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Stratified Medicine –
Opportunities for Business




     24th January 2013
Session 2 – How Can Help Each 
Other?
 11:30 Space IDEAS Hub
  – Dr Andy Powell
 11:45 Intellectual Property
  – David Hopkins
 12:05 Funding through Business Angels/Venture 
 Capital
  – Jonathan Earl
 12:25 Questions
 12:35 Company Two‐Minute Pitches
Space IDEAS Hub




           Dr Andy Powell
Space IDEAS Hub, University of Leicester
Space IDEAS Hub: What is it?
 Helping business leverage our knowledge and expertise gained
 from 50 years of successfully delivering technology into space.

       Innovative: Solutions inspired by the challenges of
 I     working in space
       Design: Developing concepts into realistic solutions,
 D     meeting demanding requirements
       Engineering: Full project lifecycle delivery of
 E     mechanical, electrical, and software systems
       Analysis: Expertise in advanced tools for
 A     mathematical modelling and simulation; state-of-
       the-art test equipment to validate your product
       Support: Funding advice, proposal writing, free
  S    consultancy, business events, networking, training …
Space Pedigree




 Flight Programmes                   Operational Missions
 • Astrosat (Indian Space Research   •   Swift (NASA)
   Organisation)                     •   Chandra (NASA)
 • James Webb Space Telescope
   (NASA)
                                     •   XMM-Newton (ESA)
 • BepiColombo (ESA)                 •   Meteosat (EUMETSAT)
 • ExoMars(ESA/ROSCOSMOS)
Challenges We Overcome
 •   High sensitivity
 •   Extreme environment operations
 •   Light weight
 •   Compact
 •   High reliability / longevity
 •   Low power consumption
Technology Spin Out
 • Virtual Reconstruction of
   Reformation Tombs
 • Miniature Gamma-Ray
   Camera
 • Counterfeit Whiskey
   Detection
Case Studies
          Low Level Earth Observation      Medical Aid for Africa
          G2Way Ltd                        Inter Care
          • Payload options review         • Review of the reduction of
          • System operations analysis,       active elements in drugs
            flight plan assessment            using Raman Spectroscopy to
          • Low-cost conversion of COTS       allow unused drugs to be
            sensor to be ready for crop-      distributed in Africa
            health monitoring
          Distributed software             Natural Gas Fuel for Cars
          Meethub Ltd                      gasfill Ltd
          • Security analysis and design   • Investigation of options for
          • Web services specification        remote monitoring of
             and testing                      compressor operation to
          • Prototype deployment              ensure efficient operation
             methods and functional
             reviews
          Pressure Relief Beds             Drain Clearance
          Rober Ltd                        County Drains (Leicester) Ltd
          • Pneumatic design review of     • Strength testing of various
             current products                components
          • Optimisation of pneumatic      • Component characterisation
             control systems                 testing
Why Stratified Medicine?
 • Active in the Healthcare Sector
 • Showcase University of Leicester expertise
 • Bring businesses together to fuel innovation

 • Can we help with your business and
   technology challenges?
  – Initial consultancy FREE for East Midlands SMEs
Intellectual Property




         Dave Hoskins
 Intellectual Property Office
An Introduction to Intellectual Property
                     Dave Hopkins
             Business Outreach & Education
What is intellectual property?

                        Patents

    Plant                                     Trade
   Varieties                                  marks




                       Intellectual
                        Property
 Trade                                          Registered
Secrets                                          designs




          Confidentiality         Copyright
Trade Marks
A Registered Trade Mark is...

    Any sign which is capable
 of being represented graphically

    Any sign which is capable of
distinguishing the goods or services
  of one undertaking from another

      “A Badge of Origin”
What can be registered?

             Name    Logo
     Domain name     Slogan
      Colour theme   Shape theme
Non-traditional   Music       Smell
Trade Mark Registration Overseas

Paris Convention - six months priority

  OHIM – Community Trade Mark
        e-filing fee €900

          Madrid Protocol
Registered Designs
Registered Designs
Protects shape or configuration (3-D)
and/or pattern or ornamentation (2-D)

No protection for function, materials
  or technology of manufacture

 No protection when form is dictated
 by function (ie: no design freedom)
Registration Overseas

Paris Convention – 6 Months

OHIM - Community Design

    Hague Agreement
       (1/1/2008)
Patents
A motorised cycle 2008
Criteria for ‘patentability’
Patents are for “technological innovation”, though the
 Patents Act 1977 fails to define the word “invention”

       Inventions must be new - not known
    anywhere in the world prior to the filing date
    Inventions must have an ‘inventive step’ - not
     obvious, a simple adaptation or combination
      Inventions must be industrially applicable
             and have a ‘technical effect’
Copyright
What Copyright protects
Books, technical reports, manuals, databases

Engineering, technical or architectural plans
     Paintings, sculptures, photographs
     Music, songs, plays, dramatic works
      Promotional literature, advertising
 Films, videos, cable or radio broadcasts
             Computer software
Who owns Copyright?

     Usually the first creator or author...

  …or their employer if produced in the
  ordinary course of their employment

 However, a contractor will retain ownership
unless their contract is explicit to the contrary

Even if the creator sells their rights, they have
  ‘moral rights’ over how their work is used
www.ipo.gov.uk - 0300 300 2000
Thank you
Dave Hopkins

David.hopkins@ipo.gov.uk
Funding Through Business 
Angels and Venture Capital




         Jonathan Earl
   Catapult Venture Managers
Stratified Medicine – Opportunities for
                 Business
Funding Through Business Angels &
          Venture Capital
               Jonathan Earl
               Investment Director
        Catapult Venture Managers Limited
                   January 2013

              www.catapult-vm.co.uk
Agenda

•    Introduction to Catapult
•    A view of the UK funding market
•    Venture investing – what is it?
•    Venture Capital/Business Angels – when and why?
•    What can you expect from an equity investor?
•    What is an equity investor looking for?
•    What is the assessment process?
•    Investment examples
Introduction to Catapult

•   Venture capital investment house
•   Offices in the East and West Midlands
•   Invests throughout the UK
•   VC funding between £200K and £2M equity requirement
•   Manage three Venture Capital Funds
•   Total of £80m of funds under management
•    Active investor with over 100 investments made in 75
    companies
A view of the UK funding market

                                             •   Business Angels typically provide
                                                 £10k to £250k
                         Main Stock market   •   Equity gap £250k to £2-4m
                                             •   Equity gap funders include seed
                   LMBO/MBO funds                funds, Government leveraged
                                                 funds and Venture Capital Trusts
                       AIM
          Specialist                         •   Specialist funds - provide larger
           Funds
                                                 equity amounts in specific sectors,
          Equity                Debt             includes corporate venturing
           Gap
 Angels                                      •   AIM – for smaller listings; currently
                                                 difficult to access
                                             •   Leveraged MBO – large deals in
                                                 established profitable companies
Venture investing – what is it?

• Equity capital for earlier stage, high potential growth companies
• Ultimate goal is to generate a return via a realisation transaction (most
  commonly a trade sale, occasionally an IPO or secondary)
• Historically focussed on IP rich companies in specific sectors
• Today tends to have a broader remit
• VC/business angel investing is high risk, high potential reward
• Risk is diversified by holding a portfolio of investments
• Where does venture capital come from?
    - High net worth individuals (VCTs, EIS Funds)
    - Institutional investors
    - Public sector
    - Corporates
VC/Angels – when and why?

 • When: all stages of a business’ lifecycle
    - Start up / early stage
    - Development capital
    - Acquisitions
    - Transaction
 • Why: “if the bank won’t fund it, it’s an equity risk”
          “smaller slice of a larger pie”
VC/Angels – when and why?

Business Angels         Venture Capital         Debt
Quick decision          Partner to share risk   Relatively cheap
makers
                        Further funding         No equity requirement
Flexible re timing of
                        Flexible re timing of   Cash hungry
returns
                        returns
                                                Fixed commitments
Relatively expensive
                        Strengthens balance
                                                Risk averse - security
Advice and support      sheet
                                                Personal guarantees
Limited capacity        Comfort for banks /
                        suppliers               Lack of availability for
                                                early stage companies
                        Relatively expensive
                        NED support
What can you expect from an
equity investor?

 •   Requirement for an equity stake
 •   Introduction of a Non Executive Director/Chairman
 •   A comprehensive formal Investment Agreement
 •   An interested investor (level of involvement varies)
 •   Monitor and challenge performance
 •   Ability to provide further funding if required
 •   Regular review of exit routes
 •   Help and advice in delivering an exit
What is an equity investor
looking for?
•   Strong management team (may need augmenting)
•   Growth sectors favoured
•   Business capable of:
      i.   sustainable USP/competitive advantage
      ii. substantial growth
      iii. achieving an exit within 5 years
•   Scalable business model
•   Good business plan and financial forecasts
•   Honest assessment of risks
•   Return commensurate with risk
Management Team

• Clear leader (buck stops here!)
   - Decision maker
   - Ability to convey why the investor should invest
• Well rounded team – commercial, technology / R&D, sales & marketing,
  operations, finance
• NED to challenge, interface, understand investor requirements
• Proven pedigree
• Committed – time and £
In reality:
• Ideal team unlikely to exist in early stage investing
• VCs are used to multi-tasking teams and to helping to bridge gaps
What is a big turn off?

•   Lack of commitment from management team
•   Unrealistic timescale to market / milestone, leading to...
•   Unrealistic funding requirement
•   Lack of clarity on strategy / routes to market
•   Lack of clarity on investment requirement
    - How much, when and what for?
•   Dismissing risks
•   Long, expensive lead times to revenue / profit / exit
•   Turnover as a percentage of market size!
•   Poorly defined exit plan
What is the assessment process?

 •   Initial assessment via business plan
 •   Presentation / elevator pitch to investor
 •   Initial due diligence
 •   Terms negotiated                             Timescale
 •   Introduction of Non-executive Director        12 plus
                                                  weeks for
 •   Significant further due diligence
                                                     VCs
       -   Management, commercial and financial
 •   Investment Committee approval
 •   Legal process
Some investment examples


- Oncology biomarker business                 - Molecular diagnostics platform
- Investment to date of £1.7m                 - Enables low cost in-field testing
- Part of investor syndicate raising £7.5m    - Investment to date of £1m
- Investment to grow via partnering           - Investment to develop further applications
- Achieved several high profile deals         - 3M food testing deal and strong pipeline




- Molecular diagnostic kits                   - Clinical trial drug formulation and manufacture
- Genotype/antibodies re organ transplantation - Investment of £0.25m in December 2006
- Investment to date of £0.8m                 - Investment to complete facility and grow sales
- Investment to expand and commercialise      - Sold to Aesica Pharmaceuticals in June 2010
- Recent distribution agreement with pharma   - Significant money multiple return
Summary


• Equity funding often essential for ambitious growth co’s
• Research the funding market and identify best partners
• Build appropriate team
• Business plan summarising investment case
• Growth potential and exit plan clearly articulated
• Consider obtaining advice from fund raising/investment
  readiness specialists
• Long term relationship - mutually beneficial partnership
www.spaceideashub.com
     enquiries@spaceideashub.com
             0116 229 7700




        Contact us for a FREE 2‐day 
project, problem evaluation and consulting 
                 Space IDEAS Hub
                 @spaceideashub

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Stratified medicine - How Can We Help Each Other

  • 2. Session 2 – How Can Help Each  Other? 11:30 Space IDEAS Hub – Dr Andy Powell 11:45 Intellectual Property – David Hopkins 12:05 Funding through Business Angels/Venture  Capital – Jonathan Earl 12:25 Questions 12:35 Company Two‐Minute Pitches
  • 3. Space IDEAS Hub Dr Andy Powell Space IDEAS Hub, University of Leicester
  • 4. Space IDEAS Hub: What is it? Helping business leverage our knowledge and expertise gained from 50 years of successfully delivering technology into space. Innovative: Solutions inspired by the challenges of I working in space Design: Developing concepts into realistic solutions, D meeting demanding requirements Engineering: Full project lifecycle delivery of E mechanical, electrical, and software systems Analysis: Expertise in advanced tools for A mathematical modelling and simulation; state-of- the-art test equipment to validate your product Support: Funding advice, proposal writing, free S consultancy, business events, networking, training …
  • 5. Space Pedigree Flight Programmes Operational Missions • Astrosat (Indian Space Research • Swift (NASA) Organisation) • Chandra (NASA) • James Webb Space Telescope (NASA) • XMM-Newton (ESA) • BepiColombo (ESA) • Meteosat (EUMETSAT) • ExoMars(ESA/ROSCOSMOS)
  • 6. Challenges We Overcome • High sensitivity • Extreme environment operations • Light weight • Compact • High reliability / longevity • Low power consumption
  • 7. Technology Spin Out • Virtual Reconstruction of Reformation Tombs • Miniature Gamma-Ray Camera • Counterfeit Whiskey Detection
  • 8. Case Studies Low Level Earth Observation Medical Aid for Africa G2Way Ltd Inter Care • Payload options review • Review of the reduction of • System operations analysis, active elements in drugs flight plan assessment using Raman Spectroscopy to • Low-cost conversion of COTS allow unused drugs to be sensor to be ready for crop- distributed in Africa health monitoring Distributed software Natural Gas Fuel for Cars Meethub Ltd gasfill Ltd • Security analysis and design • Investigation of options for • Web services specification remote monitoring of and testing compressor operation to • Prototype deployment ensure efficient operation methods and functional reviews Pressure Relief Beds Drain Clearance Rober Ltd County Drains (Leicester) Ltd • Pneumatic design review of • Strength testing of various current products components • Optimisation of pneumatic • Component characterisation control systems testing
  • 9. Why Stratified Medicine? • Active in the Healthcare Sector • Showcase University of Leicester expertise • Bring businesses together to fuel innovation • Can we help with your business and technology challenges? – Initial consultancy FREE for East Midlands SMEs
  • 10. Intellectual Property Dave Hoskins Intellectual Property Office
  • 11. An Introduction to Intellectual Property Dave Hopkins Business Outreach & Education
  • 12. What is intellectual property? Patents Plant Trade Varieties marks Intellectual Property Trade Registered Secrets designs Confidentiality Copyright
  • 14.
  • 15. A Registered Trade Mark is... Any sign which is capable of being represented graphically Any sign which is capable of distinguishing the goods or services of one undertaking from another “A Badge of Origin”
  • 16. What can be registered? Name Logo Domain name Slogan Colour theme Shape theme Non-traditional Music Smell
  • 17. Trade Mark Registration Overseas Paris Convention - six months priority OHIM – Community Trade Mark e-filing fee €900 Madrid Protocol
  • 19.
  • 20. Registered Designs Protects shape or configuration (3-D) and/or pattern or ornamentation (2-D) No protection for function, materials or technology of manufacture No protection when form is dictated by function (ie: no design freedom)
  • 21. Registration Overseas Paris Convention – 6 Months OHIM - Community Design Hague Agreement (1/1/2008)
  • 24. Criteria for ‘patentability’ Patents are for “technological innovation”, though the Patents Act 1977 fails to define the word “invention” Inventions must be new - not known anywhere in the world prior to the filing date Inventions must have an ‘inventive step’ - not obvious, a simple adaptation or combination Inventions must be industrially applicable and have a ‘technical effect’
  • 26. What Copyright protects Books, technical reports, manuals, databases Engineering, technical or architectural plans Paintings, sculptures, photographs Music, songs, plays, dramatic works Promotional literature, advertising Films, videos, cable or radio broadcasts Computer software
  • 27. Who owns Copyright? Usually the first creator or author... …or their employer if produced in the ordinary course of their employment However, a contractor will retain ownership unless their contract is explicit to the contrary Even if the creator sells their rights, they have ‘moral rights’ over how their work is used
  • 30. Funding Through Business  Angels and Venture Capital Jonathan Earl Catapult Venture Managers
  • 31. Stratified Medicine – Opportunities for Business Funding Through Business Angels & Venture Capital Jonathan Earl Investment Director Catapult Venture Managers Limited January 2013 www.catapult-vm.co.uk
  • 32. Agenda • Introduction to Catapult • A view of the UK funding market • Venture investing – what is it? • Venture Capital/Business Angels – when and why? • What can you expect from an equity investor? • What is an equity investor looking for? • What is the assessment process? • Investment examples
  • 33. Introduction to Catapult • Venture capital investment house • Offices in the East and West Midlands • Invests throughout the UK • VC funding between £200K and £2M equity requirement • Manage three Venture Capital Funds • Total of £80m of funds under management • Active investor with over 100 investments made in 75 companies
  • 34. A view of the UK funding market • Business Angels typically provide £10k to £250k Main Stock market • Equity gap £250k to £2-4m • Equity gap funders include seed LMBO/MBO funds funds, Government leveraged funds and Venture Capital Trusts AIM Specialist • Specialist funds - provide larger Funds equity amounts in specific sectors, Equity Debt includes corporate venturing Gap Angels • AIM – for smaller listings; currently difficult to access • Leveraged MBO – large deals in established profitable companies
  • 35. Venture investing – what is it? • Equity capital for earlier stage, high potential growth companies • Ultimate goal is to generate a return via a realisation transaction (most commonly a trade sale, occasionally an IPO or secondary) • Historically focussed on IP rich companies in specific sectors • Today tends to have a broader remit • VC/business angel investing is high risk, high potential reward • Risk is diversified by holding a portfolio of investments • Where does venture capital come from? - High net worth individuals (VCTs, EIS Funds) - Institutional investors - Public sector - Corporates
  • 36. VC/Angels – when and why? • When: all stages of a business’ lifecycle - Start up / early stage - Development capital - Acquisitions - Transaction • Why: “if the bank won’t fund it, it’s an equity risk” “smaller slice of a larger pie”
  • 37. VC/Angels – when and why? Business Angels Venture Capital Debt Quick decision Partner to share risk Relatively cheap makers Further funding No equity requirement Flexible re timing of Flexible re timing of Cash hungry returns returns Fixed commitments Relatively expensive Strengthens balance Risk averse - security Advice and support sheet Personal guarantees Limited capacity Comfort for banks / suppliers Lack of availability for early stage companies Relatively expensive NED support
  • 38. What can you expect from an equity investor? • Requirement for an equity stake • Introduction of a Non Executive Director/Chairman • A comprehensive formal Investment Agreement • An interested investor (level of involvement varies) • Monitor and challenge performance • Ability to provide further funding if required • Regular review of exit routes • Help and advice in delivering an exit
  • 39. What is an equity investor looking for? • Strong management team (may need augmenting) • Growth sectors favoured • Business capable of: i. sustainable USP/competitive advantage ii. substantial growth iii. achieving an exit within 5 years • Scalable business model • Good business plan and financial forecasts • Honest assessment of risks • Return commensurate with risk
  • 40. Management Team • Clear leader (buck stops here!) - Decision maker - Ability to convey why the investor should invest • Well rounded team – commercial, technology / R&D, sales & marketing, operations, finance • NED to challenge, interface, understand investor requirements • Proven pedigree • Committed – time and £ In reality: • Ideal team unlikely to exist in early stage investing • VCs are used to multi-tasking teams and to helping to bridge gaps
  • 41. What is a big turn off? • Lack of commitment from management team • Unrealistic timescale to market / milestone, leading to... • Unrealistic funding requirement • Lack of clarity on strategy / routes to market • Lack of clarity on investment requirement - How much, when and what for? • Dismissing risks • Long, expensive lead times to revenue / profit / exit • Turnover as a percentage of market size! • Poorly defined exit plan
  • 42. What is the assessment process? • Initial assessment via business plan • Presentation / elevator pitch to investor • Initial due diligence • Terms negotiated Timescale • Introduction of Non-executive Director 12 plus weeks for • Significant further due diligence VCs - Management, commercial and financial • Investment Committee approval • Legal process
  • 43. Some investment examples - Oncology biomarker business - Molecular diagnostics platform - Investment to date of £1.7m - Enables low cost in-field testing - Part of investor syndicate raising £7.5m - Investment to date of £1m - Investment to grow via partnering - Investment to develop further applications - Achieved several high profile deals - 3M food testing deal and strong pipeline - Molecular diagnostic kits - Clinical trial drug formulation and manufacture - Genotype/antibodies re organ transplantation - Investment of £0.25m in December 2006 - Investment to date of £0.8m - Investment to complete facility and grow sales - Investment to expand and commercialise - Sold to Aesica Pharmaceuticals in June 2010 - Recent distribution agreement with pharma - Significant money multiple return
  • 44. Summary • Equity funding often essential for ambitious growth co’s • Research the funding market and identify best partners • Build appropriate team • Business plan summarising investment case • Growth potential and exit plan clearly articulated • Consider obtaining advice from fund raising/investment readiness specialists • Long term relationship - mutually beneficial partnership
  • 45. www.spaceideashub.com enquiries@spaceideashub.com 0116 229 7700 Contact us for a FREE 2‐day  project, problem evaluation and consulting  Space IDEAS Hub @spaceideashub