1. DR MOHD SHAHID
DEPARTMENT OF MOLAJAT
NIUM, BANGALORE

2.  BMC Complementary and Alternative Medicine is an
open access, peer-reviewed journal that considers
articles on interventions and resources that complement
or replace conventional therapies, with a specific
emphasis on research that explores the biological
mechanisms of action, as well as their
efficacy, safety, costs, patterns of use and/or
implementation
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 ISSN: 1472-6882

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6. Received: 16 Nov 2012
Accepted: 01 Nov 2013
Published: 13 Nov 2013

7.  A randomized, controlled
cross-over trial of dermally-
applied lavender (Lavandula
angustifolia) oil as a
treatment of agitated
behaviour in dementia

8.  Informative ?
 Self Explanatory ?
 Variables are Specific ?

9.  Daniel W O’Connor*
 Barbara Eppingstall
 John Taffe
 Eva S van der Ploeg
 *Correspondence: Daniel.OConnor@monash.edu
School of Psychology and Psychiatry, Monash
University, Kingston Centre, Warrigal
Road, Cheltenham, Victoria 3192, Australia

10. Competent ?
Degree and Designations ?
E mail is mentioned

11.  A progressive, irreversible decline in mental
function, marked by memory impairment
and, often, deficits in reasoning, judgment, abstract
thought, registration, comprehension, learning, task
execution, and use of language
 In the U.S., 4.5 million people are afflicted by
dementia. The prevalence is esp. high in the very
elderly: about 20% to 40% of those over 85 are
demented
 Dementia is somewhat more common in women than in
men

12.  Synonym L.
officinalis Chaix. L.
spica Linn.
 Family Labiatae;
Lamiaceae.
 Habitat Native to
Mediterranean
region; cultivated in
Jammu and Kashmir
 English name:
Lavender

13.  Action Herb—mildly sedative, antiflatulent and
cholagogue. Essential oil—
antiseptic, antibacterial, antispasmodic.
 Major constituents of the essential oil are linalool and
linalyl acetate.

14.  Family Papilionaceae;
Fabaceae.
 Habitat
Mediterranean region
and Asia Minor. Dried
plant and flowers are
imported into Mumbai
from Persian Gulf
 English Arabian or
French: Lavender
 Unani:
Ustukhuddus, Alfaajan
 Folk: Dhaaru

15.  Action Flowers—
antidepressive, sedative, anticonvulsant, carminative, a
ntispasmodic, antibacterial, antiseptic. Used in
depression, nervous headache, sluggish
circulation, physical and mental
exhaustion, insomnia, epilepsy, neuralgia and
rheumatic affections
 Plant—used for the treatment of epilepsy and chronic
sinusitis in Unani medicine.

16.  BACKGROUND clearly mentioned
 Objective is clearly stated (want to know efficacy of
test drug )
 It is a Randomized, single blind cross-over
trial, mentioned in abstract
 Study design is also given in abstract
 Hypothesis is declare
 Results also mentioned clearly that test drug is not
significant against the conrol drug
 Trial registration also stated (ACTRN)

17.  Conclusion is comprehensible
 Within the word limit
 Purpose of study is well defined

18. Within word limits
Appropriate

19.  Prevalence missing of dementia
 More emphasis on Lavender
 Wonderfully describe why they choose test drug
with proper references.
 One study quted, that describe the efficacy is
equal to lorazepam0.5 mg
 Literature review provided
 Aim of study is mentioned
 Astonishingly discussed about previous study

20.  Need of study is mentioned
 Purpose of study is mentioned but why they choose
fore arm massage instead of head or any other part
of the body, not declared

21.  Palace of study point out, and also from where the
participants enrolled (8 specialist Psychogeriatric
nursing home and 3 private nursing home in
Melbourne)
 Diagnostic criteria is declare, with REFERENCE
(CLINICAL DEMENTIA RATING SCALE)
 Inclusion & Exclusion criteria Stated
 Test drug & dosage are mentioned properly, WHY
THIS DRUG---- REFERENCES given
 Duration of study mentioned between 2009 and 2011)

22.  Study protocol approved by IEC
 Test drug choose after electrophysical analysis in
Department of Pharmacology and Toxicology, Otago
University, New Zealand
 Not describe the control drug (just
stated neutral control oil)
 Follow up & total number of patient screened declared
 Drop outs declared, with REASONS
 Randomization done through
Exel random number generator

23.  Duration of protocol is also declared, that is both
intervention comprised 3 exposures over a one week
with 4 days washout period and the trial was limited to
2 week
 Sample size declared
 Group A: total allocated patients 38, number of patients
complete the intervention are 37
 Group B ; total allocated patients 28, number of
patients complete the intervention are 27
 Written consent was taken from the next of Kin or legal
guardians
 Study design mentioned

24.  Subjective and Objective criteria point out
 Tables are clearly defined, with Graphical
representation
 Analysis are made through
1. Two sided hypothesis test with Type I error rate 0.05
and power set to 90
2. Binomial regression test

25.  Discussion about the result are justified
 Mention the limitation of study
1. Product varialbility
2. Limited knowledge base of lavender’s
pharmacological properties
3. Dosing strategies are based largely on traditional
practice

26.  Unambiguously declare that Studies of essential oils
are constrained by their variable formulations and
uncertain pharmacokinetics and so optimal dosing
and delivery regimens remain speculative.
 However this, topically delivered, high strength, pure
lavender oil had no discernible effect on affect and
behaviour in a well-defined clinical sample.

27.  Acknowledgements are declare
 Funding: By National Health and Medical Research
Council and the Dementia Collaborative Reasearch
Centre administered through the University of New
South Wales. Neither funding body, nor the supplier of
materials, played any part in analysing data and
preparing this report.
 Reference according to the journal guidelines

28.  This is wonderful example that how to done and write a
standard paper
 For me, this is the way to approach a study before
going to conduct it
 They have given every answers before you raise any
question
 Wonderful paper

29. Always welcome at
drshahidkhan2005@gmail.com
Thanks for your
patience

30. Open For Discussion