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Oncology Global Strategic Marketing:
             Benchmarking Budget Levels & Service Scope




                                          Best Practices, LLC
                                   Strategic Benchmarking Research



Copyright © Best Practices®, LLC                  1                  BEST PRACTICES,®
                                                                                        LLC
Research Objective & Study Methodology
Best Practices, LLC conducted this benchmarking study to establish meaningful benchmarks for
the resource levels and the services scope of Global Strategic Marketing (GSM) organizations
supporting Oncology products and programs.

                      Study Overview                                 Topics Included
  Research Objective: Oncology-Global Strategic             Total investment for Oncology-GSM
  Marketing (GSM) organizations today face increasing
                                                            Distribution of budget across 6 key
  regulatory, regional and competitive challenges           functional areas and across product
  in a crowded market.                                      development phases
  This study seeks to help Oncology-GSM leaders             Commercial spend - % budget allocated
  understand the investment levels, marketing activities,   at launch & post-launch phases
  timing and structures needed to successfully steer        Total # FTEs supporting GSM functions
  products and pipeline programs through the complex
  Oncology marketplace.                                     Distribution of FTEs across 8 major
                                                            activity areas
  Research findings provide industry metrics that
  will serve as a reference point for GSM leaders in        % FTEs dedicated to developing and
                                                            “rest of world” markets
  budgeting and strategic planning.
                                                            Use of outsourcing and off-shoring
   Methodology: Best Practices, LLC developed               # products, labels & programs
  a customized survey tool to capture industry data         supported
  and deployed it to a representative sample of 17          Key Ratios: GSM investment/Oncology
  pharmaceutical companies with Oncology                    Sales, FTEs/$100M revenue, GSM $/
  programs and portfolios.                                  product, & GSM $/pipeline program

Copyright © Best Practices®, LLC                       2               BEST PRACTICES,   ®
                                                                                             LLC
Participating Companies & Data Segmentation
Benchmark participants included GSM leaders supporting Oncology organizations at 17 companies.
The study included both large, established and small, emerging Oncology companies to provide
broadest insights. Data is presented for large and emerging company segments throughout the report.

                                    Participating Companies
                                                                           Large Companies:
                                                                     •   Abbott
                                                                     •   Astellas
                                                                     •   AstraZeneca
                                                                     •   Baxter Oncology GmbH
                                                                     •   Bayer
                                                                     •   Boehringer Ingelheim
                                                                     •   Bristol-Myers Squibb
                                                                     •   Eisai Inc
                                                                     •   Merck Serono
                                                                     •   Onyx Pharmaceuticals
                                                                     •   Sanofi
                                                                     •   Takeda
                                                                          Emerging Companies:
                                                                     •Exelixis
                                                                     •Gilead Sciences, Inc.
                                                                     •MedImmune
                                                                     •Monogram Biosciences
                                                                     •Selvita S.A.

 Copyright © Best Practices®, LLC               3                    BEST PRACTICES,   ®
                                                                                           LLC
Key Findings 2: Normalized Metrics & Ratios
The following key findings, observations, insights and metrics emerged from this
benchmarking study.


   GSM Spend per Pipeline Program Averages > $800K at Big Companies: Large company GSM
   spend per Oncology program in the pre-launch phases ranges from under $100K to $2 million, with
   an average of $805,231. The average for emerging companies is $201,894.
   Large Company GSM Supports Average of 16.4 Oncology Pipeline Programs: GSM organizations
   in the large company segment support an average of 16.4 pipeline programs, while emerging companies
   support an average of 9.4.
   GSM Spend per In-Market Oncology Product Averages $6.2M: GSM spend per in-market Oncology
   product ranges from $200,000 to more than $16 million, with an average of $6.2 million.
   Average per-Label GSM Spend Tops $2.8M: GSM spend per Oncology label ranges from $66,667
   to $8.3 million across the benchmark class. On average, the GSM investment per label is $2.8 million.
   GSM Supports Average of <2 Oncology Products & <4 Labels: Large company GSM organizations
   support an average of 1.75 in-market Oncology products and 3.75 labels. Emerging company GSM
   predominantly supports development programs rather than products, and the averages reflect that
   position, with 0.8 products and one label supported.
   Total Oncology-GSM Spend Averages Nearly 1% of Sales: GSM investment as a percentage of total
   Oncology sales averages just under 1% for the largest companies (over $1 billion Oncology revenue) in
   the benchmark class. Their GSM investment ranges from 0.1% to 2.5% of sales.
   Commercial Investment as Percentage of Sales Averages 0.84%: GSM investment for commercial
   phases averages 0.84% of total Oncology product sales for the large company segment. The ratio ranges
   from 0.03% to 2%.

Copyright © Best Practices®, LLC                    4                      BEST PRACTICES,    ®
                                                                                                  LLC
Key Findings 5: GSM Leadership & Future Investment Trends
The following key findings, observations, insights and metrics emerged from this
benchmarking study.



                                       ONCOLOGY-GSM LEADERSHP

      GSM Often Has Full Lifecycle Involvement: A majority of Oncology-GSM groups maintain a
      leadership role in the Launch and Post-Launch phases of product development.

      GSM Key Leadership Areas Are Market Intelligence & Marketing: In the early phases of product
      development, Oncology-GSM most often takes a lead role in Market Intelligence activities. After
      Phase II, Marketing is the area where GSM most frequently leads.

                                               INVESTMENT TRENDS

      Up to 73% Expect Increased GSM Funds for Pipeline Marketing: Budget increases are
      anticipated by as many as 73% of benchmark participants for activities supporting the Oncology
      pipeline. Activities most often expected to gain are ad boards, marketing and market intelligence.
      Few project any decreases.

      Up to 42% Expect GSM Increases for In-Line Product Marketing: More benchmark participants
      anticipate GSM investment level decreases and fewer anticipate increases for in-line products than
      for pipeline products. Marketing is projected to as the top area for funding increases, and the top
      area for cuts is Congresses. Interestingly, companies are evenly split at 33% on whether funding for
      Ad Boards will go up, down or remain unchanged.

Copyright © Best Practices®, LLC                      5                      BEST PRACTICES,     ®
                                                                                                     LLC
Marketing Activities Take Biggest Share of Total GSM Spend
 At large companies, the top two activity areas—Marketing and Market Intelligence—account
 for 51% of the total Oncology-GSM budget. Emerging companies focus even more on those
 two key areas, with a combined 68% of total funds channeled there.


                   Percentage of GSM Investment Allocated to Key Activity Areas

                    Large Companies                                       Emerging Companies


           Advocacy                                    OTHER:
                           Other Thought              Websites,                      Thought
                         5% 4% Leaders                 Training,                      Leaders/
                                                       Strategic                      KOLs
                                   /KOLs
                                                       Council           Market
                                    11% Global         Training,                     10% Congresses/
                  Market                Congresses
                                                                      Intelligence
                                                       E-media                             Conventions
              Intelligence             /Convention   Personalized         31%
                                                                                         13%
                    20%               Management      Healthcare
                                          20%                                              Ad Boards
                                                                                               11%
                                        Advisory
                                         Boards                              Marketing
                    Marketing
                                          9%                                   37%
                       31%

         N=12                                                       N=5

       Q. What percentage of the total Oncology-GSM investment was allocated to each activity
                                category during the last fiscal year?

Copyright © Best Practices®, LLC                        6                     BEST PRACTICES,    ®
                                                                                                     LLC
Product Strategy Has Biggest Share of GSM Marketing Spend
Spending patterns are similar for the large and emerging company segments, with product
strategy consuming more than 70% of total GSM budgets and speaker training taking the smallest
share at only 4%.

     Q. Estimate the percentage of the Marketing Activities budget category that was allocated to
               each of the following activity sub-categories during the last fiscal year.

                         Marketing Activities: Investment Allocation Breakout

                       Large Companies                                        Emerging Companies

   Websites                  Other                                                                  Speaker
Market Access/
                               3% PR,   Speaker                                             PR,     Training
Reimbursement
                                        Training                                           Media      1%
                                 Media
                                  9% 5%                                                     9%
                                                                                              Publications
                  Product            Pubs                                                        21%
                  Strategy           12%                                        Product
                                                 Product Strategy
                    70%
                                                includes branding,
                                                                                Strategy
                                               product campaigning                72%
                                                & strategic marketing
                                                     planning.

           N=11                                                         N=4


 Copyright © Best Practices®, LLC                    7                          BEST PRACTICES,    ®
                                                                                                       LLC
Market Intel Activities Most Often Involve GSM Leadership
Market Intelligence is the area where GSM organizations most frequently take on a lead role, with a
large majority leading at all product development phases. At Phase II, 85% of participating GSM
organizations take the lead for Marketing Intelligence activities.



                     Role in Market Intelligence Activities by Development Phase

                                   Lead          Support              None

                                           77%                        15%       8%          Market
       Pre-Clinical
                                                                                         Intelligence
                                                                                          Activities
             Phase I                       77%                      8%      15%
                                                                                      Activities
                                                                                      included in
            Phase II                        85%                           8% 8%       survey definition:
                                                                                      Pricing, Health
           Phase III                       79%                           14%     7%
                                                                                      Economics,
                                                                                      Market Access,
            Launch                        71%                       21%          7%   Market Research,
                                                                                      Forecasting, &
     Post-Launch                          71%                      14%         14%    Business/
                                                                                      Competitive
                                                                                      Intelligence
   N=14                                              % Responses


       Q. For Market Intelligence activities, please indicate the type of role that Oncology Global
                       Strategic Marketing plays in at each development phase.

Copyright © Best Practices®, LLC                     8                    BEST PRACTICES,     ®
                                                                                                  LLC
Additional Activities Led or Supported by Oncology-GSM
Benchmarked GSM-Organizations lead or support a variety of additional activities not included in
the survey. These range from developing e-media to developing payer information around
personalized healthcare.

                               Additional GSM Activity Involvement by Phase
                                        Pre-                                                           Post-
                                                  Phase I:   Phase II:   Phase III:   Launch:
                                      Clinical:                                                       Launch
  Personalized Healthcare /
                                                     x
            Payer evidence

                      Forecasting                    x          x            x           x

           M&S cost planning                         x          x            x           x

                           Training                                                      x                x

       Educational programs                                                                               x

                           E-media                                                                        x


     Q. In the past fiscal year, what other important activities (not listed in survey) were led or
       supported by Oncology GSM? (List additional GSM activities conducted at each phase.)

Copyright © Best Practices®, LLC                         9                  BEST PRACTICES,     ®
                                                                                                    LLC
Voices from the Field: Key Success Factors in Oncology-GSM
                       Verbatim Responses from Benchmark Partners

                           “Close co-operation between global, regions and countries – ‘common language’ &
   Global Issues             common targets.”
                           “Ensure development of global brand and quick execution globally.”
                           “Proper leadership in building the oncology organization (including other functional
                             areas, such as Medical Affairs).”
    Collaboration
                           “Develop a strong global Medical Affairs organization.”
                           “Seek appropriate Commercial input on clinical development plans.”
                           “Gain KOL support earlier than launch phase-- especially if new technology is involved.”
        New
    Technology,            “Understanding the impact of biomarkers and diagnostic capabilities.”
      Markets,             “Personalized medicine, cost of therapy.”
    Stakeholders
                           “Define the right target audience, including new stakeholders (e.g., on biomarkers).”
                           “Patient segmentation, efficacy and safety requirements, personalized care, payer &
        Market               market access requirements.”
        Access
                           “Market access is becoming more and more critical.”

        Other              “Segment the market so positioning is performed for all market segments.”
       Success             “Accelerate uptake through EAP at launch.”
       Factors             “Strategic planning is vital.”
    Q. What issues will be critical for Oncology Global Strategic Marketing to address in the next
    24-36 months to ensure the success of products your organization hopes to bring to market?
 Copyright © Best Practices®, LLC                            10                        BEST PRACTICES,      ®
                                                                                                                LLC
About Best Practices, LLC

              Best Practices, LLC is a research and consulting firm that conducts
              work based on the simple yet profound principle that organizations
              can chart a course to superior economic performance by studying
              the best business practices, operating tactics and winning
                              strategies of world-class companies.




                                     Best Practices, LLC
                        6350 Quadrangle Drive, Suite 200, Chapel Hill, NC 27517
                                            919-403-0251
                                  bestpractices@best-in-class.com
                                       www.best-in-class.com




Copyright © Best Practices®, LLC                  11                 BEST PRACTICES,®
                                                                                        LLC

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Oncology Global Strategic Marketing

  • 1. Oncology Global Strategic Marketing: Benchmarking Budget Levels & Service Scope Best Practices, LLC Strategic Benchmarking Research Copyright © Best Practices®, LLC 1 BEST PRACTICES,® LLC
  • 2. Research Objective & Study Methodology Best Practices, LLC conducted this benchmarking study to establish meaningful benchmarks for the resource levels and the services scope of Global Strategic Marketing (GSM) organizations supporting Oncology products and programs. Study Overview Topics Included Research Objective: Oncology-Global Strategic Total investment for Oncology-GSM Marketing (GSM) organizations today face increasing Distribution of budget across 6 key regulatory, regional and competitive challenges functional areas and across product in a crowded market. development phases This study seeks to help Oncology-GSM leaders Commercial spend - % budget allocated understand the investment levels, marketing activities, at launch & post-launch phases timing and structures needed to successfully steer Total # FTEs supporting GSM functions products and pipeline programs through the complex Oncology marketplace. Distribution of FTEs across 8 major activity areas Research findings provide industry metrics that will serve as a reference point for GSM leaders in % FTEs dedicated to developing and “rest of world” markets budgeting and strategic planning. Use of outsourcing and off-shoring Methodology: Best Practices, LLC developed # products, labels & programs a customized survey tool to capture industry data supported and deployed it to a representative sample of 17 Key Ratios: GSM investment/Oncology pharmaceutical companies with Oncology Sales, FTEs/$100M revenue, GSM $/ programs and portfolios. product, & GSM $/pipeline program Copyright © Best Practices®, LLC 2 BEST PRACTICES, ® LLC
  • 3. Participating Companies & Data Segmentation Benchmark participants included GSM leaders supporting Oncology organizations at 17 companies. The study included both large, established and small, emerging Oncology companies to provide broadest insights. Data is presented for large and emerging company segments throughout the report. Participating Companies Large Companies: • Abbott • Astellas • AstraZeneca • Baxter Oncology GmbH • Bayer • Boehringer Ingelheim • Bristol-Myers Squibb • Eisai Inc • Merck Serono • Onyx Pharmaceuticals • Sanofi • Takeda Emerging Companies: •Exelixis •Gilead Sciences, Inc. •MedImmune •Monogram Biosciences •Selvita S.A. Copyright © Best Practices®, LLC 3 BEST PRACTICES, ® LLC
  • 4. Key Findings 2: Normalized Metrics & Ratios The following key findings, observations, insights and metrics emerged from this benchmarking study. GSM Spend per Pipeline Program Averages > $800K at Big Companies: Large company GSM spend per Oncology program in the pre-launch phases ranges from under $100K to $2 million, with an average of $805,231. The average for emerging companies is $201,894. Large Company GSM Supports Average of 16.4 Oncology Pipeline Programs: GSM organizations in the large company segment support an average of 16.4 pipeline programs, while emerging companies support an average of 9.4. GSM Spend per In-Market Oncology Product Averages $6.2M: GSM spend per in-market Oncology product ranges from $200,000 to more than $16 million, with an average of $6.2 million. Average per-Label GSM Spend Tops $2.8M: GSM spend per Oncology label ranges from $66,667 to $8.3 million across the benchmark class. On average, the GSM investment per label is $2.8 million. GSM Supports Average of <2 Oncology Products & <4 Labels: Large company GSM organizations support an average of 1.75 in-market Oncology products and 3.75 labels. Emerging company GSM predominantly supports development programs rather than products, and the averages reflect that position, with 0.8 products and one label supported. Total Oncology-GSM Spend Averages Nearly 1% of Sales: GSM investment as a percentage of total Oncology sales averages just under 1% for the largest companies (over $1 billion Oncology revenue) in the benchmark class. Their GSM investment ranges from 0.1% to 2.5% of sales. Commercial Investment as Percentage of Sales Averages 0.84%: GSM investment for commercial phases averages 0.84% of total Oncology product sales for the large company segment. The ratio ranges from 0.03% to 2%. Copyright © Best Practices®, LLC 4 BEST PRACTICES, ® LLC
  • 5. Key Findings 5: GSM Leadership & Future Investment Trends The following key findings, observations, insights and metrics emerged from this benchmarking study. ONCOLOGY-GSM LEADERSHP GSM Often Has Full Lifecycle Involvement: A majority of Oncology-GSM groups maintain a leadership role in the Launch and Post-Launch phases of product development. GSM Key Leadership Areas Are Market Intelligence & Marketing: In the early phases of product development, Oncology-GSM most often takes a lead role in Market Intelligence activities. After Phase II, Marketing is the area where GSM most frequently leads. INVESTMENT TRENDS Up to 73% Expect Increased GSM Funds for Pipeline Marketing: Budget increases are anticipated by as many as 73% of benchmark participants for activities supporting the Oncology pipeline. Activities most often expected to gain are ad boards, marketing and market intelligence. Few project any decreases. Up to 42% Expect GSM Increases for In-Line Product Marketing: More benchmark participants anticipate GSM investment level decreases and fewer anticipate increases for in-line products than for pipeline products. Marketing is projected to as the top area for funding increases, and the top area for cuts is Congresses. Interestingly, companies are evenly split at 33% on whether funding for Ad Boards will go up, down or remain unchanged. Copyright © Best Practices®, LLC 5 BEST PRACTICES, ® LLC
  • 6. Marketing Activities Take Biggest Share of Total GSM Spend At large companies, the top two activity areas—Marketing and Market Intelligence—account for 51% of the total Oncology-GSM budget. Emerging companies focus even more on those two key areas, with a combined 68% of total funds channeled there. Percentage of GSM Investment Allocated to Key Activity Areas Large Companies Emerging Companies Advocacy OTHER: Other Thought Websites, Thought 5% 4% Leaders Training, Leaders/ Strategic KOLs /KOLs Council Market 11% Global Training, 10% Congresses/ Market Congresses Intelligence E-media Conventions Intelligence /Convention Personalized 31% 13% 20% Management Healthcare 20% Ad Boards 11% Advisory Boards Marketing Marketing 9% 37% 31% N=12 N=5 Q. What percentage of the total Oncology-GSM investment was allocated to each activity category during the last fiscal year? Copyright © Best Practices®, LLC 6 BEST PRACTICES, ® LLC
  • 7. Product Strategy Has Biggest Share of GSM Marketing Spend Spending patterns are similar for the large and emerging company segments, with product strategy consuming more than 70% of total GSM budgets and speaker training taking the smallest share at only 4%. Q. Estimate the percentage of the Marketing Activities budget category that was allocated to each of the following activity sub-categories during the last fiscal year. Marketing Activities: Investment Allocation Breakout Large Companies Emerging Companies Websites Other Speaker Market Access/ 3% PR, Speaker PR, Training Reimbursement Training Media 1% Media 9% 5% 9% Publications Product Pubs 21% Strategy 12% Product Product Strategy 70% includes branding, Strategy product campaigning 72% & strategic marketing planning. N=11 N=4 Copyright © Best Practices®, LLC 7 BEST PRACTICES, ® LLC
  • 8. Market Intel Activities Most Often Involve GSM Leadership Market Intelligence is the area where GSM organizations most frequently take on a lead role, with a large majority leading at all product development phases. At Phase II, 85% of participating GSM organizations take the lead for Marketing Intelligence activities. Role in Market Intelligence Activities by Development Phase Lead Support None 77% 15% 8% Market Pre-Clinical Intelligence Activities Phase I 77% 8% 15% Activities included in Phase II 85% 8% 8% survey definition: Pricing, Health Phase III 79% 14% 7% Economics, Market Access, Launch 71% 21% 7% Market Research, Forecasting, & Post-Launch 71% 14% 14% Business/ Competitive Intelligence N=14 % Responses Q. For Market Intelligence activities, please indicate the type of role that Oncology Global Strategic Marketing plays in at each development phase. Copyright © Best Practices®, LLC 8 BEST PRACTICES, ® LLC
  • 9. Additional Activities Led or Supported by Oncology-GSM Benchmarked GSM-Organizations lead or support a variety of additional activities not included in the survey. These range from developing e-media to developing payer information around personalized healthcare. Additional GSM Activity Involvement by Phase Pre- Post- Phase I: Phase II: Phase III: Launch: Clinical: Launch Personalized Healthcare / x Payer evidence Forecasting x x x x M&S cost planning x x x x Training x x Educational programs x E-media x Q. In the past fiscal year, what other important activities (not listed in survey) were led or supported by Oncology GSM? (List additional GSM activities conducted at each phase.) Copyright © Best Practices®, LLC 9 BEST PRACTICES, ® LLC
  • 10. Voices from the Field: Key Success Factors in Oncology-GSM Verbatim Responses from Benchmark Partners “Close co-operation between global, regions and countries – ‘common language’ & Global Issues common targets.” “Ensure development of global brand and quick execution globally.” “Proper leadership in building the oncology organization (including other functional areas, such as Medical Affairs).” Collaboration “Develop a strong global Medical Affairs organization.” “Seek appropriate Commercial input on clinical development plans.” “Gain KOL support earlier than launch phase-- especially if new technology is involved.” New Technology, “Understanding the impact of biomarkers and diagnostic capabilities.” Markets, “Personalized medicine, cost of therapy.” Stakeholders “Define the right target audience, including new stakeholders (e.g., on biomarkers).” “Patient segmentation, efficacy and safety requirements, personalized care, payer & Market market access requirements.” Access “Market access is becoming more and more critical.” Other “Segment the market so positioning is performed for all market segments.” Success “Accelerate uptake through EAP at launch.” Factors “Strategic planning is vital.” Q. What issues will be critical for Oncology Global Strategic Marketing to address in the next 24-36 months to ensure the success of products your organization hopes to bring to market? Copyright © Best Practices®, LLC 10 BEST PRACTICES, ® LLC
  • 11. About Best Practices, LLC Best Practices, LLC is a research and consulting firm that conducts work based on the simple yet profound principle that organizations can chart a course to superior economic performance by studying the best business practices, operating tactics and winning strategies of world-class companies. Best Practices, LLC 6350 Quadrangle Drive, Suite 200, Chapel Hill, NC 27517 919-403-0251 bestpractices@best-in-class.com www.best-in-class.com Copyright © Best Practices®, LLC 11 BEST PRACTICES,® LLC