2012

1. «Yissum Introduces a Novel
Method for Treating Cancer
Based on a Protein Encoded by
HIV-1»
«DNA repair gene involved in
tumours»
Sara Sofia Buelvas Londoño
Medical Student III Semester
Molecular Biology- Lina Martinez S.
August 12th 2012
UPB.

4. FOR CANCER
TREATMENT
new findings by
The Garvan Institute of Research and development
Medical research Company of the Hebrew
University of Jerusalem
consist
consist
Expression levels of
DNA repair gene ViF: a isolated protein
(MGMT) may play a from HIV-1 can be use
significant role in to increase the
tumour progression sensitivity of cancer
and indicates cells to radiotherapy
resistance to and chemotherapy
chemotherapy

5. DNA gene repair involved in
tumours
MGMT
(gene)
a biomarker of
response to
temozolomide, a
chemotherapeutic
agent.
may also play
a significant
role in tumour
progression

6. DNA gene repair involved in
tumours
MGMT
(gene)
In
expressed
different
in pituitary
levels
tumours.
HIG
LOW
H

7. DNA gene repair involved in
tumours
TUMOURS with low levels of
MGMT are more agressive but
also tend to respond to
chemotherapy because the gene
can’t no longer undo the damage
caused by the drug-

8. DNA gene repair involved in
tumours
Loss of MGMT expression may
contribute to the progressive
accumulation of genetic mutations
and cellular proliferation that
occurs.

9. DNA gene repair involved in
tumours
ONAL
PERS
OP INION
Knowing genes involved in cancer ,
finding a cure is easier and
kwowing the response that some
cancers have is veryhelpful to give
a determinated kind of treatment.

10. Yissum Introduces a Novel Method
for Treating Cancer Based on a
Protein Encoded by HIV-1
ViF
(HIV-1
protein)
inhibits DNA repair
specifically in activated
small peptide hematopoietic cells
derived from the following exposure to
HIV-1 Vif protein ionizing radiation.
rendering them
more susceptible
to radiotherapy
and
chemotherapy.

11. Yissum Introduces a Novel Method
for Treating Cancer Based on a
Protein Encoded by HIV-1
Vif-
derived
peptide prevents DNA
repair by inhibiting
a protein :
A3G
responsible for anti-
viral innate immunity
and also plays a role
in DNA repair in
lymphoid and myeloid
malignancies.

12. Yissum Introduces a Novel Method
for Treating Cancer Based on a
Protein Encoded by HIV-1
The novel Vif peptide has already been
shown to significantly increase the
efficiency of radiation therapy in cultured
lymphoma and myeloma cells beacause
the inhibition of the protein don’t let the
cells being repair.

13. Yissum Introduces a Novel Method
for Treating Cancer Based on a
Protein Encoded by HIV-1
An elevated DNA break-repair capacity in
several cancer cells often leads to radiation
resistance and severely limits the efficacy of
radiation treatment and chemotherapy, for
this reason is important the novel method of
repair inhibition.

14. Yissum Introduces a Novel Method
for Treating Cancer Based on a
Protein Encoded by HIV-1
ONAL
PERS
OP INION
This study is a new oportunity for
the management of cancer, it gives
another perspective for the
treatment and a very big advance in
the search of the cancer cure.

15. TI L I TY
CA LU
E DI
M Cancer is the second leading cause of
death in the world. Because of that the
knowledge of all the components is really
important for the management of the
desease.

16. TI L I TY
CA LU
E DI
M The first steps in every investigation
stimulates investigator to continue
researching and find results usefull
to the humanity, so this novel
methods can be improved for the
human benefit.

17. TI L I TY
CA LU
E DI
M
Discover genes that are expressed
in different kind of cancer helps to
know what treatment is more
effective or view if the cells have
an adecuate response to the
chemotherapy

18. TI L I TY
CA LU
E DI
M
The treatment with proteins
with no know essential
functions involving normal cell
physiology may have minimal
side effects, a very important
fact for the patients .

19. BIBLIOGRAPHY
DNA repair gene involved in tumours
(sciencealert, 30 JULY 2012 )
Yissum Introduces a Novel Method for Treating Cancer Based on a Protein
Encoded by HIV-1 (marketwatch, 9 JULY 2012)
MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB.
Fac. de Medicina, 2006. 208 p.