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AGENDA
✴Company Overview
✴Technology Differentiation
✴Product Solutions
✴Clinical Assessments
Company Overview
✴ Founded in 1999
✴ Over 5,000 systems installed
✴ Headquartered in Mountain View, CA
   – Sales & support: USA, Germany & Canada
   – Distributed in over 70 countries
✴ Financial
   – Revenue greater than 20% growth
   – Profitable Q4 2011
✴ 125 Employees
   – More than 12% of revenue invested in R&D
Management Team
  Tim Marcotte                P.J. Ryland
  COO                         VP Business Development and Corporate Accounts

  Recent Experience:          Recent Experience:
  VNUS Medical Technologies   Siemens, Acuson



Glen McLaughlin, Ph.D.        Scott Williams
Founder & CTO                 Sr. Director Global Service
Recent Experience:            Recent Experience:
Cardiac Pathways              Siemens, Acuson



Michael Gabler                Dan Tibbets
VP Engineering                Sr. Director Manufacturing
Recent Experience:            Recent Experience:
Aptix Corporation             Lamb Research, Boston Scientific



Doug Tefft
VP International
Recent Experience:
SonoSite, ATL
ACHIEVEMENTS                                                                                                    Pediatrics




2004           2005           2006              2007         2008            2009       2010             2011               2012




                  z.one advanced hardware




       z.one                                                                                             29 US patents issued
                                            z.one miniCart
                                                                z.one ultraCart     z.one ultraCart sp
ZONESonographyTM Technology(ZST) will become the next industry
standard method of generating ultrasound images as it is overcoming
a number of the barriers of digital beamformation.
ZST is two generations ahead
of traditional digital beamformation
technology.
— Frost & Sullivan 2011


 Technology:
  ✴ Fast image acquisition
  ✴ Continuous transmit /
    receive focus
  ✴ Channel and RF data
Digital Beamformation         Zone Sonography




Fast image acquisition provides Acoustic Currency
✴Improved temporal accuracy
✴Multiple modalities without compromise
Temporal image coherence




  No Motion Artifact   Motion Artifact
     due to fast        due to slow
    shutter speed      shutter speed
Compounding   Compounding + CD-Mode
Continuous Transmit / Receive focus
  Transmit provides better contrast resolution
 (-50 dB)                                        Zone Sonography       Beamformer
  Receive provides better detail resolution      Technology            Technology
 (-20 dB)
  No need to blend multiple Tx focus zone
 images
  Independent Nyquist sampling
requirements for Transmit and Receive
 Applicable for all multi dimensional
imaging modalities


                 ✴Image Benefits:
                 -Improved detail resolution
                 -Improved contrast resolution                     Legend
                 -Improved penetration
                 -Better uniformity                            PSF
                 -Improved Doppler sensitivity
Zone Sonogaphy         Beamformer
  Technology            Technology




                 PSF
Zone Sonography Technology   Beamformer Technology
CW
                                          CD           Scale     CD-Mode
                                          to
                                                                 Settings
Channel and RF data enables              Power

Patient Specific Imaging
✴ Sound speed correction                B-Mode          I/Q        PW-Mode
                                        Settings        Data        Settings
✴ Retrospective imaging capabilities                    Set

✴ Enhanced auto optimization capabilities
                                       Elastography               Auto
                                                                 Optimize
                                                      Contrast
                                                      Settings
Patient Specific Imaging

Variability of sound speed within
patients lead to lower detail and
contrast resolution resulting in
decreased diagnostic confidence

                                                                    V > 1540 m/s

sound speed correction reduces image
                                       V= 1540 m/s
variability across patients

                                                     V < 1540 m/s
Corrected SS (1540 m/s)
                    Assumed      (1480



 Patient Specific
Imaging (Phantom)
Patient Specific Imaging (Phantom)
      Corrected SS (1480 m/s)   Assumed SS (1540 m/s)
Corrected SS (1460 m/s)   Assumed SS (1540 m/s)
Clinical Solutions
✴ Radiology
   – Pediatrics
   – Bariatrics
✴ Vascular
✴ Interventional Radiology
✴ Emergency Department
Radiology: Pediatrics
✴ Premium imaging performance
   – Dynamic transmit / receive
     focus
   – Acoustic currency
   – Patient specific imaging
✴ Retrospective image
  processing
✴ Full transducer offering
   – C10-3, P10-4, C9-4t, & C9-3
✴ One touch image optimization
✴ Battery powered (3-hour)
✴ Wireless ready
✴ Highly mobile
Radiology: Bariatric
✴ Premium imaging performance
   – Dynamic transmit / receive focus
   – Acoustic currency
   – Patient specific imaging
✴ Full transducer offering
   – C4-1 & C6-2
✴ CW-Doppler on C4-1
   – Improved penetration / sensitivity
   – No aliasing
✴ One touch image optimization
✴ Battery powered (3-hours)
✴ Highly mobile
Vascular
✴ Premium image performance
   – Dynamic transmit / receive
     focus
   – Acoustic currency
   – Patient specific imaging
✴ Full transducer offering
   – L8-3, L10-5, L14-5sp, L14-5w,
     C9-3, C6-2 & P4-1c
✴ Intuitive user interface
✴ One touch image optimization
✴ Streamlined workflow
✴ Structured reporting
Interventional Radiology
✴ Premium image performance
   – Dynamic transmit / receive
     focus
   – Acoustic currency
   – Patient specific imaging
✴ Full transducer offering
   – L8-3, L10-5, L14-5sp, L14-
     5w, C9-3, C6-2 & P4-1c
✴ One touch image optimization
✴ Intuitive user interface
✴ Full screen display
  capabilities
✴ Battery powered (3-hours)
✴ Highly mobile
Emergency Department
✴ Premium image performance
   – Dynamic transmit / receive focus
   – Acoustic currency
   – Patient specific imaging
✴ Full transducer offering
   – L8-3, P4-1c, C4-1 & E9-4
✴ Intuitive user interface
✴ Full screen display capabilities
✴ One touch image optimization
✴ Battery powered (3-hours)
✴ Highly mobile
✴ Accreditation, reporting & billing packages
Clinical Assessment




Superior performance from
neonates to bariatrics
Clinical Assessment:     Cincinnati Children’s Hospital

   As an international leader in improving child
   health, Cincinnati Children’ s Hospital Medical
   Center is one of the largest pediatric radiology
   facilities in the country, performing more than
   200,000 imaging procedures each year. Clinical
   procedures and treatments pioneered at
   Cincinnati Children’s are used throughout the
   world. U.S. News & World Report has ranked
   Cincinnati Children’ s the third best children’s
   hospital in the nation in general pediatrics in its
   2011-12
14 day neonate coronal view
Competitive Premium System        ZONARE
Left kidney in 1 month neonate
Competitive Premium System        ZONARE
Right kidney transverse, abscess
Competitive Premium System       ZONARE
Patent IVC post liver transplant in 9 year old
  Competitive Premium System        ZONARE
Obese 16 year old liver / kidney
Competitive Premium System          ZONARE
Brian Coley         Radiologist-in-Chief, Cincinnati Children’ s Hospital Medical Center




“In my experience, the highly mobile ZONARE ultrasound
system delivers premium pediatric imaging performance
in practical applications. Using the C10-3, C9-3, and C6-2
transducers, ZONARE provides consistently uniform
imaging at depth on neonates to difficult to image
teenagers, with color Doppler performance comparable to
our other premium systems” said Dr. Coley.
Clinical Assessment:     Winnipeg’s Health Science Center

Winnipeg’s Health Science Centre is the largest
health care referral, teaching and research center
serving residents of Manitoba, Northwestern
Ontario and Nunavut and is one of the largest
facilities of its kind in Canada. The ultrasound
department conducts approximately 18,000
exams annually and is dedicated to providing
quality imaging using the most advanced
technology available.
Liver ascites
Morbidly Obese Patient
Morbidly Obese Patient
Edward Lyons          Professor and Past Chairman of Radiology, Professor of Obstetrics and Gynecology




“When imaging the liver in large patients with
ZONARE’s C6-2 and C4-1 probes, I feel that
the penetration and image quality is equivalent
to what I have seen on premium scanners
using similar probe technology,” said Dr. Lyons.
Zonare rsna powerpoint version 4 by 3
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Zonare rsna powerpoint version 4 by 3

  • 1.
  • 3. Company Overview ✴ Founded in 1999 ✴ Over 5,000 systems installed ✴ Headquartered in Mountain View, CA – Sales & support: USA, Germany & Canada – Distributed in over 70 countries ✴ Financial – Revenue greater than 20% growth – Profitable Q4 2011 ✴ 125 Employees – More than 12% of revenue invested in R&D
  • 4. Management Team Tim Marcotte P.J. Ryland COO VP Business Development and Corporate Accounts Recent Experience: Recent Experience: VNUS Medical Technologies Siemens, Acuson Glen McLaughlin, Ph.D. Scott Williams Founder & CTO Sr. Director Global Service Recent Experience: Recent Experience: Cardiac Pathways Siemens, Acuson Michael Gabler Dan Tibbets VP Engineering Sr. Director Manufacturing Recent Experience: Recent Experience: Aptix Corporation Lamb Research, Boston Scientific Doug Tefft VP International Recent Experience: SonoSite, ATL
  • 5. ACHIEVEMENTS Pediatrics 2004 2005 2006 2007 2008 2009 2010 2011 2012 z.one advanced hardware z.one 29 US patents issued z.one miniCart z.one ultraCart z.one ultraCart sp
  • 6. ZONESonographyTM Technology(ZST) will become the next industry standard method of generating ultrasound images as it is overcoming a number of the barriers of digital beamformation. ZST is two generations ahead of traditional digital beamformation technology. — Frost & Sullivan 2011 Technology: ✴ Fast image acquisition ✴ Continuous transmit / receive focus ✴ Channel and RF data
  • 7. Digital Beamformation Zone Sonography Fast image acquisition provides Acoustic Currency ✴Improved temporal accuracy ✴Multiple modalities without compromise
  • 8. Temporal image coherence No Motion Artifact Motion Artifact due to fast due to slow shutter speed shutter speed
  • 9. Compounding Compounding + CD-Mode
  • 10. Continuous Transmit / Receive focus Transmit provides better contrast resolution (-50 dB) Zone Sonography Beamformer Receive provides better detail resolution Technology Technology (-20 dB) No need to blend multiple Tx focus zone images Independent Nyquist sampling requirements for Transmit and Receive Applicable for all multi dimensional imaging modalities ✴Image Benefits: -Improved detail resolution -Improved contrast resolution Legend -Improved penetration -Better uniformity PSF -Improved Doppler sensitivity
  • 11. Zone Sonogaphy Beamformer Technology Technology PSF
  • 12. Zone Sonography Technology Beamformer Technology
  • 13. CW CD Scale CD-Mode to Settings Channel and RF data enables Power Patient Specific Imaging ✴ Sound speed correction B-Mode I/Q PW-Mode Settings Data Settings ✴ Retrospective imaging capabilities Set ✴ Enhanced auto optimization capabilities Elastography Auto Optimize Contrast Settings
  • 14. Patient Specific Imaging Variability of sound speed within patients lead to lower detail and contrast resolution resulting in decreased diagnostic confidence V > 1540 m/s sound speed correction reduces image V= 1540 m/s variability across patients V < 1540 m/s
  • 15. Corrected SS (1540 m/s) Assumed (1480 Patient Specific Imaging (Phantom)
  • 16. Patient Specific Imaging (Phantom) Corrected SS (1480 m/s) Assumed SS (1540 m/s)
  • 17. Corrected SS (1460 m/s) Assumed SS (1540 m/s)
  • 18. Clinical Solutions ✴ Radiology – Pediatrics – Bariatrics ✴ Vascular ✴ Interventional Radiology ✴ Emergency Department
  • 19. Radiology: Pediatrics ✴ Premium imaging performance – Dynamic transmit / receive focus – Acoustic currency – Patient specific imaging ✴ Retrospective image processing ✴ Full transducer offering – C10-3, P10-4, C9-4t, & C9-3 ✴ One touch image optimization ✴ Battery powered (3-hour) ✴ Wireless ready ✴ Highly mobile
  • 20. Radiology: Bariatric ✴ Premium imaging performance – Dynamic transmit / receive focus – Acoustic currency – Patient specific imaging ✴ Full transducer offering – C4-1 & C6-2 ✴ CW-Doppler on C4-1 – Improved penetration / sensitivity – No aliasing ✴ One touch image optimization ✴ Battery powered (3-hours) ✴ Highly mobile
  • 21. Vascular ✴ Premium image performance – Dynamic transmit / receive focus – Acoustic currency – Patient specific imaging ✴ Full transducer offering – L8-3, L10-5, L14-5sp, L14-5w, C9-3, C6-2 & P4-1c ✴ Intuitive user interface ✴ One touch image optimization ✴ Streamlined workflow ✴ Structured reporting
  • 22. Interventional Radiology ✴ Premium image performance – Dynamic transmit / receive focus – Acoustic currency – Patient specific imaging ✴ Full transducer offering – L8-3, L10-5, L14-5sp, L14- 5w, C9-3, C6-2 & P4-1c ✴ One touch image optimization ✴ Intuitive user interface ✴ Full screen display capabilities ✴ Battery powered (3-hours) ✴ Highly mobile
  • 23. Emergency Department ✴ Premium image performance – Dynamic transmit / receive focus – Acoustic currency – Patient specific imaging ✴ Full transducer offering – L8-3, P4-1c, C4-1 & E9-4 ✴ Intuitive user interface ✴ Full screen display capabilities ✴ One touch image optimization ✴ Battery powered (3-hours) ✴ Highly mobile ✴ Accreditation, reporting & billing packages
  • 24. Clinical Assessment Superior performance from neonates to bariatrics
  • 25. Clinical Assessment: Cincinnati Children’s Hospital As an international leader in improving child health, Cincinnati Children’ s Hospital Medical Center is one of the largest pediatric radiology facilities in the country, performing more than 200,000 imaging procedures each year. Clinical procedures and treatments pioneered at Cincinnati Children’s are used throughout the world. U.S. News & World Report has ranked Cincinnati Children’ s the third best children’s hospital in the nation in general pediatrics in its 2011-12
  • 26. 14 day neonate coronal view Competitive Premium System ZONARE
  • 27. Left kidney in 1 month neonate Competitive Premium System ZONARE
  • 28. Right kidney transverse, abscess Competitive Premium System ZONARE
  • 29. Patent IVC post liver transplant in 9 year old Competitive Premium System ZONARE
  • 30. Obese 16 year old liver / kidney Competitive Premium System ZONARE
  • 31. Brian Coley Radiologist-in-Chief, Cincinnati Children’ s Hospital Medical Center “In my experience, the highly mobile ZONARE ultrasound system delivers premium pediatric imaging performance in practical applications. Using the C10-3, C9-3, and C6-2 transducers, ZONARE provides consistently uniform imaging at depth on neonates to difficult to image teenagers, with color Doppler performance comparable to our other premium systems” said Dr. Coley.
  • 32. Clinical Assessment: Winnipeg’s Health Science Center Winnipeg’s Health Science Centre is the largest health care referral, teaching and research center serving residents of Manitoba, Northwestern Ontario and Nunavut and is one of the largest facilities of its kind in Canada. The ultrasound department conducts approximately 18,000 exams annually and is dedicated to providing quality imaging using the most advanced technology available.
  • 36. Edward Lyons Professor and Past Chairman of Radiology, Professor of Obstetrics and Gynecology “When imaging the liver in large patients with ZONARE’s C6-2 and C4-1 probes, I feel that the penetration and image quality is equivalent to what I have seen on premium scanners using similar probe technology,” said Dr. Lyons.