Market Research Report Search Engine Added "Synthetic Antispasmodics and Anticholinergics Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2016 - 2023" to its database.

1. Synthetic Antispasmodics and Anticholinergics Market
Competitive Dynamics & Global Outlook 2016 - 2023
Synthetic Antispasmodics and Anticholinergics Market
Synthetic drugs are produced in a laboratory employing
various chemical reactions. The chemical structure of these
synthetic drugs match naturally occurring drugs and they are

2. designed in such as way as to enhance their effects as
compared to naturally occurring drugs, or to prevent
undesired side effects. Many synthetic compounds without an
alternative natural source are classified by the chemical
structure of the parent synthetic compound. Pharmacological
activity within a group of common sore structure may vary
widely and produce different effects. The mechanism of
action of anticholinergic drugs involves blocking of
acetylcholine, nicotine, or muscarinic receptors. Distribution
of the muscarinic receptors is known to be in the central
nervous system (CNS), cardiac muscle, smooth muscle, and
the salivary glands. Nicotinic receptors are present in the
autonomic ganglia and on striated muscle. Antispasmodic
agents inhibit similar mechanism of action to anticholinergics.

3. They act by blocking the parasympathetic nerve impulses
leading to reduced smooth muscle spasms in the bladder and
the gastrointestinal tract.
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antispasmodics-anticholinergics-market
Synthetic Antispasmodics and Anticholinergics Market:
Segmentation
The anticholinergics and antispasmodics in clinical use
include natural, semi-synthetic and synthetic compounds that
demonstrate a multitude of actions on smooth muscle cells
and the parasympathetic nervous system. They are used to

4. treat spasms or conditions with disturbances in the bladder
or gastrointestinal motility. They are administered to treat
functional gastrointestinal disorders. The global synthetic
antispasmodic and anticholinergic drugs market has been
segmented based on the drug class.
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This includes synthetic anticholinergics, as esters with
tertiary amino group (oxyphencyclimine, camylofin,
mebeverine, trimebutine, rociverine, dicycloverine, others),
synthetic anticholinergics, as quaternary ammonium
compounds (benzilone, glycopyrronium, oxyphenonium,

5. penthienate, propantheline, carbachol, bevonium, poldine,
diphemanil, mepenzolate and others), synthetic antispasmodic,
as amides with tertiary amines
(dimethylaminopropionylphenothiazine, nicofetamide,
tiropramide), synthetic anticholinegic agents in combination
with psycholeptics (isopropamide with psycholeptics,
clidinium with psycholeptics and others), synthetic
antispasmodic agents in combination with analgesics
(tropenzilone with analgesics, bevonium with analgesics and
others), combination of antispasmodics, psycholeptics and
analgesics and synthetic antispasmodic agents with others
drugs.

6. Synthetic Antispasmodics and Anticholinergics Market: Drivers
and Restraints
The bulky ammonium side chain in the synthetic quaternary
ammonium derivatives makes these derivatives less likely to
cross membranes, such as the blood brain barrier, and thus
less likely to have central nervous system effects.
Commercial production of synthetic drugs is carried out by
drug manufacturers for valid medical purposes, however may
lead to diversion from legal channels across the globe
worldwide. Laboratory control knowledge, chemistry
background and an educated understanding of the process is
generally required for successful and safe synthesis of the
drugs.

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Antimuscarinic antispasmodic agents can be divided into
atropine and related belladonna alkaloids, and the synthetic
antimuscarinics (tertiary amine and quaternary ammonium
compounds). In gastroenterology these agents are used in the
relief of muscle spasm: anticholinergics have a dramatic
effect on smooth muscle spasm when administered IV, but
orally the effect is often disappointing; and for suppression of
gastric acid secretion, where the high doses needed are often
associated with considerable side-effects. More selective
gastric acid antisecretory agents are preferable and have

8. largely superseded agents formerly used. In the treatment of
irritable bowel syndrome, often a therapeutic dilemma, there
is some evidence that a high fibre maintenance diet combined
with short- term antispasmodics may be beneficial.
Some of the players contributing to the global synthetic
antispasmodics and anticholinergics market include Shire U.S,
Khandelwal Laboratories Pvt Ltd., Hospira, Inc., Dr. Reddys
Laboratories Ltd., Watson Laboratories, Inc., Ranbaxy, Inc.
and CorePharma, Inc.
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