The document discusses two scientific articles about factors that can lead to skin cancer and Ewing's sarcoma. The first article discusses how targeting the PTEN protein, which regulates cell growth, may help prevent skin cancer. The second article discusses how ultraviolet light can affect the function of the EWS protein involved in Ewing's sarcoma by changing the expression of genes it regulates and preventing an appropriate DNA damage response. The document emphasizes the importance of DNA repair mechanisms in protecting against UV radiation and preventing disease.

1. Targeting PTEN May Prevent Skin Cancer And Ultraviolet Light Affects Function of Protein Involved in Ewing's Sarcoma. Natalia Zuleta Rendón Medicine Student 3rd Semester

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4. INTRODUCTION NER and repair of mismatches is the principal defense against UV rays These factors may lead to incorrect addition of bases during replication

5. TARGETING PTEN MAY PREVENT SKIN CANCER SCIENCE DAILY (JULY 26, 2011)

6. TARGETING PTEN MAY PREVENT SKIN CANCER Phosphatase and tensin homolog ( PTEN ) is a protein that, in humans, is encoded by the PTEN gene . Regulateof the cell cycle , preventing cells from growing and dividing too rapidly

7. TARGETING PTEN MAY PREVENT SKIN CANCER The degree of inactivation is proportional to the aggressiveness of the disease, that is, the less work the worse the prognosis gene for the patient.

8. TARGETING PTEN MAY PREVENT SKIN CANCER Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue.

9. OBSERVATION With the discovery of this gene could prevent several types of cancer since its action is to prevent cells from multiplying rapidly. Also important to note that if there is a good diet can increase your activity. This gene will be a challenge to modern science as if it can increase its activity was abolished many cancers. (endometrial cancer, prostate and breast)

10. ULTRAVIOLET LIGHT AFFECTS FUNCTION OF PROTEIN IN EWING’S SARCOMA ScienceDaily (August 3, 2011)

11. ULTRAVIOLET LIGHT AFFECTS FUNCTION OF PROTEIN IN EWING’S SARCOMA The genetic circuits altered in cancer processes include the activation or inhibition of various genes and proteins. In the case of Ewing's sarcoma, EWS protein alterations induce changes in the expression of various genes, thus affecting the ability to detect and correct DNA damage.

12. ULTRAVIOLET LIGHT AFFECTS FUNCTION OF PROTEIN IN EWING’S SARCOMA The EWS protein stops being joined to the genes it regulates and relocates to structures located within the cell nucleus known as nucleoli. The relocation results in changes in the expression of the genes regulated by EWS, and these changes are important for an appropriate response to DNA damage.

13. ULTRAVIOLET LIGHT AFFECTS FUNCTION OF PROTEIN IN EWING’S SARCOMA UV radiation can also produce pyrimidine dimers (TT) block transcription which also leads to skin cancer.

14. oBSERVATION The DNA repair mechanisms are the most active response to UV light. Without them we could not expose any type of radiation (solar or conventional light) because it would be fatal for the skin. This study can conclude that these mechanisms should be preserved to prevent many diseases and have a good quality of life.

15. MEDICAL UTILITY

16. Medical utility Through recent advances humanity could prevent and cure many diseases that are deadly and have high prevalence. With the manipulation of genetic material, DNA analysis could know that disease will develop each person and what is the best way to cure them.

17. Medical utility If they are created more consistent treatment to genetic damage, medicine could increase the quality of life of patients, always seeking wellness and cure disease with few adverse effects.

18. Medical utility For medicine is very important to be hand in hand with advances genetic Nothing less eradicated multiple cancers, congenital diseases and diseases caused by bad DNA repair mechanisms.

19. bibliography MARTINEZ S., Lina Maria. Biología Molecular. 6 ed. Medellín: UPB. Facultad de Medicina, 2011. 56 p. CancerResearch (July 26, 2011). Targeting PTEN MayPreventSkinCancer. ScienceDaily. RetrievedAugust 11, 2011, from http://www.sciencedaily.com/releases/2011/07/110726132351.htm Journal Molecular Cell (August 3, 2011). Ultravioler Light AffectsFunction of ProteinInvolved in Ewing’s Sarcoma, StudyFinds. ScienceDaily. RetrievedAugust 11, 2011, from http://www.sciencedaily.com/releases/2011/08/110804133444.htm

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