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Inhibitors of Cell wall and Protein
Synthesis
BDS Semester III
Objectives
• By the end of this lecture you should be able
to:
• Classify the major cell wall and protein
synthesis inhibitors
• Understand their mechanism of action.
• Explain resistance mechanisms against these
antimicrobials.
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Carbapenems
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Limitations of Penicillins
• Limited effectiveness against many gram
negative rods
• Hydrolysis by gastric acid
• Inactivation by beta- lactamases
• Hypersensitivity reactions
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Carbapenems
•Monobactam
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
1. Aminoglycosides
2. Tetracyclins
Inhibition of Protein Syntesis
1. Chloramphenicol
2. Erythromycin
3. Clindamycin
4. Linezolid
5. Streptogramins
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15
Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15

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Inhibitors of Cell wall and protein synthesis in bacteria BDS Sem III 20-2-15