For an Executive Summary of this report please contact ediz.ibrahim@visiongain.com (+44 (0)20 7549 9976) or refer to our website https://www.visiongain.com/Report/1306/Allergic-Rhinitis-Drugs-Market-Forecast-2014-2024
2. Contents
1. Report Overview
1. Report Overview
1.1 Global Allergic Rhinitis Drugs Market Overview
1.2 Global Allergic Rhinitis Drugs Market Segmentation
1.3 Why You Should Read This Report
1.4 How This Report Delivers
1.5 Key Questions Answered by This Analytical Report
1.6 Who is This Report For?
1.7 Methodology
1.8 Frequently Asked Questions (FAQ)
1.9 Associated Visiongain Reports
1.10 About Visiongain
2. Introduction to Allergic Rhinitis
2. Introduction to Allergic Rhinitis
2.1 The Pharmaceutical Industry: a Very Brief Overview
2.2 A Brief Overview of Allergy
2.3 Allergic Rhinitis
2.3.1 The Global Prevalence of Allergic Rhinitis
2.3.2 Pathophysiology of Allergic Rhinitis: IgEs and Mast Cells
2.3.3 Symptoms of Allergic Rhinitis
2.3.4 Classification of Allergic Rhinitis
2.3.4.1 Non-Allergic Rhinitis and Mixed Rhinitis
2.3.5 Seasonal Allergic Rhinitis (Hay Fever)
2.3.6 Perennial Allergic Rhinitis
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3. Contents
2.3.7 Diagnosis of Allergic Rhinitis
2.4 Treatment of Allergic Rhinitis
2.4.1 Antihistamines
2.4.1.1 First-Generation Antihistamines
2.4.1.2 Second- and Third-Generation Antihistamines
2.4.2 Corticosteroids
2.4.2.1 First-, Second- and Third-Generation Intranasal Corticosteroids
2.4.2.2 Combination Drug Products
2.4.3 Leukotriene Receptor Antagonists
2.4.4 Cromolyn (cromoglicic acid)
2.4.5 Decongestants
2.4.6 Saline Nasal Sprays
2.4.7 Immunotherapy and Vaccines
2.5 Phases of Clinical Trials
2.6 Scope of this Report
2.7 Currency Exchange Rates in This Report
3. Allergic Rhinitis Drugs: World Market 2014-2024
3. Allergic Rhinitis Drugs: World Market 2014-2024
3.1 The World Allergic Rhinitis Drugs Market in 2013
3.1.1 Leading Allergic Rhinitis Drugs
3.1.2 Leading Companies in the Allergic Rhinitis Drugs Market
3.2 World Allergic Rhinitis Drugs Market: Sales Forecast 2014-2024
3.3 Oral Antihistamines Lead the World Allergic Rhinitis Drugs Market
3.4 How Will Segmental Market Shares Change to 2024?
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4. Contents
3.5 World Allergic Rhinitis Drugs Market: Drivers and Restraints 2014-2024
4. Leading National Markets 2014-2024
4. Leading National Allergic Rhinitis Drugs Markets 2014-2024
4.1 Geographical Breakdown of the World Allergic Rhinitis Drugs Market
4.2 World Allergic Rhinitis Drugs Market: National Markets Forecast 2014-2024
4.2.1 How Will National Market Shares Change to 2024?
4.3 The US Allergic Rhinitis Drugs Market 2014-2024
4.3.1 US Allergic Rhinitis Drugs Market Forecast 2014-2024
4.3.2 US Allergic Rhinitis Drugs Market: Trends and Developments
4.3.2.1 Rx-to-OTC Switching of Intranasal Corticosteroids
4.3.2.2 Affordable Care Act: Expanding Medicare Coverage
4.4 Chinese Allergic Rhinitis Drugs Market 2014-2024
4.4.1 Chinese Allergic Rhinitis Drugs Market Forecast 2014-2024
4.4.2 Chinese Allergic Rhinitis Drugs Market: Trends and Developments
4.4.2.1 Air Pollution Associated With Increasing Prevalence
4.4.2.2 Expansion of Healthcare Coverage and Reimbursement
4.5 Japanese Allergic Rhinitis Drugs Market 2014-2024
4.5.1 Japanese Allergic Rhinitis Drugs Market Forecast 2014-2024
4.5.2 Japanese Allergic Rhinitis Drugs Market: Trends and Developments
4.5.2.1 Cedar Reforestation and the Hay Fever Epidemic
4.5.2.2 Generic Penetration to Reach 60% by 2018?
4.5.2.3 Genetically Modified Rice as Immunotherapy
4.6 EU5 Allergic Rhinitis Drugs Market 2014-2024
4.6.1 German Allergic Rhinitis Drugs Market Forecast 2014-2024
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5. Contents
4.6.2 French Allergic Rhinitis Drugs Market Forecast 2014-2024
4.6.3 UK Allergic Rhinitis Drugs Market Forecast 2014-2024
4.6.4 Italian Allergic Rhinitis Drugs Market Forecast 2014-2024
4.6.5 Spanish Allergic Rhinitis Drugs Market Forecast 2014-2024
4.6.6 EU5 Allergic Rhinitis Drugs Market: Trends and Developments
4.6.6.1 Germany: Reform of AMNOG Pharmaceutical Rebate Law
4.6.6.2 France: Social Security Finance Bill 2014
4.6.6.3 UK: Increasing Burden of Allergy
4.6.6.4 Italy: Austerity Measures Limiting Growth
4.6.6.5 Spain: The Start of Recovery in the Spanish Economy
4.7 Russian Allergic Rhinitis Drugs Market 2014-2024
4.7.1 Russian Allergic Rhinitis Drugs Market Forecast 2014-2024
4.7.2 Russian Allergic Rhinitis Drugs Market: Trends and Developments
4.7.2.1 Pharma2020 and the Russian Pharmaceutical Industry
4.8 Indian Allergic Rhinitis Drugs Market 2014-2024
4.8.1 Indian Allergic Rhinitis Drugs Market Forecast 2014-2024
4.8.2 Indian Allergic Rhinitis Drugs Market: Trends and Developments
4.8.2.1 Drug Prices Control Order 2013
4.8.2.2 Expansion of Healthcare Provision
4.9 Brazilian Allergic Rhinitis Drugs Market 2014-2024
4.9.1 Brazilian Allergic Rhinitis Drugs Market Forecast 2014-2024
4.9.2 Brazilian Allergic Rhinitis Drugs Market: Trends and Developments
4.9.2.1 Increasing Access to Medicines
4.10 Mexican Allergic Rhinitis Drugs Market 2014-2024
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15. Contents
11.2 Strengths
11.2.1 High Unmet Clinical Need
11.2.2 Established Role of Allergic Rhinitis Drugs in Treatment
11.2.3 High Profile Disease Encouraging Improving Healthcare Provision
11.2.4 Increasing Consumer Demand
11.3 Weaknesses
11.3.1 Increasing Generic Penetration
11.3.2 Patient Dissatisfaction with Intranasal Corticosteroids
11.3.3 Limited Allergic Rhinitis Drugs Pipeline
11.4 Opportunities
11.4.1 The Rise of Immunotherapy
11.4.2 Higher Growth in Emerging Markets
11.4.3 Combination Drug Products
11.4.4 Rx-to-OTC Switching
11.5 Threats
11.5.1 Patent Expiry
11.5.2 Cost-Containment
11.5.3 Rising API and Manufacturing Costs
11.6 Porter’s Five Forces Analysis of the Allergic Rhinitis Drugs Market
11.6.1 Rivalry Among Competitors [High]
11.6.2 Threat of New Entrants [Low]
11.6.3 Power of Suppliers [Low]
11.6.4 Power of Buyers [Medium]
11.6.5 Threat of Substitutes [Low]
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16. Contents
12. Research Interviews
12. Research Interviews
12.1 Interview with Maureen Jenkins, Director of Clinical Services for Allergy UK, Sidcup, Kent,
UK
12.1.1 Allergic Rhinitis in the UK
12.1.2 Allergic Rhinitis Treatments
12.1.3 Opportunities for Manufacturers
12.2 Interview with Kimihiro Okubo, Chairman and Professor, Department of Otolaryngology,
Nippon Medical School, Tokyo, Japan
12.2.1 Allergic Rhinitis in Japan
12.3 Interview with Jonathan Bernstein, Chairman and Professor, Department of Internal
Medicine, University of Cincinnati, Ohio, US
12.3.1 Allergic Rhinitis in the US
12.3.2 Nasacort AQ and OTC Nasal Sprays
12.3.3 Dymista and Combination Therapies
12.3.4 Trends and Developments in Allergic Rhinitis
12.4 Interview with Tonya Winders, President and CEO, Allergy & Asthma Network Mothers of
Asthmatics, Virginia, US
12.4.1 Allergic Rhinitis in the US
12.4.2 Allergic Rhinitis Treatments
12.4.3 US Healthcare Reform and Intranasal Drugs
12.5 Interview with Allergy Medical UK, Weybridge, UK
12.5.1 Allergic Rhinitis Treatments
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17. Contents
13. Conclusions
13. Conclusions
13.1 Allergic Rhinitis Drugs: A Mature Market
13.2 The World Allergic Rhinitis Market in 2013
13.2.1 Current Leading Allergic Rhinitis Segments
13.2.2 Leading Allergic Rhinitis Products
13.2.3 Leading Allergic Rhinitis Drugs Companies
13.2.4 Leading National Markets
13.3 World Allergic Rhinitis Drugs Market Forecast 2014-2024
13.4 Allergic Rhinitis Late-Stage Pipeline 2014
13.5 The Future of the Allergic Rhinitis Drugs Market?
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18. Allergic Rhinitis Drugs Market Forecast 2014-2024:
Future Prospects for Companies in Antihistamines,
Corticosteroids, Immunotherapy & Vaccines
ISAAC epidemiological study of allergic rhinitis, Argentina, Brazil and Mexico had allergic rhinitis
prevalences in 13-14 year olds (around 2002-2003) of 16.9%, 15.8% and 7.1% respectively.
Another epidemiological study called Allergies in Latin America was conducted in February-April
2008 and reported that 67% of allergic rhinitis sufferers were using medication for their condition.
24% reported using a prescription nasal spray in the past four weeks while 42% also reported
using OTC medication. Prescription nasal spray use was higher in Mexico (26%) and Argentina
(21%) than in Brazil (19%). The opposite pattern was seen in terms of patients not being treated at
all, with 43% not being treated in Brazil compared to 34% in Argentina and 28% in Mexico. Other
countries with higher use of prescription nasal sprays were Venezuela (49%), Colombia (33%) and
Chile (27%). The use of prescription nasal sprays was influenced by effectiveness, medical
opinion, patient choice, side-effects and cost. These findings suggest that there is further room for
expansion in the Brazilian and Mexican markets.
4.9.1 Brazilian Allergic Rhinitis Drugs Market Forecast 2014-2024
Table 4.15 and Figure 4.16 show visiongain’s forecast for the Brazilian allergic rhinitis drugs
market over 2013-2024.
Visiongain estimates that in 2013, the Brazilian allergic rhinitis drugs market reached $202m,
representing 1.8% of the world market. In 2014 the Brazilian market will increase to $227m, up
12.3% on 2013. High growth in this market is expected as the demand for allergic rhinitis drugs
increases. Expansion of healthcare provision in Brazil and strong economic growth will drive
demand. Visiongain predicts that the Brazilian market will grow with a CAGR of 12.4% over 2013-
2018 to reach $363m in 2018. The Brazilian market will grow at a CAGR of 11.7% over 2018-2024
to reach $705m in 2024, representing an overall CAGR of 12.0% over 2013-2024.
Table 4.15 Brazilian Allergic Rhinitis Drugs Market Forecast: Revenues ($m), AGR
(%), CAGR (%), 2013-2024
2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Brazil ($m) 202 227 255 289 323 363 409 466 526 589 655 705
Annual Growth Rate (%) 12.3 12.1 13.3 12.0 12.2 12.8 13.9 12.9 11.9 11.1 7.7
CAGR (%, 2013-2018
and 2018-2024) 12.4 11.7
CAGR (%, 2013-2024) 12.0
Source: visiongain 2014
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19. Allergic Rhinitis Drugs Market Forecast 2014-2024:
Future Prospects for Companies in Antihistamines,
Corticosteroids, Immunotherapy & Vaccines
Table 6.18 and Figure 6.19 show visiongain’s estimates of Nasacort sales by volume over 2013-
2024.
Table 6.18 Sanofi: Nasacort Sales Forecast by Volume: Sprays (million), AGR (%),
CAGR (%), 2013-2024
2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Nasacort (million
sprays) 2.1 6.3 8.9 11.5 13.8 12.7 12.1 11.7 11.6 12.1 12.6 13.1
Annual Growth Rate (%) 206.6 40.0 30.0 20.0 -8.0 -5.0 -3.0 -1.0 4.0 4.0 4.0
CAGR (%, 2013-2018
and 2018-2024) 43.9 0.4
CAGR (%, 2013-2024) 18.3
Source: visiongain 2014
Figure 6.19 Sanofi: Nasacort Sales Forecast by Volume: Sprays (million), AGR (%),
2013-2024
16.0
14.0
12.0
10.0
8.0
6.0
4.0
2.0
0.0
2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Volume (million sprays)
Source: visiongain 2014
6.14 QNasl (beclometasone, Teva)
250.0
200.0
150.0
100.0
50.0
0.0
-50.0
AGR (%)
Year
Volume (million sprays)
AGR (%)
QNasl (beclometasone dipropionate, Teva) is a new formulation of beclometasone approved by
the FDA in 2012. It is described as a “dry” nasal aerosol with a HFA propellant, as opposed to
aqueous nasal sprays, and is the first such dry spray to reach the US market for allergic rhinitis.
There is an unmet need for these types of spray due to the inconvenience of aqueous sprays: in
2010 the National Allergy Survey Assessing Limitations (NASAL) survey found that 1 in 5 patients
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20. Allergic Rhinitis Drugs Market Forecast 2014-2024:
Future Prospects for Companies in Antihistamines,
Corticosteroids, Immunotherapy & Vaccines
7.8.1 Patanase: Sales Forecast 2014-2024
Visiongain estimates that in 2013, Patanase revenues reached $41m, little changed from 2012
revenues of $40m. Sales will grow 3.3% to $43m in 2014. Visiongain believes that growth will be
slow during the forecast period, based on historical sales trends, and will reflect increasing demand
for allergic rhinitis drugs offset by the fact that many alternatives are available, including generic
azelastine. Visiongain predicts that Patanase revenues will grow with a CAGR of 3.9% over 2013-
2018 to reach $50m in 2018. Due to patent expiration in 2023 and falling revenues thereafter,
Patanase revenues will decline at a CAGR of -4.4% over 2018-2024 to reach $38m in 2024,
representing an overall CAGR of -0.7% over 2013-2024.
Table 7.5 and Figure 7.7 show visiongain’s estimates of Patanase revenues over 2013-2024.
Table 7.5 Novartis: Patanase Revenue ($m), AGR (%), CAGR (%), 2013-2024
2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
Patanase ($m) 41 43 44 46 48 50 52 55 57 60 63 38
Annual Growth Rate (%) 3.3 3.7 4.0 4.2 4.4 4.6 4.8 5.0 5.1 5.1 -40.0
CAGR (%, 2013-2018
and 2018-2024) 3.9 -4.4
CAGR (%, 2013-2024) -0.7
Source: visiongain 2014
Figure 7.7 Novartis: Patanase Revenue ($m), AGR (%), 2013-2024
10.0
5.0
0.0
-5.0
-10.0
-15.0
-20.0
-25.0
-30.0
-35.0
-40.0
-45.0
70
60
50
40
30
20
10
0
2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024
AGR (%)
Sales ($m)
Year Sales ($m) AGR (%)
Source: visiongain 2014
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21. Allergic Rhinitis Drugs Market Forecast 2014-2024:
Future Prospects for Companies in Antihistamines,
Corticosteroids, Immunotherapy & Vaccines
Astepro 0.15%. They do work. In terms of compliance one spray versus two has advantages.
Currently Dymista has a unique market space.
12.3.4 Trends and Developments in Allergic Rhinitis
visiongain: Are there any other trends or developments in the intranasal allergic rhinitis drugs
market?
Jonathan Bernstein: QNasl, the HFA [hydrofluoroalkane] aerosol, has a new mode of delivery. In
terms of novel compounds there are things in early stages of development that are being looked at
but they haven’t generated data in significant patient populations as of yet. Other novel agents
include intranasal CO2 and intranasal capsaicin which is over the counter and has effects on
reducing congestion. For allergic rhinitis, sublingual immunotherapies have been looked at. There
aren’t many novel nasal spray treatments under development at the moment.
12.4 Interview with Tonya Winders, President and CEO, Allergy &
Asthma Network Mothers of Asthmatics, Virginia, US
In March 2014 visiongain interviewed Tonya Winders, President and CEO of the Allergy and
Asthma Network Mothers of Asthmatics (AANMA). AANMA is the leading nonprofit family health
organisation in the US focusing on asthma, allergies and related conditions. We appreciate Tonya
Winders’ time and opinions.
12.4.1 Allergic Rhinitis in the US
visiongain: Can you tell me a little bit about the work that AANMA is doing in the area of allergic
rhinitis?
Tonya Winders: Allergy & Asthma Network Mothers of Asthmatics was founded in 1985 to "end
the needless death and suffering due to asthma, allergies and related conditions through outreach,
education and advocacy." The network is comprised of patients, caregivers and healthcare
professionals dedicated to this mission. We provide training and educational materials for allergic
rhinitis to millions of patients and caregivers each year.
Many people believe allergic rhinitis is just “hay fever” or a mild nuisance to sufferers. In reality, it
has a dramatic impact on a person’s quality of life including missed days at work and school or
“presenteeism” – showing up but not being as productive as normal. The high direct and indirect
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