VisualSonics Inc., a leader in real time, in vivo, high-resolution micro-imaging systems and a wholly-owned subsidiary of SonoSite Inc., announced today that its VevoStrain™ technology has been featured on the cover of the April 15, 2011 issue of Circulation Research, Journal of the American Heart Association.

1. VisualSonics VevoStrain Technology Provides Earlier
Access To Left Ventricular Dysfunctions
Posted April 14th, 2011 in In the News
A new dimension of diagnostic information:
Strain analysis feature of Vevo® 2100 high-frequency ultrasound system enables highly sensitive
and rapid measurement of global (whole heart) and regional (specific heart areas) cardiac
function.
TORONTO, Canada – April 14, 2011 – VisualSonics
Inc., a leader in real time, in vivo, high-resolution micro-
imaging systems and a wholly-owned subsidiary of
SonoSite Inc., announced today that its VevoStrain™
technology has been featured on the cover of the April 15,
2011 issue of Circulation Research, Journal of the
American Heart Association.
VevoStrain provides advanced imaging and quantification
capabilities to study sensitive movements in the heart
muscles – specifically the myocardium. The VevoStrain technology augments high-resolution
imaging capabilities of high-frequency ultrasound with highly sensitive measurements of subtle
variations in the myocardium. The VevoStrain software enables tracking of wall motions in the
heart, including the entire heart as well as defined regions within the heart. Measurement
capabilities include quantification of displacement, velocity, strain and strain rate. Researchers1
at Brigham and Women’s Hospital, Harvard Medical School present the utility of VevoStrain
technology as a non invasive, highly sensitive and rapid cardiac phenotyping tool in their
seminal paper on in vivo strain analysis.
Ronglih Liao, MD, Associate Professor of Medicine, Harvard Medical School said, “We believe
that with strain analysis, we now have a very effective and efficient method for non-invasively
detecting early cardiac performance irregularities in mice. While recognizing that this method
requires special expertise and experience to implement, we are very excited about prospects for
applying these analyses in future studies of experimental therapeutics.”
The VevoStrain software is emerging as the new state-of-the-art assessment tool for quantifying
myocardial mechanical function and deformation, replacing Tissue Doppler imaging, which has
been used in the past. Additional features of the software include measurement of cardiac wall
motion abnormalities, dyssynchrony (delayed ventricular activation and contraction) and
myocardial mechanics.
More information on VevoStrain software is available at:
http://www.visualsonics.com/vevostrain

2. About VisualSonics
VisualSonics is the world leader in real time, in vivo, high-resolution micro imaging systems
designed specifically for preclinical research and a wholly-owned subsidiary of SonoSite, Inc.
(Nasdaq:Sono). The Company’s cutting edge technologies allow researchers at the world’s most
prestigious pharmaceutical and biotechnology companies, hospitals and universities to conduct
research in cardiovascular, cancer, neurobiology and developmental biology areas. The micro
imaging technologies support research applications that include genetic research, phenotypic
studies and drug development. VisualSonics micro imaging platforms combine high-resolution,
real time in vivo imaging at reasonable cost with ease-of-use and quantifiable results.
About SonoSite
SonoSite, Inc. (www.sonosite.com) is the innovator and world leader in bedside and point-of-
care ultrasound and an industry leader in ultra high-frequency micro-ultrasound technology and
impedance cardiography equipment. Headquartered near Seattle, the company is represented by
fourteen subsidiaries and a global distribution network in over 100 countries. SonoSite’s small,
lightweight systems are expanding the use of ultrasound across the clinical spectrum by cost-
effectively bringing high-performance ultrasound to the point of patient care.
1
Bauer M, Cheng S, Liao R; Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular
Phenotyping in Mice; CIRCRESAHA/2010/239574-R1