3. Dedication
This presentation is dedicated to all
Cancer patients across the globe and
may our efforts, towards research in
this area benefit those who are
fighting the dangerous disease
13. Colchium speciosum
Family: Liliaceae
Drugs: Colchicine
Mode of action in cancer:
1. Breast cancer
2. Thyroid cancer
3. Oesophageal cancer
PPRC/INDIA 10
33. Dictamnus dasycarpus
Active principle: Limonoid triterpene enhances
cytotoxicity to microtubules suggesting the
action site may be extract of Barringtonia
racemosa
Anti-tumour activity against Dalton’s
Lymphoma Ascitis (DLA) in mice
Ref: Thomas et. al. 2002
PPRC/INDIA 30
35. Brassica oleracea
Administration of allyl isothiocyanate (AITC)
a naturally occurring Sulphur compound
along with Cyclophosphamide (CYP)
induced Urotoxicity, where glutathione in
bladder and liver enhanced and also showed
normal bladder morphology
PPRC/INDIA 32
37. Punica granatum
The fruit rind powder elicited an increase in
antibody titre, inhibited leukocyte migration
and delayed hypersensitivity reaction
confirming its stimulatory effect on humoral
and cell mediated components of the
immune system in rabbits
Ref: Gracious et. al. 2001
PPRC/INDIA 34
43. Silybum marianum
Active principle: Silymarin
A plant flavanolignan mixture isolated from
the seeds
Possesses antioxidant, anti-inflammatory,
immuno-modulatory properties leading to
prevention of different cancers
PPRC/INDIA 40
47. Lycopene in Tomatoes
Lycopene, the major carotenoid in tomatoes
is a protective compound against Prostate
cancer
It affects Stomach, Colon, Oral, Lung and
Breast cancer
Protects mice from bacterial infections and
inhibits growth of Ascites tumours
PPRC/INDIA 44
48. Lycopene in Tomatoes
Affects glioma cells
Suppresses orthotopic growth of human
prostate tumours
Lycopene inhibits proliferation of Lung
cancer – Levy et. al. 1995
Inhibits the growth of Leukaemia and
malignant tumours
PPRC/INDIA 45
51. Capsaicin
Family: Solanaceae
Capsaicin, active principle in hot red and
chilli, peppers
Widely used as spices
Dual role in carcinogenic and mutagenic
processes
PPRC/INDIA 48
52. Capsaicin
Protective effect on stomach cancer
Affects metabolism of carcinogens
Represses the growth of Hela, Ovarian
carcinoma, mammary adeno-carcinoma and
P. leukaemia, HL 60 cells
PPRC/INDIA 49
58. Tabebuia avellanedae
Extract from stem bark showed anti-tumour
activity
Nowadays T. avellanedae extract is
commercialized as a miracle drug in the
treatment of cancer and other health
problems in Japan – Nakamura 2000
PPRC/INDIA 55
59. Tabebuia avellanedae
Components from this extract:
1. Naphtho-quinone lapachol
2. Beta-lapachone
showed strong anti-neoplastic properties
PPRC/INDIA 56