This presentation describes the Basque Strategies for industrial diversification in knowledge intensive sectors, namely Bio, Nano and Energy sectors (BioBasque, NanoBasque and EnergiBasque)

1. SMART SPECIALISATION STRATEGIES IN
THE BASQUE COUNTRY
Cristina Oyón
Strategic Initiatives
SPRI

2. Basque strategies for industrial diversification in
knowledge intensive sectors…
Knowledge
generation
Business
development
Sector
dynamisation

3. …knowledge generation in the Basque innovation System

4. …sustained public inventement in knowledge
generation
Ppto. Subvención
PROYECTO Subv. 2009 Subv. 2010 Subv. 2011 Subv. 2012 Subv. 2013
Aceptado Total
GENEDIS 3 1.428.324 1.394.358 1.394.358
LINCE 853.609 797.987 407.891 390.096
ENERGIGUNE'09 5.999.164 5.568.374 2.738.755 1.363.552 1.466.067
ENERGIGUNE'10 4.535.447 4.234.072 1.373.868 1.433.601 1.426.603
ENERGIGUNE'11 1.921.659 1.830.366 144.911 783.928 901.527
PROGRAMA CICs 6.724.590 6.724.590 1.015.127 1.972.463 1.000.500 2.736.500
21.462.793 20.549.747 5.556.131 5.099.979 4.045.079 4.947.031 901.527

5. …sustained public inventement in knowledge
generation
Ppto. Subvención
PROYECTO Subv. 2009 Subv. 2010 Subv. 2011 Subv. 2012
Aceptado Total
MICAS 1.651.080 1.495.380 1.495.380
MICAS-CIC 477.352 454.513 191.168 263.345
MIVDIRA 2.058.699 1.986.533 737.983 605.251 643.299
MIBIO2 4.343.582 4.192.184 1.784.335 1.109.151 1.298.698
PREDETECT 165.835 157.401 157.401
Programa CICs 1.970.751 1.970.751 397.854 554.487 187.633 830.776
10.667.299 10.256.762 2.822.385 3.207.418 2.097.484 2.129.474
Ppto. Subvención
PROYECTO Subv. 2009 Subv. 2010 Subv. 2011 Subv. 2012 Subv. 2013
Aceptado Total
i-NANOGUNE 3.679.916 3.410.876 1.591.696 1.819.180
i-NANOGUNE II 4.779.529 4.615.276 1.528.800 1.498.606 1.587.870
NANOIKER 5.871.699 5.621.876 2.065.804 1.654.834 1.901.238
NANOIKER'11 2.352.372 2.257.955 338.209 939.136 980.610
Programa CICs 8.762.125 8.762.125 1.901.250 2.500.875 1.780.000 2.580.000
25.445.641 24.668.108 5.021.746 7.884.465 5.360.913 5.420.374 980.610

6. …sustained public inventement in knowledge
generation
Ppto. Subvención
PROYECTO Subv. 2009 Subv. 2010 Subv. 2011 Subv. 2012 Subv. 2013
Aceptado Total
BIOMAGUNE'07 343.123 340.434 340.434
BIOMAGUNE'08 1.881.066 1.751.332 1.000.382 750.950
BIOMAGUNE'09 7.081.634 6.897.890 4.284.453 1.207.305 1.406.132
BIOMAGUNE'10 5.980.842 5.610.139 3.046.771 1.328.571 1.234.797
BIOMAGUNE'11 3.371.872 3.077.505 289.626 1.420.714 1.367.165
Programa CICs 11.661.657 11.661.657 2.188.750 1.775.633 4.500.000 3.197.274
30.320.194 29.338.957 7.814.019 6.780.659 7.524.329 5.852.785 1.367.165
Ppto. Subvención
PROYECTO Subv. 2009 Subv. 2010 Subv. 2011 Subv. 2012 Subv. 2013
Aceptado Total
BIOGUNE'07 36.000 36.000 36.000
BIOGUNE'08 3.637.674 3.454.616 1.667.485 1.787.131
BIOGUNE'09 6.841.903 6.466.442 3.487.961 1.232.218 1.746.263
BIOGUNE'10 5.884.207 5.531.115 2.056.884 1.754.005 1.720.226
BIOGUNE'11 3.618.035 3.340.400 95.070 1.583.521 1.661.809
Programa CICs 10.920.975 10.920.975 2.528.155 2.327.120 3.636.000 2.429.700
30.938.794 29.749.548 7.719.601 7.403.353 7.231.338 5.733.447 1.661.809

7. …business development: impact on sectors
ETORGAI programme: 140 M€ of public investment for the support of
collaborative strategic industrial R&D (2008-2011) have mobilised 560 M€
7

8. …sector dynamization: innovation support system
R&D support
Entrepreneurship
Technology Transfer
Venture capital
Internationalisation
Talent attraction

9. nanoBasque
Strategy
A vision of the future

10. The nanoBasque Strategy
The incorporation of nanosciences, micro and nanotechnologies as an
strategic area of industrial diversification within the Basque science,
technology and innovation policies have been done with a twofold
objective:
 To exploit the large potential for application of these technologies
in practically all the Basque industrial sectors
 To promote the creation of new technology based firms (NTBF)
specifically born to develop their activity with applications based
on these technologies.
10

11. The nanoBasque Strategy
nanoBasque is based on a
new relational model, in
which companies need to
cooperate more closely
with research centers and
universities for reaching a
quantitative and qualitative
step ahead, to compete
globally with new products
and processes of greater
value…
11

12. The nanoBasque Strategy
nanoBASQUE Strategy is structured around:
Lines of action: Strategic areas/ Key concepts:
 Business development  materials
 Knowledge generation  micro- nano- bio convergence
 Sector dynamization  enabling tools and techniques
 environment, health and safety
12

13. Knowledge generation
New relational model is needed to transfer the generated knowledge
 90% of companies active in micro/nano require
the collaboration of scientific and
technological agents for carrying out their
activities
 59 agents- of the 103 collaborators referred by
the companies- are members of the Basque
Science, Technology and Innovation network,
being essential for the area development
 Research Centers and Universities tend to be
the main collaborators of the active firms
*  The difficult access to equipments has been
*
identified as a major barrier to the micro –
* nano activity development
*
*
It is evident the importance of the scientific and technological agents in
supporting the technological development of micro and nanotechnologies
13

14. Knowledge generation
Key strategic area for knowledge generation
Enabling tools and
techniques
 The continued training of our scientific and technological system in
tools and techniques for the characterization, synthesis, analysis,
design, modeling, and manufacturing is key to enable the
introduction of micro and nano in our companies.
 The relevance of instrumentation is behind the strong stimulus
provided by the Basque Government and embodied in the
construction of world class facilities: the microGUNE and
nanoGUNE Cooperative Research Centers, as well as the specific
programs for the development of scientific infrastructures.
14

15. Knowledge generation
Knowledge development strategic areas and agents in nanosciences and nanotechnologies
FIVE STRATEGIC AREAS
Nanomagnetism
Nanostructured materials for
construction
Carbon nanostructures
Polymeric materials
Nanophotonic devices
+ 200 researchers
15

16. Knowledge generation
Knowledge development Strategic areas and Agents in Microtechnologies
Coordinates the research
activity of 70 researchers
Cooperation between different entities
THREE STRATEGIC AREAS
Microsensors
Microfluidics
Micro/Nano engineering
16

17. Business Development: Impact on sectors.
Key strategic areas for business development: Impact on sectors
Materials
 Key factor for the Basque business competitiveness
 The micro and nanotechnology incorporation may allow:
 An increase in the technology intensity
 A diversification into higher value products
We are not starting from scratch:
 Strong capabilities in the Basque scientific and technological agents
 Tractor companies in key sectors able to put the products of the
future on the market.
17

18. Business Development: Impact on sectors.
There are 67 firms involved in micro and/or nano, 19 starts up
Sector Distribution
The horizontal nature
of micro and
nanotechnologies is
reflected in the
identification of
active companies in
more than 15
industrial sectors
The use of these technologies in the steel, automotive
and energy sectors is of special relevance
18

19. Business Development: Impact on sectors. Projects examples
Development of Nanotechnology based products and processes for the
NANO-4-CAR automotive sector
Development of Nanoalloyed special steels, for products of very high
performance. Its nano structural characteristics allow to eliminate intensive
DISAUTO
energy intermediate operations in the manufacturing process.
NANOSEG Development of new nanotechnolgy based products for the energy, food and
automotive sector. New products for nanosafety
ASEGURA
Increase the safety without compromising the vehicle weight and fuel systems,
incorporating innovative polymer for passive and active safety

20. Business Development: New sector generation
Key strategic areas for Business development: new sector generation
Micro-Nano-Bio
Convergence
The convergence of
these areas offers in the
health and quality of life
sector a perfect
opportunity to enhance
the Basque Country
skills and to create
market applications
through joint
knowledge.
20

21. Business Development: New sector generation
There are 67 firms involved in micro and/or nano, 19 start-ups
Sector distribution
The new technology
based firms in micro
and nanotechnology
are concentrated in
the areas of health,
pharmaceuticals and
biotechnology.
21

22. Business Development: New sector generation. Some examples
microINR: Oral Anticoagulation Therapy (OAT) Point of care monitoring
Polymer microspheres for different applications: clinic diagnosis reactives,
particular colloidal models …
Tisular engineering and cellular therapy, devoted to the development of
NANOSEG
products in regenerative and repair medicine
Development and commercialization of new biosensors that can detect
ASEGURA
molecules of interest for the enology, agro food and bio- health sectors.

23. “A vision of the future”
nanoBasque Agency
Amaia Martinez
www.nanobasque.eu
nanobasque@spri.es
23

24. BioBasque, the Basque BioRegion
A new hub for life sciences

25. General context for life sciences in BioBasque
• Commitment with biosciences: a longterm vision and strategy
• Answers to global forces in health and sustainability
• Life sciences as a new avenue for growth (with diversification from
traditional industries)
• A pro-business government
• Proven Regional Innovation System
• Pioneers in clustering
• Integrative approach: translational research
• State-of-the-art facilities and Technology
platforms
• Specialist research and business partners:
efficacious and efficient

26. BioRegion evolution: STI
Main changes since 2002
Increase in scientific and Biokutxa
technological capacities
Reinforced processes of
company creation
(bioincubator) and
acceleration

27. Research community, Science & Technology capacity
Specialist fields, converging technologies
Genomics and genotyping, Chemistry, Biophysics,
gene silencing, proteomics, Pharmacology, etc.
metabolomics, cellular
biology & stem cells, etc. Bioethics
Researchers organised
in “Knowledge Communities”,
Private-public cooperation,
IPR framework &
Biomaterials,
biosurfaces, protection Engineering,
nanobiotechnology electronics, materials,
manufacturing
Nanoscience & technology,
microtechnologies

28. State-of-the-art facilities and technology platforms (I)
• Structural Biology: stepwise build-up from local to
global structure with increasing resolution and complexity
NMR
Integral
Electronic
solutions
Microscopy
X-ray

29. State-of-the-art facilities and technology platforms (I)
Drug discovery and development by NMR
Initial HITS
LEADS
Drug Target
Affinity
mM µM CANDIDATES
NMR Screening Affinity
µM nM
• Highly sensitive
NMR Screening LENS Process & Drug
• NMR-tailored CombiChem Drug-Like Properties Candidate
Library of
Building Blocks • NMR-guided
Drug Design Medicinal
• Specialised Chemistry
Ligand Library from
• in vitro / in vivo
Combinatorial
testing of drug-like
Chemistry
ligands
• ADME profiling
LENS = Lead structure Evolution by NMR & Simulation

30. State-of-the-art facilities and technology platforms (II)
• Molecular (preclinical) Imaging: singular unit to study
living organisms in a non-invasive manner, and to
improve drug discovery & development
• Computerized tomography, CT
• Magnetic Resonance Imaging, MRI
• Cyclotron (11,7 Tesla)
• Radiochemistry lab
• Radiopharmaceutical lab
• Nuclear Imaging: PET, SPECT
• fMRI, MRS
• Animal facility

31. The Health System
Biomedical Research
Institutes
BIOEF aim: promotion of innovation and
research in the Basque Public Health
System.
Nodal biobank within
the health system.
7 main hospitals (4 university), Experimental Units, Databases and
registers: mental health, cancer; longitudinal studies, health survey,
Clinical Trials Network (1 regional Management Office)

32. Business evolution in the BioRegion
Business scenario in 2001
Not a sector, just companies

33. Business scenario in 2010
A biocluster
A new company
every 3 months
Nucleus: does not include
telemedicine companies, etc.

34. Some products

35. BioBasque Agency
Maria Aguirre
www.biobasque.com
biobasque@spri.es

36. …thanks
cristina@spri.es