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The Nazi Human Experimentation

                                                                         over 1,500 sets of imprisoned
                                                                         twins, of which fewer than 200
Nazi human experimentation was a series of controversial                 individuals survived the studies.
medical experiments on large numbers of prisoners by the                 Whilst attending University of
German Nazi regime in its concentration camps during World               Munich (located in the city that
                                                                         remained one of Adolf Hitler’s
War II. Prisoners were coerced into participating: they did not
                                                                         focal    points    during    the
willingly volunteer and there was never informed consent.
                                                                         revolution) studying philosophy
Typically, the experiments resulted in death, disfigurement or           and medicine with an emphasis
permanent disability                                                     on       anthropology        and
                                                                         paleontology, Mengele got
                                                                         swept up in the Nazi hysteria
                                                             and even said that “this simple political
                                                             concept finally became the decisive factor
         At Auschwitz and other camps, under the             in my life”. Mengele’s newfound
         direction of Dr. Eduard Wirths, selected            admiration for the “simple political
         inmates were subjected to various                   concept” led him to mix his studies of
         experiments which were supposedly                   medicine and politics as his career choice.
         designed to help German military
         personnel in combat situations, develop             Mengele received his PhD for a thesis
         new weapons, aid in the recovery of                 entitled “Racial Morphological Research
         military personnel that had been injured,           on the Lower Jaw Section of Four Racial
         and to advance the racial ideology backed           Groups”, which suggested that a person’s
         by the Third Reich. After the war, these            race could be identified by the shape of the
         crimes were tried at what became known              jaw. The Nazi organization saw his studies
         as the Doctors’ Trial, and revulsion at the         as talents, and Mengele was asked to be
         abuses perpetrated led to the development           the leading physician and researcher at
         of the Nuremberg Code of medical ethics.            Auschwitz concentration camp in Poland
                                                             in May 1943. There, Mengele organized
         According to the indictment at the                  genetic experiments on twins. The twins
         Subsequent Nuremberg Trials, these                  were arranged by age and sex and kept in
         experiments included the following:                 barracks between experiments, which
                                                             ranged from injection of different
         Experiments on twins                                chemicals into the eyes of twins to see
                                                             whether it would change their colors to
                                                             literally sewing twins together to try
                                                             creating conjoined twins.

                                                            Freezing experiments



                                   Experiments on
        twin children in concentration camps were
        created to show the similarities and
        differences in the genetics and eugenics of                                 A cold water
        twins, as well as to see if the human body          immersion     experiment    at    Dachau
        can be unnaturally manipulated. The                 concentration camp presided over by
        central leader of the experiments was Josef         Professor Ernst Holzlohner (left) and Dr.
        Mengele, who performed experiments on


                                                                              http://www.myclinicalresearchbook.blogspot.com/
Sigmund Rascher (right). The subject is        Malaria experiments
wearing a Luftwaffe garment.

In 1941, the Luftwaffe conducted
experiments to learn how to treat
hypothermia. One study forced subjects to
endure a tank of ice water for up to three
hours. Another study placed prisoners
naked in the open for several hours with                                        From about
temperatures    below    freezing.    The      February 1942 to about April 1945,
experimenters assessed different ways of       experiments were conducted at the Dachau
rewarming survivors.                           concentration camp in order to investigate
                                               immunization for treatment of malaria.
The freezing/hypothermia experiments           Healthy inmates were infected by
were conducted for the Nazi high               mosquitoes or by injections of extracts of
command.       The      experiments were       the mucous glands of female mosquitoes.
conducted on men to simulate the               After contracting the disease, the subjects
conditions the armies suffered on the          were treated with various drugs to test
Eastern Front, as the German forces were       their relative efficiency. Over 1,000 people
ill prepared for the bitter cold.              were used in these experiments, and of
                                               those, more than half died as a result.
The experiments were conducted under the
supervision of Dachau and Auschwitz.           Mustard gas experiments
Rascher reported directly to Heinrich
Himmler, and publicised the results of his
freezing experiments at the 1942 medical
conference entitled “Medical Problems
Arising from Sea and Winter”.

The freezing experiments were in two
parts. First, to establish how long it would
take to lower the body temperature to                                    At various times
death, and second how to best resuscitate      between September 1939 and April 1945,
the frozen victim.                             experiments      were      conducted     at
                                               Sachsenhausen, Natzweiler, and other
The icy vat method proved to be the fastest    camps to investigate the most effective
way to drop the body temperature. The          treatment of wounds caused by mustard
selections were made of young healthy          gas. Test subjects were deliberately
Jews or Russians. They were usually            exposed to mustard gas and other
stripped naked and prepared for the            vesicants, which inflicted severe chemical
experiment. An insulated probe which           burns. The victims’ wounds were then
measured the drop in the body temperature      tested to find the most effective treatment
was inserted into the rectum. The probe        for the mustard gas burns.
was held in place by an expandable metal
ring which was adjusted to open inside the     Sulfonamide experiments
rectum to hold the probe firmly in place.
The victim was put into an air force           From about July 1942 to about September
uniform, then placed in the vat of cold        1943, experiments to investigate the
water and started to freeze.                   effectiveness of sulfonamide, a synthetic
                                               antimicrobial agent, were conducted at


                                                                http://www.myclinicalresearchbook.blogspot.com/
Ravensbrück. Wounds inflicted on the           of people with a minimum of time and
subjects were infected with bacteria such      effort. These experiments were conducted
as Streptococcus, gas gangrene and             by means of X-ray, surgery and various
                                               drugs. Thousands of victims were
                                               sterilized. Aside from its experimentation,
                                               the Nazi government sterilized around
                                               400,000 individuals as part of its
                                               compulsory        sterilization    program.
                                               Intravenous injections of solutions
                                               speculated to contain iodine and silver
tetanus.
                                               nitrate           were           successful,
Circulation of blood was interrupted by
tying off blood vessels at both ends of the
wound to create a condition similar to that
of a battlefield wound. Infection was
aggravated by forcing wood shavings and
ground glass into the wounds. The
infection was treated with sulfonamide and
other    drugs     to    determine    their
effectiveness.                                                       but had unwanted
                                               side effects such as vaginal bleeding,
Sea water experiments                          severe abdominal pain, and cervical
                                               cancer. Therefore, radiation treatment
                                               became the favored choice of sterilization.
                                               Specific amounts of exposure to radiation
                                               destroyed a person’s ability to produce ova
                                               or sperm. The radiation was administered
                                               through deception. Prisoners were brought
                              From about       into a room and asked to complete forms,
July 1944 to about September 1944,             which took two to three minutes. In this
experiments were conducted at the Dachau       time, the radiation treatment was
concentration camp to study various            administered and, unknown to the
methods of making sea water drinkable. At      prisoners, they were rendered completely
one point, a group of roughly 90 Roma          sterile. Many suffered severe radiation
were deprived of food and given nothing        burns.
but sea water to drink by Dr. Hans
Eppinger, leaving them gravely injured.        Experiments with poison
They were so dehydrated that others
observed them licking freshly mopped           In or around December 1943 and October
floors in an attempt to get drinkable water.   1944, experiments were conducted at
                                               Buchenwald to investigate the effect of
Sterilization experiments                      various poisons. The poisons were secretly
                                               administered to experimental subjects in
From about March 1941 to about January         their food. The victims died as a result of
1945, sterilization experiments were           the poison or were killed immediately in
conducted at Auschwitz, Ravensbrück, and       order to permit autopsies. In September
other places by Dr. Carl Clauberg. The         1944, experimental subjects were shot with
purpose of these experiments was to            poisonous bullets, suffered torture and
develop a method of sterilization which        often died.
would be suitable for sterilizing millions


                                                                http://www.myclinicalresearchbook.blogspot.com/
Incendiary bomb experiments                    the trial, several of the doctors argued in
                                               their defense that there was no
From around November 1943 through to           international law regarding medical
circa January 1944, experiments were           experimentation.
conducted at Buchenwald to test the effect
of various pharmaceutical preparations on      However, informed consent in German
phosphorus burns. These burns were             medicine was not original to issues
inflicted on prisoners using phosphorus        surrounding WWII. In 1900, Dr. Albert
material extracted from incendiary bombs.      Neisser     infected   patients    (mainly
                                               prostitutes) with syphilis without their
High altitude experiments                      consent. Despite support from most of the
                                               academic community, public opinion was
                                               against Neisser, led by psychiatrist Albert
                                               Moll. While Neisser went on to be fined
                                               by the Royal Disciplinary Court, Moll
                                               developed “a legally based, positivistic
                                               contract theory of the patient-doctor
                                               relationship” that was not adopted into
                                               German law.

                                               Eventually, the minister for religious,
                                               educational, and medical affairs issued a
                                               directive stating that medical interventions
                             In early 1942,    other than for diagnosis, healing, and
prisoners at Dachau concentration camp         immunization were excluded under all
were used by Rascher in experiments to         circumstances if “the human subject was a
aid German pilots who had to eject at high     minor or not competent for other reasons”
altitudes. A low-pressure chamber              or if the subject had not given his or her
containing these prisoners was used to         “unambiguous consent” after a “proper
simulate conditions at altitudes of up to 20   explanation of the possible negative
km (66,000 ft). It was rumored that            consequences” of the intervention.
Rascher performed vivisections on the          However, this was not legally binding.
brains of victims who survived the initial
experiment.[20] Of the 200 subjects, 80
                                               In response, Drs. Leo Alexander and
died outright, and the others were
                                               Andrew Conway Ivy drafted a ten point
executed. (See also Hubertus Strughold.)
                                               memorandum entitled Permissible Medical
                                               Experiment that went on to be known as
Aftermath                                      the Nuremberg Code. The code calls for
                                               such standards as voluntary consent of
Many of the subjects died as a result of the   patients, avoidance of unnecessary pain
experiments conducted by the Nazis, while      and suffering, and that there must be a
many others were murdered after the tests      belief that the experimentation will not end
were completed or to study the effect post     in death or disability. However, the Code
mortem. Those who survived were often          was not cited in any of the findings against
left mutilated, suffering permanent            the defendants and never made it into
disability, weakened bodies, and mental        either German or American medical law.
duress. On August 19, 1947, the doctors
captured by Allied forces were put on trial
in USA vs. Karl Brandt et al., which is
commonly known as the Doctors’ Trial. At



                                                                http://www.myclinicalresearchbook.blogspot.com/
Modern ethical issues

The modern body of medical knowledge
about how the human body reacts to
freezing to the point of death is based
almost exclusively on these Nazi
experiments. This, together with the recent
use of data from Nazi research into the
effects of phosgene gas, has proved
controversial and presents an ethical
dilemma for modern physicians who do
not agree with the methods used to obtain
these data. Similarly, controversy has
arisen from the use of results of biological
warfare testing done by the Imperial
Japanese Army’s Unit 731. However, the
results from Unit 731 were kept classified
by the United States and the majority of
doctors involved were given pardons.
i




i
Taken from:-
www.wikipedia.org/wiki/Nazi_human_experiment
ation




                                               http://www.myclinicalresearchbook.blogspot.com/

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The Nazi Human Expermentation

  • 1. The Nazi Human Experimentation over 1,500 sets of imprisoned twins, of which fewer than 200 Nazi human experimentation was a series of controversial individuals survived the studies. medical experiments on large numbers of prisoners by the Whilst attending University of German Nazi regime in its concentration camps during World Munich (located in the city that remained one of Adolf Hitler’s War II. Prisoners were coerced into participating: they did not focal points during the willingly volunteer and there was never informed consent. revolution) studying philosophy Typically, the experiments resulted in death, disfigurement or and medicine with an emphasis permanent disability on anthropology and paleontology, Mengele got swept up in the Nazi hysteria and even said that “this simple political concept finally became the decisive factor At Auschwitz and other camps, under the in my life”. Mengele’s newfound direction of Dr. Eduard Wirths, selected admiration for the “simple political inmates were subjected to various concept” led him to mix his studies of experiments which were supposedly medicine and politics as his career choice. designed to help German military personnel in combat situations, develop Mengele received his PhD for a thesis new weapons, aid in the recovery of entitled “Racial Morphological Research military personnel that had been injured, on the Lower Jaw Section of Four Racial and to advance the racial ideology backed Groups”, which suggested that a person’s by the Third Reich. After the war, these race could be identified by the shape of the crimes were tried at what became known jaw. The Nazi organization saw his studies as the Doctors’ Trial, and revulsion at the as talents, and Mengele was asked to be abuses perpetrated led to the development the leading physician and researcher at of the Nuremberg Code of medical ethics. Auschwitz concentration camp in Poland in May 1943. There, Mengele organized According to the indictment at the genetic experiments on twins. The twins Subsequent Nuremberg Trials, these were arranged by age and sex and kept in experiments included the following: barracks between experiments, which ranged from injection of different Experiments on twins chemicals into the eyes of twins to see whether it would change their colors to literally sewing twins together to try creating conjoined twins. Freezing experiments Experiments on twin children in concentration camps were created to show the similarities and differences in the genetics and eugenics of A cold water twins, as well as to see if the human body immersion experiment at Dachau can be unnaturally manipulated. The concentration camp presided over by central leader of the experiments was Josef Professor Ernst Holzlohner (left) and Dr. Mengele, who performed experiments on http://www.myclinicalresearchbook.blogspot.com/
  • 2. Sigmund Rascher (right). The subject is Malaria experiments wearing a Luftwaffe garment. In 1941, the Luftwaffe conducted experiments to learn how to treat hypothermia. One study forced subjects to endure a tank of ice water for up to three hours. Another study placed prisoners naked in the open for several hours with From about temperatures below freezing. The February 1942 to about April 1945, experimenters assessed different ways of experiments were conducted at the Dachau rewarming survivors. concentration camp in order to investigate immunization for treatment of malaria. The freezing/hypothermia experiments Healthy inmates were infected by were conducted for the Nazi high mosquitoes or by injections of extracts of command. The experiments were the mucous glands of female mosquitoes. conducted on men to simulate the After contracting the disease, the subjects conditions the armies suffered on the were treated with various drugs to test Eastern Front, as the German forces were their relative efficiency. Over 1,000 people ill prepared for the bitter cold. were used in these experiments, and of those, more than half died as a result. The experiments were conducted under the supervision of Dachau and Auschwitz. Mustard gas experiments Rascher reported directly to Heinrich Himmler, and publicised the results of his freezing experiments at the 1942 medical conference entitled “Medical Problems Arising from Sea and Winter”. The freezing experiments were in two parts. First, to establish how long it would take to lower the body temperature to At various times death, and second how to best resuscitate between September 1939 and April 1945, the frozen victim. experiments were conducted at Sachsenhausen, Natzweiler, and other The icy vat method proved to be the fastest camps to investigate the most effective way to drop the body temperature. The treatment of wounds caused by mustard selections were made of young healthy gas. Test subjects were deliberately Jews or Russians. They were usually exposed to mustard gas and other stripped naked and prepared for the vesicants, which inflicted severe chemical experiment. An insulated probe which burns. The victims’ wounds were then measured the drop in the body temperature tested to find the most effective treatment was inserted into the rectum. The probe for the mustard gas burns. was held in place by an expandable metal ring which was adjusted to open inside the Sulfonamide experiments rectum to hold the probe firmly in place. The victim was put into an air force From about July 1942 to about September uniform, then placed in the vat of cold 1943, experiments to investigate the water and started to freeze. effectiveness of sulfonamide, a synthetic antimicrobial agent, were conducted at http://www.myclinicalresearchbook.blogspot.com/
  • 3. Ravensbrück. Wounds inflicted on the of people with a minimum of time and subjects were infected with bacteria such effort. These experiments were conducted as Streptococcus, gas gangrene and by means of X-ray, surgery and various drugs. Thousands of victims were sterilized. Aside from its experimentation, the Nazi government sterilized around 400,000 individuals as part of its compulsory sterilization program. Intravenous injections of solutions speculated to contain iodine and silver tetanus. nitrate were successful, Circulation of blood was interrupted by tying off blood vessels at both ends of the wound to create a condition similar to that of a battlefield wound. Infection was aggravated by forcing wood shavings and ground glass into the wounds. The infection was treated with sulfonamide and other drugs to determine their effectiveness. but had unwanted side effects such as vaginal bleeding, Sea water experiments severe abdominal pain, and cervical cancer. Therefore, radiation treatment became the favored choice of sterilization. Specific amounts of exposure to radiation destroyed a person’s ability to produce ova or sperm. The radiation was administered through deception. Prisoners were brought From about into a room and asked to complete forms, July 1944 to about September 1944, which took two to three minutes. In this experiments were conducted at the Dachau time, the radiation treatment was concentration camp to study various administered and, unknown to the methods of making sea water drinkable. At prisoners, they were rendered completely one point, a group of roughly 90 Roma sterile. Many suffered severe radiation were deprived of food and given nothing burns. but sea water to drink by Dr. Hans Eppinger, leaving them gravely injured. Experiments with poison They were so dehydrated that others observed them licking freshly mopped In or around December 1943 and October floors in an attempt to get drinkable water. 1944, experiments were conducted at Buchenwald to investigate the effect of Sterilization experiments various poisons. The poisons were secretly administered to experimental subjects in From about March 1941 to about January their food. The victims died as a result of 1945, sterilization experiments were the poison or were killed immediately in conducted at Auschwitz, Ravensbrück, and order to permit autopsies. In September other places by Dr. Carl Clauberg. The 1944, experimental subjects were shot with purpose of these experiments was to poisonous bullets, suffered torture and develop a method of sterilization which often died. would be suitable for sterilizing millions http://www.myclinicalresearchbook.blogspot.com/
  • 4. Incendiary bomb experiments the trial, several of the doctors argued in their defense that there was no From around November 1943 through to international law regarding medical circa January 1944, experiments were experimentation. conducted at Buchenwald to test the effect of various pharmaceutical preparations on However, informed consent in German phosphorus burns. These burns were medicine was not original to issues inflicted on prisoners using phosphorus surrounding WWII. In 1900, Dr. Albert material extracted from incendiary bombs. Neisser infected patients (mainly prostitutes) with syphilis without their High altitude experiments consent. Despite support from most of the academic community, public opinion was against Neisser, led by psychiatrist Albert Moll. While Neisser went on to be fined by the Royal Disciplinary Court, Moll developed “a legally based, positivistic contract theory of the patient-doctor relationship” that was not adopted into German law. Eventually, the minister for religious, educational, and medical affairs issued a directive stating that medical interventions In early 1942, other than for diagnosis, healing, and prisoners at Dachau concentration camp immunization were excluded under all were used by Rascher in experiments to circumstances if “the human subject was a aid German pilots who had to eject at high minor or not competent for other reasons” altitudes. A low-pressure chamber or if the subject had not given his or her containing these prisoners was used to “unambiguous consent” after a “proper simulate conditions at altitudes of up to 20 explanation of the possible negative km (66,000 ft). It was rumored that consequences” of the intervention. Rascher performed vivisections on the However, this was not legally binding. brains of victims who survived the initial experiment.[20] Of the 200 subjects, 80 In response, Drs. Leo Alexander and died outright, and the others were Andrew Conway Ivy drafted a ten point executed. (See also Hubertus Strughold.) memorandum entitled Permissible Medical Experiment that went on to be known as Aftermath the Nuremberg Code. The code calls for such standards as voluntary consent of Many of the subjects died as a result of the patients, avoidance of unnecessary pain experiments conducted by the Nazis, while and suffering, and that there must be a many others were murdered after the tests belief that the experimentation will not end were completed or to study the effect post in death or disability. However, the Code mortem. Those who survived were often was not cited in any of the findings against left mutilated, suffering permanent the defendants and never made it into disability, weakened bodies, and mental either German or American medical law. duress. On August 19, 1947, the doctors captured by Allied forces were put on trial in USA vs. Karl Brandt et al., which is commonly known as the Doctors’ Trial. At http://www.myclinicalresearchbook.blogspot.com/
  • 5. Modern ethical issues The modern body of medical knowledge about how the human body reacts to freezing to the point of death is based almost exclusively on these Nazi experiments. This, together with the recent use of data from Nazi research into the effects of phosgene gas, has proved controversial and presents an ethical dilemma for modern physicians who do not agree with the methods used to obtain these data. Similarly, controversy has arisen from the use of results of biological warfare testing done by the Imperial Japanese Army’s Unit 731. However, the results from Unit 731 were kept classified by the United States and the majority of doctors involved were given pardons. i i Taken from:- www.wikipedia.org/wiki/Nazi_human_experiment ation http://www.myclinicalresearchbook.blogspot.com/