
   disorder diagnosis
Methods
Inclusion/Exclusion
• Inclusion
   – Separation (SAD), Social (SOP), or Generalised (GAD) anxiety
      disorder. (ADIS-C/P; CSR>=4)

• Exclusion
   – Autism spectrum disorder
   – Intellectual disabilities
   – Obsessive-compulsive disorder
   – Severe conduct problems
   – Unstable medication
Methods
Intervention
• Friends for Life, 4th ed (Barrett; 2004, 2005)
     – Group and Individual format
     – Child (8-12) and Youth (12-15) versions


   F     - feeling worried ?
   R     - relax and feel good
   I     - inner thoughts
   E     - explore plans
   N     - nice work so reward yourself
   D     - don’t forget to practice
   S     - stay calm, you know how to cope now
Methods
Measures

• Anxiety Disorders Interview Schedule
  – (ADIS IV-C/P; Silverman & Albano, 1996)



• Spence Children’s Anxiety Scale
  – (SCAS; Spence, 1995)


• Short Mood and Feelings Questionnaire
  – (SMFQ; Angold et al., 1995)
Sample characteristics
                            Total sample N=182
                        M (SD)              %
Gender
 Male                                    47,0 %
 Female                                  53,0 %

Age (mean, SD)        11.54 (2.08)

Age group
 8-12 yrs                                66,0 %
 12-15 yrs                               34,0 %

Comorbidity present                      77,5 %

Primary diagnosis
 SAD                                     33,0 %
 SOP                                     46,0 %
 GAD                                     21,0 %
Is ”FRIENDS for life” effective for the
 treatment of anxiety for children and
adolescents in an outpatient setting?



               Results
Active treatment vs wait list
80,0 %


70,0 %


60,0 %


50,0 %
           43,3 %

40,0 %                                                        Post treatment
                                                              After Wait list
                                       31,1 %
30,0 %


20,0 %
                          13,9 %

10,0 %
                                                     2,8 %

 0,0 %
         No longer primary diagnosis   No anxiety diagnosis
Group- vs individual treatment
100 %

90 %

80 %

70 %

60 %
                          50 %
50 %
                                                            Group
40 %       38 %                                     38 %
                                                            Individual

30 %                                  25 %

20 %

10 %

 0%
        No longer primary diagnosis   No anxietydiagnosis
Diagnostic Recovery Rates

• By age
   – Children        41%
   – Adolescents     38%


• No statistically significant differences with respect to age
  group/treatment format an diagnostic recovery rates
SCAS and SMFQ
• Moderate effect sizes found for
   – SCAS self-report
   – SCAS parent report


• Moderate effect sizes found for
   – SMFQ self report
   – SMFQ parent report


• No statistically significant differences between ICBT and
  GCBT on SCAS and SMFQ
Conclusions

• CBT is effective in the treatment of anxiety with children and
  adolescents in ordinary outpatient clinics.

• No significant effect found for treatment format post-treatment
  (group versus individual).

• Dropout rate lower than in ordinary outpatient clinics.
An early school-based group intervention for
youths with anxiety and depression
symptoms

 A study of the CBT programme ”Friends for life”.
 in Fjell Municipality, Norway
Methods
 Participants
 • 36 children/ adolescents from 8 schools with anxiety
   and/or depression symptoms
 • Ages 8-15 yrs old (M= 11.8)
 • 12 boys and 24 girls

 Recruitment
 • Recruited through contact with the school health-service
   or psychologist working in the municipality
Methods
 Measures
 • Spence Children Anxiety Scale; SCAS (Spence,1998).

 • The Mood & Feelings Questionnarie; MFQ (Costello &
   Angold, 1988).

 • The Strength and Difficulties Questionnarie; SDQ
   (Goodman,1997).
Methods
 Design
 • Open non-randomization study.
 • Included 3 months follow up (only child report)

 Intervention groups
 • Total of 4 ”FRIENDS for life” groups
 • 2 in primary school, 1 in secondary school and 1 at a
    Youth Health Centre.
SCAS
                   40
                   35
                   30
SCAS total Score




                   25
                   20                          Parents
                   15                          Children
                   10
                    5
                    0
                        Pre   Post     3 mnt
MFQ
                  25

                  20
MFQ total score




                  15
                                             Parents
                  10
                                             Children

                   5

                   0
                       Pre   Post    3 mnt
Conclusions

• The “FRIENDS for life” program was effective in reducing anxiety
  and depression symptoms in this sample

• The children and adolescents reported that they liked participating in
  the groups, and dropout-rate was low (8%).

• The school health service can be an important arena for
  implementing CBT as indicated prevention
Implications
• ”FRIENDS for life” is effective in regular
  mental health clinics and as an indicated
  prevention program in the school health
  service system.
Limitations
• Preliminary results
• Limited sample size
• No follow up
Thank you




email: bjaastad@gmail.com
Project Group – ATACA study
•   Einar R. Heiervang, Professor, University of Oslo
•   Odd E. Havik, Professor, Institute of Clinical Psychology, University of Bergen.
•   Bente S. Haugland, Dr. Psychol. Centre for Child and Adolescent Metal Health, Western Norway
•   Kristin Oeding, Cand. Psychol. Institute of Clinical Psychology, University of Bergen
•   Gerd Kvale, Professor, Institute of Clinical Psychology, University of Bergen.
•   Jon F. Bjåstad, Doctor of Clinical Psychology, Clinical supervisor
•   Gro Janne H. Wergeland, Cand. Med., PhD-student, Insitute of Clinical Medicin, University of
    Bergen.
•   Krister W. Fjermestad, Cand. Psychol, PhD- student, Institute of Clinical Psychology, University
    of Bergen.
•   Lars G. Öst, Professor, Institute of Clinical Psychology, University of Bergen/ Stockholm
    University.
•   Robert Goodman, MD PhD, professor, Institute of Psychiatry, King's College London.
Timeframe ATACA study: Child part
       2007            2008           2010                             2015


   Clinical trials   Main study      182 pts                       End of 5 year
   Instruments       inclusion      included                        follow-up
       Pilot                      Last treatment                   assessment
                                   by 02/2011.




   2006                                                2011


Organization                                       End of 1 year
  Design                                            follow-up
Recruitment                                        assessment
Flow Chart
                              Invited
                               N=258

                       Assessed for eligibility
                               N=222


                           Enrollment
                              N= 182

                          Randomisation




              Group         Individual             WL N= 38
                              N=77
               N= 67
                                                  Assessment and
             Post-treatment assessment                  re-
                                                   randomisation


                                         Group N=            Individual
                                            21                 N= 14


                                          Post-treatment assessment


                         1-year follow-up assessment


                         5-year follow-up assessment

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Effectiveness of CBT for anxiety disorders

  • 1. Effectiveness of CBT for anxiety disorders in mental health clinics and in schools as indicated prevention Bjåstad JF1, Wergeland GJH1,2, Høye, A3, Fjermestad KW1,2, Haugland B1,4, Oeding, K1, Öst LG 1,5, Havik O 1,2, Heiervang ER, 1,6. 1 Anxiety Disorders Research Network, Haukeland University Hospital, Norway 2 University of Bergen, Norway 3 Fjell Municipality, Norway 4 Uni Research, Norway 5 Stockholm University, Sweden 6 University of Oslo, Norway
  • 2. Background • The effect of CBT for childhood anxiety disorders is well documented in university clinic settings • Results may not be valid in regular outpatients clinics – Recruited vs referred children – Homogenous sample – Differences in therapist training • Few effectiveness studies in clinical settings • Few effectiveness studies on the use of CBT as indicative prevention in the school health system
  • 3. Study questions: 1. Is ”FRIENDS for life” effective for the treatment of anxiety for children and adolescents in an outpatient setting? 2. Is ”FRIENDS for life” effective as an indicated prevention program in a school/youth health center setting?
  • 4. Assessment and Treatment- Anxiety in Children and Adults (ATACA) A randomized, controlled, multisite, effectiveness study of the CBT programme ”Friends for life”. PI Einar R. Heiervang, Professor PI Odd E. Havik, Professor Grant from Western Norway Regional Health Trust
  • 5. Study sites No of clinics: 7 No of therapists: 16 No of assessors: 16
  • 6. Methods Participants • 8-15 year olds, ordinary referrals with a primary anxiety disorder diagnosis
  • 7. Methods Inclusion/Exclusion • Inclusion – Separation (SAD), Social (SOP), or Generalised (GAD) anxiety disorder. (ADIS-C/P; CSR>=4) • Exclusion – Autism spectrum disorder – Intellectual disabilities – Obsessive-compulsive disorder – Severe conduct problems – Unstable medication
  • 8. Methods Intervention • Friends for Life, 4th ed (Barrett; 2004, 2005) – Group and Individual format – Child (8-12) and Youth (12-15) versions F - feeling worried ? R - relax and feel good I - inner thoughts E - explore plans N - nice work so reward yourself D - don’t forget to practice S - stay calm, you know how to cope now
  • 9. Methods Measures • Anxiety Disorders Interview Schedule – (ADIS IV-C/P; Silverman & Albano, 1996) • Spence Children’s Anxiety Scale – (SCAS; Spence, 1995) • Short Mood and Feelings Questionnaire – (SMFQ; Angold et al., 1995)
  • 10. Sample characteristics Total sample N=182 M (SD) % Gender Male 47,0 % Female 53,0 % Age (mean, SD) 11.54 (2.08) Age group 8-12 yrs 66,0 % 12-15 yrs 34,0 % Comorbidity present 77,5 % Primary diagnosis SAD 33,0 % SOP 46,0 % GAD 21,0 %
  • 11. Is ”FRIENDS for life” effective for the treatment of anxiety for children and adolescents in an outpatient setting? Results
  • 12. Active treatment vs wait list 80,0 % 70,0 % 60,0 % 50,0 % 43,3 % 40,0 % Post treatment After Wait list 31,1 % 30,0 % 20,0 % 13,9 % 10,0 % 2,8 % 0,0 % No longer primary diagnosis No anxiety diagnosis
  • 13. Group- vs individual treatment 100 % 90 % 80 % 70 % 60 % 50 % 50 % Group 40 % 38 % 38 % Individual 30 % 25 % 20 % 10 % 0% No longer primary diagnosis No anxietydiagnosis
  • 14. Diagnostic Recovery Rates • By age – Children 41% – Adolescents 38% • No statistically significant differences with respect to age group/treatment format an diagnostic recovery rates
  • 15. SCAS and SMFQ • Moderate effect sizes found for – SCAS self-report – SCAS parent report • Moderate effect sizes found for – SMFQ self report – SMFQ parent report • No statistically significant differences between ICBT and GCBT on SCAS and SMFQ
  • 16. Conclusions • CBT is effective in the treatment of anxiety with children and adolescents in ordinary outpatient clinics. • No significant effect found for treatment format post-treatment (group versus individual). • Dropout rate lower than in ordinary outpatient clinics.
  • 17. An early school-based group intervention for youths with anxiety and depression symptoms A study of the CBT programme ”Friends for life”. in Fjell Municipality, Norway
  • 18. Methods Participants • 36 children/ adolescents from 8 schools with anxiety and/or depression symptoms • Ages 8-15 yrs old (M= 11.8) • 12 boys and 24 girls Recruitment • Recruited through contact with the school health-service or psychologist working in the municipality
  • 19. Methods Measures • Spence Children Anxiety Scale; SCAS (Spence,1998). • The Mood & Feelings Questionnarie; MFQ (Costello & Angold, 1988). • The Strength and Difficulties Questionnarie; SDQ (Goodman,1997).
  • 20. Methods Design • Open non-randomization study. • Included 3 months follow up (only child report) Intervention groups • Total of 4 ”FRIENDS for life” groups • 2 in primary school, 1 in secondary school and 1 at a Youth Health Centre.
  • 21. SCAS 40 35 30 SCAS total Score 25 20 Parents 15 Children 10 5 0 Pre Post 3 mnt
  • 22. MFQ 25 20 MFQ total score 15 Parents 10 Children 5 0 Pre Post 3 mnt
  • 23. Conclusions • The “FRIENDS for life” program was effective in reducing anxiety and depression symptoms in this sample • The children and adolescents reported that they liked participating in the groups, and dropout-rate was low (8%). • The school health service can be an important arena for implementing CBT as indicated prevention
  • 24. Implications • ”FRIENDS for life” is effective in regular mental health clinics and as an indicated prevention program in the school health service system.
  • 25. Limitations • Preliminary results • Limited sample size • No follow up
  • 27. Project Group – ATACA study • Einar R. Heiervang, Professor, University of Oslo • Odd E. Havik, Professor, Institute of Clinical Psychology, University of Bergen. • Bente S. Haugland, Dr. Psychol. Centre for Child and Adolescent Metal Health, Western Norway • Kristin Oeding, Cand. Psychol. Institute of Clinical Psychology, University of Bergen • Gerd Kvale, Professor, Institute of Clinical Psychology, University of Bergen. • Jon F. Bjåstad, Doctor of Clinical Psychology, Clinical supervisor • Gro Janne H. Wergeland, Cand. Med., PhD-student, Insitute of Clinical Medicin, University of Bergen. • Krister W. Fjermestad, Cand. Psychol, PhD- student, Institute of Clinical Psychology, University of Bergen. • Lars G. Öst, Professor, Institute of Clinical Psychology, University of Bergen/ Stockholm University. • Robert Goodman, MD PhD, professor, Institute of Psychiatry, King's College London.
  • 28. Timeframe ATACA study: Child part 2007 2008 2010 2015 Clinical trials Main study 182 pts End of 5 year Instruments inclusion included follow-up Pilot Last treatment assessment by 02/2011. 2006 2011 Organization End of 1 year Design follow-up Recruitment assessment
  • 29. Flow Chart Invited N=258 Assessed for eligibility N=222 Enrollment N= 182 Randomisation Group Individual WL N= 38 N=77 N= 67 Assessment and Post-treatment assessment re- randomisation Group N= Individual 21 N= 14 Post-treatment assessment 1-year follow-up assessment 5-year follow-up assessment