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Geneticists group




Cloning
WHAT EXACTLY IS CLONING?




 Cloning is the creation of an organism that is an exact genetic
copy of another. This means that every single bit of DNA is the
                                        same between the two!
The types of cloning




Hybrid cloning   Therapeutic cloning   Reproductive cloning
HOW IS CLONING DONE?


  How does one go about making an exact genetic copy of an organism? There are a
couple of ways to do this: artificial embryo twinning and somatic cell nuclear transfer.




                                     How do these processes differ?
Artificial Embryo Twinning




 Artificial embryo twinning is the relatively low-tech
      version of cloning. As the name suggests, this
   technology mimics the natural process of creating
                     identical twins.




                                        Artificial Process Video
Somatic Cell Nuclear Transfer



  Somatic cell nuclear transfer, (SCNT) uses a
  different approach than artificial embryo twinning,
  but it produces the same result: an exact clone, or
  genetic copy, of an individual. This was the method
  used to create Dolly the Sheep.




                                      Somatic Process Video
AdVantages and
Disadvantages
History of cloning in
mammals


Dolly the sheep   Herd of mice   Cat (CC)
DEGREE OF AGING




One risk of cloning is that the cells of the clone can aging faster
                                           than the normal persons
IMPORTANCE OF RESEARCH
                    INTO CLONING



It is important that we continue to investigate this area to improve
                                 the technique and reduce the risks
No current clinical treatments

       Few successes in animal models

Difficulty in obtaining pure cultures in the dish

Questions regarding functional differentiation

      Difficult to establish and maintain
                                                    Current and
        Problem of immune rejection                 potential
   Potential for tumor formation and tissue         embryonic
                   destruction
                                                    stem cell
              Genomic instability                   problems:
             Ethically contentious
Current
                      Cancers
Clinical Uses
of Adult             leukemias
Stem Cells      Autoimmune diseases
                      Anemias
                 Bone deformities
                       Stroke
                    Parkinson’s
                        Skin
This is a very relevant question.

There is indeed a relationship between the clone and original
one. Since we are not facing a real situation, it is not urgent to
   create a new concept that would fit this "relationship".
Bibliography




http://www.scientificamerican.com/search/?q=human+cloning

www.humancloning.org

http://news.bbc.co.uk/2/shared/spl/hi/pop_ups/03/health_stem_cell_guide/html/5.stm

http://www.liebertonline.com/doi/abs/10.1089/153623002753632057

Google and Others
By



Ana Isabel Silva
António Pedro
Cláudia Costa
Filipa Rodrigues
Marta Fernández    11ºA
Fim da apresentação. Clique para sair.
Reproductive Cloning|Adult dna cloning



   Reproductive cloning is a technology used
     to generate an animal that has the same
       nuclear DNA as another currently or
           previously existing animal.

  Human cloning also falls into this category.


               e.g. identical twins
Therapeutic Cloning




   The purpose of therapeutic cloning is to
    extract the stem cells from the embryos.

 Stem cells can be used to treat heart disease,
     Alzheimer's, cancer, and various other
                    diseases.

       e.g. heart or even just a few cells
Hybrid cloning


   A clone has been made ​from this
               technique.

  It was achieved using a cell from a
       man's leg and a cow's egg.

  It is called hybrid because it uses 2
          different power sources.
Advantages
    1/Potential benefits to modern medicine

          2/Helping infertile couples

         3/Reverse the aging process

        4/Protecting Endangered Species

             5/ Improving food supply
Disadvantages

       1/The Element of Uncertainty

           2/Inheriting diseases

        3/The Potential for Abuse
Dolly the sheep




                     She was born on 5 july 1996.

      She was cloned by Ian Wilmut and keith campbell in Scotland

                   Was the first mammal to be cloned

                 Died from a progressive lung disease
Herd of mice




  The first cloned mammals was a mouse (named "Masha") in 1986, in the Soviet
                                   Union.

                    The cloning was done from an embryo cell.

  The first mouse from adult cells, Cumulin, was born in 1997 at the University of
                                 Hawai'i at Mānoa.

                          Over a dozen clones as of 2002.
Cat (CC)




                 Was born in December 2001,
    scientists at Texas A&M University created the first
                  cloned cat, CC (CopyCat).

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Human cloning

  • 2. WHAT EXACTLY IS CLONING? Cloning is the creation of an organism that is an exact genetic copy of another. This means that every single bit of DNA is the same between the two!
  • 3. The types of cloning Hybrid cloning Therapeutic cloning Reproductive cloning
  • 4. HOW IS CLONING DONE? How does one go about making an exact genetic copy of an organism? There are a couple of ways to do this: artificial embryo twinning and somatic cell nuclear transfer. How do these processes differ?
  • 5. Artificial Embryo Twinning Artificial embryo twinning is the relatively low-tech version of cloning. As the name suggests, this technology mimics the natural process of creating identical twins. Artificial Process Video
  • 6. Somatic Cell Nuclear Transfer Somatic cell nuclear transfer, (SCNT) uses a different approach than artificial embryo twinning, but it produces the same result: an exact clone, or genetic copy, of an individual. This was the method used to create Dolly the Sheep. Somatic Process Video
  • 8. History of cloning in mammals Dolly the sheep Herd of mice Cat (CC)
  • 9. DEGREE OF AGING One risk of cloning is that the cells of the clone can aging faster than the normal persons
  • 10. IMPORTANCE OF RESEARCH INTO CLONING It is important that we continue to investigate this area to improve the technique and reduce the risks
  • 11. No current clinical treatments Few successes in animal models Difficulty in obtaining pure cultures in the dish Questions regarding functional differentiation Difficult to establish and maintain Current and Problem of immune rejection potential Potential for tumor formation and tissue embryonic destruction stem cell Genomic instability problems: Ethically contentious
  • 12. Current Cancers Clinical Uses of Adult leukemias Stem Cells Autoimmune diseases Anemias Bone deformities Stroke Parkinson’s Skin
  • 13. This is a very relevant question. There is indeed a relationship between the clone and original one. Since we are not facing a real situation, it is not urgent to create a new concept that would fit this "relationship".
  • 15. By Ana Isabel Silva António Pedro Cláudia Costa Filipa Rodrigues Marta Fernández 11ºA
  • 16. Fim da apresentação. Clique para sair.
  • 17. Reproductive Cloning|Adult dna cloning Reproductive cloning is a technology used to generate an animal that has the same nuclear DNA as another currently or previously existing animal. Human cloning also falls into this category. e.g. identical twins
  • 18. Therapeutic Cloning The purpose of therapeutic cloning is to extract the stem cells from the embryos. Stem cells can be used to treat heart disease, Alzheimer's, cancer, and various other diseases. e.g. heart or even just a few cells
  • 19. Hybrid cloning A clone has been made ​from this technique. It was achieved using a cell from a man's leg and a cow's egg. It is called hybrid because it uses 2 different power sources.
  • 20. Advantages 1/Potential benefits to modern medicine 2/Helping infertile couples 3/Reverse the aging process 4/Protecting Endangered Species 5/ Improving food supply
  • 21. Disadvantages 1/The Element of Uncertainty 2/Inheriting diseases 3/The Potential for Abuse
  • 22. Dolly the sheep She was born on 5 july 1996. She was cloned by Ian Wilmut and keith campbell in Scotland Was the first mammal to be cloned Died from a progressive lung disease
  • 23. Herd of mice The first cloned mammals was a mouse (named "Masha") in 1986, in the Soviet Union. The cloning was done from an embryo cell. The first mouse from adult cells, Cumulin, was born in 1997 at the University of Hawai'i at Mānoa. Over a dozen clones as of 2002.
  • 24. Cat (CC) Was born in December 2001, scientists at Texas A&M University created the first cloned cat, CC (CopyCat).

Notes de l'éditeur

  1. Esta apresentação demonstra as novas capacidades do PowerPoint, sendo melhor visualizada na Apresentação de Diapositivos. Estes diapositivos foram concebidos para lhe dar excelentes ideias para as apresentações que criará no PowerPoint 2010!Para obter mais modelos de exemplo, clique no separador Ficheiro e, no separador Novo, clique em Modelos de Exemplo.