2. Objectives
• By the end of this lecture you should be able
to:
• Classify the major cell wall and protein
synthesis inhibitors
• Understand their mechanism of action.
• Explain resistance mechanisms against these
antimicrobials.
10. Limitations of Penicillins
• Limited effectiveness against many gram
negative rods
• Hydrolysis by gastric acid
• Inactivation by beta- lactamases
• Hypersensitivity reactions