Obesity therapeutics to 2019 safety concerns hinder drug performance despite large market opportunity - Reports Corner

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Obesity Therapeutics to 2019 - Safety Concerns Hinder
Drug Performance Despite Large Market Opportunity

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GBI Research, the leading business intelligence provider, has
released its latest research, “Obesity Therapeutics to 2019 -
Safety Concerns Hinder Drug Performance Despite Large Market
Opportunity”. Obesity is often described as a global endemic, with
incidence dramatically increasing over the past decades,
particularly in developed countries.

Brief SummaryBrief Summary
Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug
Performance Despite Large Market Opportunity
Summary
GBI Research, the leading business intelligence provider, has
released its latest research, “Obesity Therapeutics to 2019 -
Safety Concerns Hinder Drug Performance Despite Large Market
Opportunity”. Obesity is often described as a global endemic, with
incidence dramatically increasing over the past decades,
particularly in developed countries. Being overweight or obese is
a major risk factor in the development of many chronic diseases,
including cardiovascular diseases, cancer, and diabetes, of which
treatment incurs extensive economic and healthcare costs.
Numerous anti-obesity drugs have been approved in the past
decade, including Knoll Pharmaceutical’s Meridia (sibutramine)

and Acomplia (rimonabant), only for them to be removed from the
market due to evidence of suicidal thoughts, depression and
cardiovascular problems with their long-term use. As such,
healthcare professionals have a negative perception of such
drugs and do not widely prescribe them, a major barrier to the
growth of the anti-obesity therapeutics market.
Only orlistat is currently deemed safe for the long-term treatment
of obesity; being proven to produce a placebo-adjusted weight-
loss average of a limited 3kg. Two anti-obesity drugs were
approved in June and July 2012, and GBI Research believes that
only one, Vivus’ Qsymia, has a strong enough safety and efficacy
(average placebo-adjusted weight loss of 5kg at the medium dose)
profile to make a significant impact on the market, providing it is
proven safe in long-term-use studies. If proven safe, GBI
Research expects the sales of Qsymia and other drugs expected
to be

approved over the forecast period to increase the market size to
$2.7 billion. Although moderate, this is significantly below the
market potential given the size of the prevalence population.
Optimally safe and effective anti-obesity drugs which overcome
healthcare professionals’ negative opinions will have to be
developed if the size of the market is ever to reflect the prevalence
of obesity.
Scope
- The report analyzes the incidence of obesity, current treatment
options, pipeline and market forecasts, and deals surrounding
anti-obesity drugs.
- A brief introduction to obesity; detailed analysis of recent,
current and projected incidence trends; co-morbidities; economic
implications of their treatment; and the current treatment options

- Analysis of the currently marketed anti-obesity drugs, including
recent sales figures, safety and efficacy data, and a discussion of
each drug’s expected performance within the forecast period
- Comprehensive reviews of the pipeline for anti-obesity drugs,
including analysis by molecule type and mechanism of action
- Statistical analysis of clinical trial duration, size, and failure rate
by Phase and molecule type
- An in-depth forecast model for the anti-obesity drugs market in
the US, UK, France, Germany, Italy, Spain and Japan. Each model
is based on the anticipated market performance of marketed
drugs and those expected to be approved within the forecast
period, and takes into account drug cost, efficacy, safety, and
likely prescription volumes.
- A detailed discussion of the drivers and barriers for this
immature market.

Reasons to buy
The report will enhance your decision-making capability by
allowing you to -
- Understand the large number of potential molecular targets for
the development of an anti-obesity drug, as well as the strengths,
weaknesses, and risks of each drug type
- Gain an in-depth view of the current status of the anti-obesity
drug pipeline, including the most common molecular targets and
molecule types in development
- Observe the trends in clinical trial duration and size by Phase,
molecule type and mechanism of action, and use the clinical trial
failure rate analysis to assess the risk profiles of current and
future developmental programs
- Assess the potential clinical and commercial impact of current
late-stage pipeline molecules on the anti-obesity drugs market

- Analyze current and past deals surrounding anti-obesity drugs,
including their value, year of deal and in depth details of the
highest value deals.

Table of ContentsTable of Contents
1 Table of Contents
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 Etiology and Pathophysiology 9
2.2 Classification 9
2.3 Epidemiology 10
2.3.1 The US 10
2.3.2 Obesity in the Top Five European Markets 10
2.3.3 Japan 10
2.4 Comorbidities 11
2.4.1 Type 2 Diabetes 11
2.4.2 Hypertension 11
2.4.3 Dyslipidemia 11
2.4.4 Respiratory Problems 12
2.4.5 Osteoarthritis 12
2.4.6 Cancer Risk 12
2.5 Economic Burden 12
2.6 Current Therapy Options 12
2.6.1 Lifestyle and Behavioral Modifications 12
2.6.2 Bariatric Surgery 13
2.6.3 Pharmacotherapy 13
2.6.4 Treatment Algorithms and Prescription Habits 15
2.6.5 Method of Determining Treatment Effectiveness 16

2.7 Why Develop Therapeutic Anti-obesity Drugs? 16
3 Marketed Products 18
3.1 Amphetamine-like Drugs 18
3.1.1 Overview 18
3.1.2 Efficacy Profile 19
3.1.3 Safety Profile 19
3.2 Qsymia, Vivus, Inc. 19
3.2.1 Overview 19
3.2.4 Discussion 22
3.3 Orlistat 22
3.3.1 Overview 22
3.3.4 Discussion 25
3.4 Belviq, Arena Pharmaceuticals 26
3.4.1 Introduction 26
3.4.4 Discussion 27
3.5 Low Long-term Success Rate of Marketed Anti-Obesity Drugs 28
3.6 Discussion 29
4 Pipeline 33
4.1 Overview of Pipeline by Phase, Molecule Type and Molecular Target 33
4.2 Clinical Trial Duration and Size 36
4.2.1 Clinical Trial Duration 36

4.2.2 Clinical Trial Size 38
4.3 Clinical Trial Failure, Attrition Rate and Reasons for Clinical Trial Failure 39
4.4 Primary and Secondary Endpoints 41
4.5 Late-stage Drugs of the Developmental Pipeline 43
4.5.1 Contrave, Orexigen Therapeutics 43
4.5.2 Cametor, Norgine BV 45
4.5.3 Victoza, Novo Nordisk 47
4.5.4 Tesofensine (NeuroSearch) 50
4.6 Discussion 51
5 Market Forecasts 54
5.1 Global Market 54
5.2 The US 56
5.2.1 Epidemiology and Treatment Usage Patterns 56
5.2.2 Annual Cost of Therapy 56
5.2.3 Market Size 56
5.3 Europe 58
5.3.1 Treatment Usage Patterns 58
5.3.3 Market Size 61
5.4 Japan 63
5.4.1 Treatment Usage Patterns 63
5.4.3 Market Forecast 63
5.5 Discussion 64
5.6 Drivers and Barriers of the Anti-obesity Market 65
5.7 Obesity Market Drivers 65
5.7.1 Obesity is a Very Prevalent Disease with Large Potential Target Populations Globally 65

5.7.2 Recent Approval of Qsymia to Drive Market Growth Providing its Long-term Safety is Proved 65
5.7.3 Diversification of Molecular Targets 65
5.8 Obesity Market Barriers 66
5.8.1 Low Treatment Rate 66
5.8.2 Reimbursement Issues 66
6 Licensing and Co-Development Deals 67
6.1 Licensing Deals 67
6.1.1 EMD Serono Enters into Collaboration and Licensing Agreement with Theratechnologies 68
6.1.2 Amylin Pharma Enters into Licensing Agreement with Takeda Pharma 68
6.1.3 Palatin Technologies Extends License Agreement with AstraZeneca 69
6.1.4 Zealand Pharma Enters into Licensing and Collaboration Agreement with Boehringer Ingelheim 69
6.2 Co-development Deals 70
6.2.1 Isis Enters into Collaboration Agreement with Ortho-McNeil 71
6.2.2 Orexigen Therapeutics Enters into Co-development Agreement with Takeda Pharma for Contrave 71
7 Appendix 72
7.1 References 72
7.2 Abbreviations 76
7.3 All Pipeline Drugs by Phase 79
7.3.1 Discovery 79
7.3.2 Preclinical 80
7.3.3 Phase I 84
7.3.4 Phase II 85
7.3.5 Phase III 86
7.3.6 Pre-Registration 86
7.4 Market Forecasts to 2019 87
7.4.1 Global 87

7.4.2 The US 87
7.4.3 UK 88
7.4.4 France 88
7.4.5 Germany 88
7.4.6 Italy 89
7.4.7 Spain 89
7.4.8 Japan 89
7.5 Methodology 90
7.6 Secondary Research 90
7.7 Therapeutic Landscape 90
7.8 Epidemiology-Based Forecasting 91
7.9 Market Size by Geography 92
7.10 Pipeline Analysis 93
7.11 Contact Us 93
7.12 Disclaimer 93

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https://www.reportscorner.com/reports/27617/Obesity-Therapeutics-to-2019---Safety-
Concerns-Hinder-Drug-Performance-Despite-Large-Market-Opportunity/

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Obesity therapeutics to 2019 safety concerns hinder drug performance despite large market opportunity - Reports Corner

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Obesity therapeutics to 2019 safety concerns hinder drug performance despite large market opportunity - Reports Corner