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Robin Haw!
ORCID!
21st May 2014 "
" " " " " " www.reactome.org "
!
!
!
ORCID identifiers in Reactome!
Ministry of Research !
and Innovation!
What is Reactome?"
•  Open source and open access pathway knowledgebase!
–  1500 human pathways encompassing metabolism, signaling, and other biological
processes.!
–  Biological pathways that describe normal and disease-related events in the human cell.!
–  Every pathway is traceable to primary literature.!
•  Pathway databases like Reactome satisfy common “use cases” in biological and
clinical research:!
–  Intuitive display of biological information.!
–  Visualize multiple experimental data types on a pathway.!
–  Computational methods available to automate analysis.!
•  Collaboration between CSHL, OICR, NYUMC, EBI (not a single institution!)!
Reactome Homepage!
www.reactome.org"
Pathway Browser !
•  Google-map style pathway diagrams !
Details panel"
Pathway diagram"
Pathway hierarchy"
Data Curation Process"
Curator'
(10'Reactome'staff)'
Expert' Reviewer'
•  Pathway modules are expert authored, manually curated and peer-
reviewed.!
–  Recruit bench scientists to write pathway modules.!
–  Curators work with authors to ensure consistency and completeness.!
–  Module checked by peer review and software before publications.!
–  Public Release of Curated data every 3 months.!
–  Regular Pathway updates.!
Reactome-ORCID Project Goals"
•  Stage I: Expand the Reactome data model and database to
support ORCID iDs. !
!!
•  Stage II: Integrate ORCID iD into Reactome software tools
and website.!
•  Stage III: Import and deploy ORCID iD data within
Reactome.!
•  Stage IV: Create documentation, training and outreach.!
Stage I: Expand the Reactome data model and database
to support ORCID iDs !
"•  Updated “Person” class in Reactome database to include cross-reference to ORCID!
All Reactome Curators have ORCID iDs"
Stage II: Integrate ORCID iD into Reactome software
tools and website.!
"
ORCID - Author Attribution"
ORCID - Reviewer Attribution"
Reactome-ORCID Project Status"
•  Stage I: Expand the Reactome data model and database to support
ORCID iDs. !
–  Completed, to deploy June 2014.!
•  Stage II: Integrate ORCID iD into Reactome software tools and
website.!
–  Completed, to deploy June 2014.!
•  Stage III: Import and deploy ORCID iD data within Reactome.!
–  In Progress.!
–  Queried the ORCID registry with the Public API to identify Reactome contributors
with ORCID iDs.!
–  Contacting all previous Reactome contributors.!
–  Author and Review letters now include ORCID information.!
–  Encouraging those with ORCIDs to add Reactome pathways to profile information.!
•  Stage IV: Create documentation, training and outreach.!
–  To start shortly.!
Challenges – Stage II/III"
•  We can’t create ORCID iDs on behalf of individuals.!
–  Reactome is not an institution!!
•  Researchers are reluctant to register.!
–  ~160 authors and ~300 reviewers.!
–  14 contributors with ORCID iDs.!
!
•  How to allow Reactome authors and reviewers to append their
ORCID Record with metadata associated with their Reactome
records? !
–  Reactome is not using the Member API!!
–  Manual updating by contributor!
–  Creating a ‘BibLaTeX’ citation export?!
myORCID page"
Summary "
•  Our open access and open source policies make this an
attractive open data linkage between the scientist and pathway
knowledge via the ORCID iD. !
•  ORCID iDs as a key mechanism for credit attribution for
Reactome.!
•  A valuable route to increase visibility of the contributions of our
external domain experts (authors and reviewers) and curators. !
•  We are keen to resolve the systemic naming ambiguity by
implementing the ORCID.!
•  A great potential for other bioinformatics resources to adopt
ORCID since they are also reliant on expert contributions and/
or curators.!
Acknowledgements"
•  Michael Caudy !!
•  David Croft!
•  Eric Dawson!
•  Adrian Duong!
•  Phani Garapati!
•  Marc Gillespie!
•  Bijay Jassal !!
•  Steve Jupe!
•  Irina Kalatskaya!
•  Maulik Kamdar!
•  Bruce May!
•  Sheldon MacKay!
•  Lisa Matthews!
•  Antonio Fabregat Mundo!
•  Marija Orlic-Milacic!
•  Karen Rothfels!
•  Veronica Shamovsky!
•  Heeyeon Song!
•  Joel Weiser !!
•  Mark Williams!
•  Guanming Wu!
•  ChristinaYung!
•  Henning Hermjakob"
•  Peter D’Eustachio"
•  Lincoln Stein"
Ministry of Research and
Innovation!
Demo"

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ORCID Identifiers in Reactome

  • 1. Robin Haw! ORCID! 21st May 2014 " " " " " " " www.reactome.org " ! ! ! ORCID identifiers in Reactome! Ministry of Research ! and Innovation!
  • 2. What is Reactome?" •  Open source and open access pathway knowledgebase! –  1500 human pathways encompassing metabolism, signaling, and other biological processes.! –  Biological pathways that describe normal and disease-related events in the human cell.! –  Every pathway is traceable to primary literature.! •  Pathway databases like Reactome satisfy common “use cases” in biological and clinical research:! –  Intuitive display of biological information.! –  Visualize multiple experimental data types on a pathway.! –  Computational methods available to automate analysis.! •  Collaboration between CSHL, OICR, NYUMC, EBI (not a single institution!)!
  • 4. Pathway Browser ! •  Google-map style pathway diagrams ! Details panel" Pathway diagram" Pathway hierarchy"
  • 5. Data Curation Process" Curator' (10'Reactome'staff)' Expert' Reviewer' •  Pathway modules are expert authored, manually curated and peer- reviewed.! –  Recruit bench scientists to write pathway modules.! –  Curators work with authors to ensure consistency and completeness.! –  Module checked by peer review and software before publications.! –  Public Release of Curated data every 3 months.! –  Regular Pathway updates.!
  • 6. Reactome-ORCID Project Goals" •  Stage I: Expand the Reactome data model and database to support ORCID iDs. ! !! •  Stage II: Integrate ORCID iD into Reactome software tools and website.! •  Stage III: Import and deploy ORCID iD data within Reactome.! •  Stage IV: Create documentation, training and outreach.!
  • 7. Stage I: Expand the Reactome data model and database to support ORCID iDs ! "•  Updated “Person” class in Reactome database to include cross-reference to ORCID!
  • 8. All Reactome Curators have ORCID iDs"
  • 9. Stage II: Integrate ORCID iD into Reactome software tools and website.! "
  • 10. ORCID - Author Attribution"
  • 11. ORCID - Reviewer Attribution"
  • 12. Reactome-ORCID Project Status" •  Stage I: Expand the Reactome data model and database to support ORCID iDs. ! –  Completed, to deploy June 2014.! •  Stage II: Integrate ORCID iD into Reactome software tools and website.! –  Completed, to deploy June 2014.! •  Stage III: Import and deploy ORCID iD data within Reactome.! –  In Progress.! –  Queried the ORCID registry with the Public API to identify Reactome contributors with ORCID iDs.! –  Contacting all previous Reactome contributors.! –  Author and Review letters now include ORCID information.! –  Encouraging those with ORCIDs to add Reactome pathways to profile information.! •  Stage IV: Create documentation, training and outreach.! –  To start shortly.!
  • 13. Challenges – Stage II/III" •  We can’t create ORCID iDs on behalf of individuals.! –  Reactome is not an institution!! •  Researchers are reluctant to register.! –  ~160 authors and ~300 reviewers.! –  14 contributors with ORCID iDs.! ! •  How to allow Reactome authors and reviewers to append their ORCID Record with metadata associated with their Reactome records? ! –  Reactome is not using the Member API!! –  Manual updating by contributor! –  Creating a ‘BibLaTeX’ citation export?!
  • 15. Summary " •  Our open access and open source policies make this an attractive open data linkage between the scientist and pathway knowledge via the ORCID iD. ! •  ORCID iDs as a key mechanism for credit attribution for Reactome.! •  A valuable route to increase visibility of the contributions of our external domain experts (authors and reviewers) and curators. ! •  We are keen to resolve the systemic naming ambiguity by implementing the ORCID.! •  A great potential for other bioinformatics resources to adopt ORCID since they are also reliant on expert contributions and/ or curators.!
  • 16. Acknowledgements" •  Michael Caudy !! •  David Croft! •  Eric Dawson! •  Adrian Duong! •  Phani Garapati! •  Marc Gillespie! •  Bijay Jassal !! •  Steve Jupe! •  Irina Kalatskaya! •  Maulik Kamdar! •  Bruce May! •  Sheldon MacKay! •  Lisa Matthews! •  Antonio Fabregat Mundo! •  Marija Orlic-Milacic! •  Karen Rothfels! •  Veronica Shamovsky! •  Heeyeon Song! •  Joel Weiser !! •  Mark Williams! •  Guanming Wu! •  ChristinaYung! •  Henning Hermjakob" •  Peter D’Eustachio" •  Lincoln Stein" Ministry of Research and Innovation!
  • 17. Demo"