Angiogenesis

Presented by : Mr. Nirav S. Vachhani M.Pharm Pharmacology (Sem-1) Guided by : Dr. Rina H. Gokani S. J. Thakkar pharmacy college, Rajkot.

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“ Activated” endothelial cells  Proteases Degradation of BM EC migration EC proliferation Lumen formation Recruitment Of pericytes --new BM Fusion – New vessels Initiation of Blood Flow

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[object Object],[object Object],Inhibition of angiogenesis Stimulation of angiogenesis Approved indications Approved indications Advanced cancer Chronic wound-diabetic ulcer Ocular neovascularization Kaposi Sarcoma Experimental indications Experimental indications Hemangiomas Myocardial ischemia Psoriasis Peripheral ischemia Rheumatoid arthritis Cerebral ischemia Endometriosis Reconstructive surgery Atherosclerosis Gastroduodenal ulcers

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Angiogenesis

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Angiogenesis