Latest Advances in Clinical Senology and Oncology

1. Senology Newsletter Page 1 of 3
Senology.org - Newsletter
International Senologic and Oncologic Scientific Community (ISOSC)
"Connecting specialists worldwide"
February 7, 2013
Editor-in-Chief: Gian Paolo Andreoletti, MD
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Literature Selection
Girshik J et al.: "Self-reported Sleep Duration, Sleep Quality, and Breast Cancer Risk in a Population-
based Case-Control Study", Am J Epidemiol. 2013 Jan 16. [Epub ahead of print]
Kim JY et al.: "Unilateral Breast Cancer: Screening of Contralateral Breast by Using Preoperative MR
Imaging Reduces Incidence of Metachronous Cancer", Radiology. 2013 Jan 17. [Epub ahead of print]
Kloten V et al.: "Promoter hypermethylation of the tumor suppressor genes ITIH5, DKK3, and
RASSF1A as novel biomarkers for blood-based breast cancer screening", Breast Cancer Res. 2013
Jan 15;15(1):R4. [Epub ahead of print]
Hou G et al.: "Clinical pathological characteristics and prognostic analysis of 1,013 breast cancer
patients with diabetes", Breast Cancer Res Treat. 2013 Feb;137(3):807-16
Marinovich ML et al.: "Meta-analysis of Magnetic Resonance Imaging in Detecting Residual Breast
Cancer After Neoadjuvant Therapy", J Natl Cancer Inst. 2013 Jan 7. [Epub ahead of print]
Yoshinaga Y et al.: "Image and pathological changes after radiofrequency ablation of invasive breast
cancer: a pilot study of nonsurgical therapy of early breast cancer", World J Surg. 2013 Feb;37(2):356-
63
Hwang ES et al.: "Survival after lumpectomy and mastectomy for early stage invasive breast cancer:
The effect of age and hormone receptor status", Cancer. 2013 Jan 28 [Epub ahead of print]
Lang JE et al.: "Primary Tumor Extirpation in Breast Cancer Patients Who Present with Stage IV
Disease is Associated with Improved Survival", Ann Surg Oncol. 2013 Jan 11. [Epub ahead of print]
Freedman GM et al.: "Accelerated fractionation with a concurrent boost for early stage breast cancer",
Radiother Oncol. 2013 Jan 16 [Epub ahead of print]
Loi S et al.: "Prognostic and Predictive Value of Tumor-Infiltrating Lymphocytes in a Phase III
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2. Senology Newsletter Page 2 of 3
Randomized Adjuvant Breast Cancer Trial in Node-Positive Breast Cancer Comparing the Addition of
Docetaxel to Doxorubicin With Doxorubicin-Based Chemotherapy: BIG 02-98", J Clin Oncol. 2013 Jan
22. [Epub ahead of print]
Sapkota Y et al.: "Germline DNA copy number aberrations identified as potential prognostic factors
for breast cancer recurrence", PLoS One. 2013;8(1):e53850 Epub 2013 Jan 16. Free full text article in
PubMed Central
Discussion
- Article in the British Medical Journal (BMJ 2013;346:f385): "Harms from breast cancer screening
outweigh benefits if death caused by treatment is included" - Share your opinion on LinkedIn
Calendar of Events
13th St. Gallen International Breast Cancer Conference, March 13-16, 2013, St. Gallen, Switzerland
5th IMPAKT Breast Cancer Conference, May 2-4, 2013, Brussels, Belgium
FOCUS ON - Improving Breast Cancer Detection on MRI - in collaboration with
Bracco Imaging
"MRI is widely considered the best diagnostic imaging modality for the detection and
characterization of breast cancer. However optimal diagnostic performance on
breast MRI depends not only on selection of the most appropriate MR image
acquisition parameters but also on optimized contrast enhancement for both the
detection of breast lesions and their accurate characterization as cancerous. .In a
paper published in Radiology, Martincich et al highlighted the importance of contrast
agent relaxivity in improving malignant lesion detection and diagnostic performance
on breast MRI. In an intra-individual crossover study in which ... (read more)"
Literature Selection
Vollset SE et al.: "Effects of folic acid supplementation on overall and site-specific cancer incidence
during the randomised trials: meta-analyses of data on 50 000 individuals", Lancet. 2013 Jan 24 [Epub
ahead of print]
Qin X et al.: "Folic acid supplementation and cancer risk: A meta-analysis of randomized controlled
trials", Int J Cancer. 2013 Jan 22 [Epub ahead of print]
Wong GL et al.: "Meta-analysis: the association of hepatitis B virus genotypes and hepatocellular
carcinoma", Aliment Pharmacol Ther. 2013 Jan 10 [Epub ahead of print]
Wang JH et al.: "Hepatocellular Carcinoma Surveillance at 4- vs. 12-Month Intervals for Patients With
Chronic Viral Hepatitis: A Randomized Study in Community", Am J Gastroenterol. 2013 Jan 15 [Epub
ahead of print]
Koh WP et al.: "Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore
Chinese Health Study", Br J Cancer. 2013 Jan 31 [Epub ahead of print]
Vinogradova Y et al.: "Exposure to bisphosphonates and risk of gastrointestinal cancers: series of
nested case-control studies with QResearch and CPRD data", BMJ. 2013 Jan 16;346:f114. Free full
text article in PubMed Central
Cui L et al.: "Gastric juice MicroRNAs as potential biomarkers for the screening of gastric cancer",
Med Oncol. 2013 Mar;30(1):365
Singh A et al.: "Many patients who undergo surgery for colorectal cancer receive surveillance
colonoscopies earlier than recommended by guidelines", Clin Gastroenterol Hepatol. 2013 Jan;11
(1):65-72.e1
Resnick MJ et al.: "Long-term functional outcomes after treatment for localized prostate cancer", N
Engl J Med. 2013 Jan 31;368(5):436-45
Editorial
"Higher serum calcium levels may be a biomarker of ovarian cancer", Gary Schwartz, Wake Forest
School of Medicine, Winston-Salem, NC, USA
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3. Senology Newsletter Page 3 of 3
"The take-home message from our paper is that there is a pressing need for markers of ovarian cancer that
could detect the disease at an early, curable stage, much like a smoke-detector can detect a small fire before
it is impossible to contain. Our findings that serum calcium levels that are high, but not yet abnormal (high
normo-calcemia) predicted both incident and fatal ovarian cancer suggest that high serum calcium could
identify women with subclinical ovarian cancer, potentially leading to a diagnosis before the disease became
clinically apparent".
(Commentary on: Schwartz GG et al.: "Prospective studies of total and ionized serum calcium in
relation to incident and fatal ovarian cancer", Gynecol Oncol. 2013 Jan 9 [Epub ahead of print])
Questions and Answers
Lung Cancer Workshop Summary - with Suresh Ramalingam, Emory University, Atlanta, GA, USA
Lung Cancer Workshop Summary - with Nathan Pennell, Taussig Cancer Center, Cleveland Clinic,
Cleveland, OH, USA
Colorectal Cancer Workshop Summary - with Jeffrey Farma, Fox Chase Cancer Center, Philadelphia, PA,
USA
Prostate Cancer Workshop Summary - with Bruce Roth, Washington University, St. Louis, MO, USA
Cancer Chemoprevention Workshop Summary - with Yuesheng Zhang, Roswell Park Cancer Institute,
Buffalo, NY, USA
Literature Selection
Lin WT et al.: "Comparison of age at natural menopause in BRCA1/2 mutation carriers with a non-
clinic-based sample of women in northern California", Cancer. 2013 Jan 29 [Epub ahead of print]
Brinton LA et al.: "In vitro fertilization and risk of breast and gynecologic cancers: a retrospective
cohort study within the Israeli Maccabi Healthcare Services", Fertil Steril. 2013 Jan 29 [Epub ahead of
print]
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